{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:58:29Z","timestamp":1790125109349,"version":"4.0.1"},"reference-count":13,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Among numerous other immune-mediated diseases, glomerulonephritis has also been suspected to be an extrahepatic manifestation of HEV infection. In this prospective study, we tested 108 patients with glomerulonephritis and 108 age- and sex-matched healthy controls at the University Hospital Hamburg Eppendorf, Hamburg, Germany, for anti-HEV IgG (Wantai test) as a marker for previous HEV exposure. A total of 24 patients (22%) tested positive for anti-HEV IgG. Males tended to be more frequently anti-HEV IgG positive (29%) in comparison to females (16%). However, this does not reach statistical significance (p = 0.07). Anti-HEV IgG positive patients were older in comparison to negative patients (mean 53 vs. 45 years, p = 0.05). The kidney function seems to be slightly decreased in anti-HEV IgG positive patients in comparison to and anti-HEV IgG negative patients basing on creatinine (p = 0.04) and glomerular filtration rate (GFR) (p = 0.05). Slightly higher values of bilirubin could be found in IgG positive patients (p = 0.04). Anti-HEV-IgG seropositivity rate (22%) in glomerulonephritis patients, did not differ significantly in comparison to an age- and sex-matched control cohort of healthy blood donors (31\/108 positive, 29%). A total of 2\/2 patients with membranoproliferative glomerulonephritis (MPGN) tested anti-HEV IgG positive (p = 0.002 in comparison to glomerulonephritis patients with other subtypes). In conclusion, our findings indicate that previous HEV exposure in a region where GT3 is endemic is not associated with glomerulonephritis in general. However, the subgroup of MPGN patients should be investigated in future studies. Furthermore, future studies are needed to investigate whether the observed association between anti-HEV IgG positivity and reduced GFR in glomerulonephritis patients is HEV associated or is an age-related effect.<\/jats:p>","DOI":"10.3390\/pathogens11010018","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T21:40:21Z","timestamp":1640295621000},"page":"18","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lack of Evidence for an Association between Previous HEV Genotype-3 Exposure and Glomerulonephritis in General"],"prefix":"10.3390","volume":"11","author":[{"given":"Sven","family":"Pischke","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"German Center for Infection Research (DZIF), Hamburg-L\u00fcbeck-BorstelPartner Sites, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Tamanaei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mader","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Schulze zur Wiesch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"German Center for Infection Research (DZIF), Hamburg-L\u00fcbeck-BorstelPartner Sites, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Petersen-Benz","sequence":"additional","affiliation":[{"name":"Gesch\u00e4ftsbereich Zentrales Controlling, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munif","family":"Haddad","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-9224","authenticated-orcid":false,"given":"Marylyn M.","family":"Addo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"German Center for Infection Research (DZIF), Hamburg-L\u00fcbeck-BorstelPartner Sites, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Schmidt","sequence":"additional","affiliation":[{"name":"III Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias B.","family":"Huber","sequence":"additional","affiliation":[{"name":"III Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Krebs","sequence":"additional","affiliation":[{"name":"III Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver M.","family":"Steinmetz","sequence":"additional","affiliation":[{"name":"III Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan E.","family":"Turner","sequence":"additional","affiliation":[{"name":"III Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elion","family":"Hoxha","sequence":"additional","affiliation":[{"name":"III Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0682-4476","authenticated-orcid":false,"given":"Thomas","family":"Horvatits","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"German Center for Infection Research (DZIF), Hamburg-L\u00fcbeck-BorstelPartner Sites, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/S0140-6736(16)00272-5","article-title":"Primary glomerulonephritides","volume":"387","author":"Floege","year":"2016","journal-title":"Lancet"},{"key":"ref_2","first-page":"1826","article-title":"Anti-glomerular basement membrane disease: An update on subgroups, pathogenesis and therapies","volume":"34","author":"Segelmark","year":"2019","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transpl. Assoc.\u2014Eur. Ren. Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.23736\/S0026-4806.20.07076-7","article-title":"Cryoglobulinemic glomerulonephritis: Clinical presentation and histological features, diagnostic pitfalls and controversies in the management. State of the art and the experience on a large monocentric cohort treated with B cell depletion therapy","volume":"112","author":"Rossi","year":"2021","journal-title":"Minerva Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1046\/j.1523-1755.1998.00028.x","article-title":"Renal involvement in hepatitis C infection: Cryoglobulinemic glomerulonephritis","volume":"54","year":"1998","journal-title":"Kidney Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jhep.2016.11.016","article-title":"Hepatitis E virus: Infection beyond the liver?","volume":"66","author":"Pischke","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Brehm, T.T., Mazaheri, O., Horvatits, T., L\u00fctgehetmann, M., Schulze zur Wiesch, J., Lohse, A.W., Polywka, S., and Pischke, S. (2021). Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A. Pathogens, 10.","DOI":"10.3390\/pathogens10010060"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/TP.0b013e318245f14c","article-title":"Hepatitis E virus and the kidney in solid-organ transplant patients","volume":"93","author":"Kamar","year":"2012","journal-title":"Transplantation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4103\/0971-4065.34822","article-title":"Hepatitis E associated immune thrombocytopaenia and membranous glomerulonephritis","volume":"11","author":"Ali","year":"2001","journal-title":"Indian J. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jhep.2015.08.034","article-title":"Detection and assessment of infectivity of hepatitis E virus in urine","volume":"64","author":"Geng","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.3201\/eid1810.111756","article-title":"Hepatitis E virus seroprevalence among adults, Germany","volume":"18","author":"Faber","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/jvh.12868","article-title":"Hepatitis E virus seroprevalence, seroincidence and seroreversion in the German adult population","volume":"25","author":"Faber","year":"2018","journal-title":"J. Viral Hepat."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"El-Mokhtar, M.A., Seddik, M.I., Osman, A., Adel, S., Abdel Aziz, E.M., Mandour, S.A., Mohammed, N., Zarzour, M.A., Abdel-Wahid, L., and Radwan, E. (2020). Hepatitis E Virus Mediates Renal Injury via the Interaction between the Immune Cells and Renal Epithelium. Vaccines, 8.","DOI":"10.3390\/vaccines8030454"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/apt.14285","article-title":"Systematic review with meta-analysis: The association between hepatitis E seroprevalence and haemodialysis","volume":"46","author":"Haffar","year":"2017","journal-title":"Aliment. Pharmacol. 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