{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:20:54Z","timestamp":1788801654766,"version":"build-2803163510"},"reference-count":55,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009687","name":"Wroclaw Medical University","doi-asserted-by":"publisher","award":["STM.D230.16.038"],"award-info":[{"award-number":["STM.D230.16.038"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009687","name":"Wroclaw Medical University","doi-asserted-by":"publisher","award":["SUB.D230.21.102"],"award-info":[{"award-number":["SUB.D230.21.102"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Urinary infections related to the presence of bacterial biofilm on catheters are responsible for loss of patients\u2019 health and, due to their high frequency of occurrence, generate a significant economic burden for hospitals. Klebsiella pneumoniae is a pathogen frequently isolated from this type of infection. In this study, using a cohesive set of techniques performed under stationary and flow conditions, we assessed the ability of 120 K. pneumoniae strains to form biofilm on various surfaces, including catheters, and evaluated the usefulness of clinically applied and experimental compounds to remove biofilm. The results of our study indicate the high impact of intraspecies variability with respect to K. pneumoniae biofilm formation and its susceptibility to antimicrobials and revealed the crucial role of mechanical flushing out of the biofilm from the catheter\u2019s surface with use of locally active antimicrobials. Therefore, our work, although of in vitro character, may be considered an important step in the direction of efficient reduction of K. pneumoniae biofilm-related hospital infections associated with the presence of urine catheters.<\/jats:p>","DOI":"10.3390\/pathogens11010042","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T20:49:38Z","timestamp":1641242978000},"page":"42","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The In Vitro Ability of Klebsiella pneumoniae to Form Biofilm and the Potential of Various Compounds to Eradicate It from Urinary Catheters"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-468X","authenticated-orcid":false,"given":"Monika","family":"Oleksy-Wawrzyniak","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7559-8903","authenticated-orcid":false,"given":"Adam","family":"Junka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-3377","authenticated-orcid":false,"given":"Malwina","family":"Bro\u017cyna","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-9760","authenticated-orcid":false,"given":"Migda\u0142","family":"Pawe\u0142","sequence":"additional","affiliation":[{"name":"Department of Environment Hygiene and Animal Welfare, Wroclaw University of Environmental and Life Sciences, 51-630 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart\u0142omiej","family":"Kwiek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lazarski University, 02-662 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7656-7244","authenticated-orcid":false,"given":"Maciej","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Drug Form Technology, Faculty of Pharmacy Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6388-7970","authenticated-orcid":false,"given":"Beata","family":"M\u0105czy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzenna","family":"Bartoszewicz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Thambirajoo, M., Maarof, M., Lokanathan, Y., Katas, H., Ghazalli, N.F., Tabata, Y., and Fauzi, M.B. 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