{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:39:30Z","timestamp":1777030770538,"version":"3.51.4"},"reference-count":99,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONICYT scholarship","award":["21210662"],"award-info":[{"award-number":["21210662"]}]},{"DOI":"10.13039\/501100013928","name":"Millennium Institute on Immunology and Immunotherapy","doi-asserted-by":"publisher","award":["P09\/016-F"],"award-info":[{"award-number":["P09\/016-F"]}],"id":[{"id":"10.13039\/501100013928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013928","name":"Millennium Institute on Immunology and Immunotherapy","doi-asserted-by":"publisher","award":["ICN09_016"],"award-info":[{"award-number":["ICN09_016"]}],"id":[{"id":"10.13039\/501100013928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009465","name":"CORFO","doi-asserted-by":"publisher","award":["13CTI-21526\/P4"],"award-info":[{"award-number":["13CTI-21526\/P4"]}],"id":[{"id":"10.13039\/100009465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009465","name":"CORFO","doi-asserted-by":"publisher","award":["13CTI-21526\/P5"],"award-info":[{"award-number":["13CTI-21526\/P5"]}],"id":[{"id":"10.13039\/100009465","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ANID\/FONDECYT","award":["3180570"],"award-info":[{"award-number":["3180570"]}]},{"name":"ANID\/FONDECYT","award":["1190830"],"award-info":[{"award-number":["1190830"]}]},{"name":"Biomedical Research Consortium","award":["CTU06"],"award-info":[{"award-number":["CTU06"]}]},{"name":"Fundaci\u00f3n Copec UC","award":["2019.R.1169"],"award-info":[{"award-number":["2019.R.1169"]}]},{"name":"Fundaci\u00f3n Copec UC","award":["2020.E.1"],"award-info":[{"award-number":["2020.E.1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Respiratory infections are among the major public health burdens, especially during winter. Along these lines, the human respiratory syncytial virus (hRSV) is the principal viral agent causing acute lower respiratory tract infections leading to hospitalization. The pulmonary manifestations due to hRSV infection are bronchiolitis and pneumonia, where the population most affected are infants and the elderly. However, recent evidence suggests that hRSV infection can impact the mother and fetus during pregnancy. Studies have indicated that hRSV can infect different cell types from the placenta and even cross the placenta barrier and infect the fetus. In addition, it is known that infections during the gestational period can lead to severe consequences for the development of the fetus due not only to a direct viral infection but also because of maternal immune activation (MIA). Furthermore, it has been described that the development of the central nervous system (CNS) of the fetus can be affected by the inflammatory environment of the uterus caused by viral infections. Increasing evidence supports the notion that hRSV could invade the CNS and infect nervous cells, such as microglia, neurons, and astrocytes, promoting neuroinflammation. Moreover, it has been described that the hRSV infection can provoke neurological manifestations, including cognitive impairment and behavioral alterations. Here, we will review the potential effect of hRSV in brain development and the potential long-term neurological sequelae.<\/jats:p>","DOI":"10.3390\/pathogens11010047","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T20:21:56Z","timestamp":1641759716000},"page":"47","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Potential Neurocognitive Symptoms Due to Respiratory Syncytial Virus Infection"],"prefix":"10.3390","volume":"11","author":[{"given":"Catalina A.","family":"Andrade","sequence":"first","affiliation":[{"name":"Department of Molecular and Microbiology, Faculty of Biological Science, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8331010, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-5263","authenticated-orcid":false,"given":"Alexis M.","family":"Kalergis","sequence":"additional","affiliation":[{"name":"Department of Molecular and Microbiology, Faculty of Biological Science, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8331010, Chile"},{"name":"Departamento de Endocrinolog\u00eda, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8331010, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-7544","authenticated-orcid":false,"given":"Karen","family":"Bohmwald","sequence":"additional","affiliation":[{"name":"Department of Molecular and Microbiology, Faculty of Biological Science, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8331010, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"ref_1","first-page":"204993611986579","article-title":"Respiratory syncytial virus: Diagnosis, prevention and management","volume":"6","author":"Barr","year":"2019","journal-title":"Ther. 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