{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:09:13Z","timestamp":1790881753659,"version":"4.1.0"},"reference-count":82,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>(1) Background: Trichosporon species have emerged as important opportunistic fungal pathogens, with Trichosporon asahii being the leading and most frequent cause of invasive disease. (2) Methods: We performed a global review focused on invasive trichosporonosis in neonates and pediatric patients with malignancies or hematologic disorders. We reviewed case reports and case series of trichosporonosis due to T. asahii published since 1994, the year of the revised taxonomic classification. (3) Results: Twenty-four cases of invasive trichosporonosis were identified in neonates with the presence of central venous catheter and use of broad-spectrum antibiotics recognized as the main predisposing factors. Thirty-two cases were identified in children with malignancies or hematologic disorders, predominantly with severe neutropenia. Trichosporon asahii was isolated from blood in 24\/32 (75%) pediatric cases. Cutaneous involvement was frequently observed in invasive trichosporonosis. Micafungin was the most commonly used prophylactic agent (9\/22; 41%). Ten patients receiving prophylactic echinocandins were identified with breakthrough infections. A favorable outcome was reported in 12\/16 (75%) pediatric patients receiving targeted monotherapy with voriconazole or combined with liposomal amphotericin B. Overall mortality in neonates and children with malignancy was 67% and 60%, respectively. (4) Conclusions: Voriconazole is advocated for the treatment of invasive trichosporonosis given the intrinsic resistance to echinocandins and poor susceptibility to polyenes.<\/jats:p>","DOI":"10.3390\/pathogens11020242","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T20:34:45Z","timestamp":1644784485000},"page":"242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders"],"prefix":"10.3390","volume":"11","author":[{"given":"Maria","family":"Kourti","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, 3rd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Hippokration General Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0202-364X","authenticated-orcid":false,"given":"Emmanuel","family":"Roilides","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, 3rd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Hippokration General Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1128\/CMR.00003-11","article-title":"Current knowledge of Trichosporon spp. and Trichosporonosis","volume":"24","author":"Colombo","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijid.2015.09.009","article-title":"Molecular evidence that the opportunistic fungal pathogen Trichosporon asahii is part of the normal fungal microbiota of the human gut based on rRNA genotyping","volume":"39","author":"Cho","year":"2015","journal-title":"Int. J. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1348-0421.2011.00341.x","article-title":"The opportunistic yeast pathogen Trichosporon asahii colonizes the skin of healthy individuals: Analysis of 380 healthy individuals by age and gender using a nested polymerase chain reaction assay","volume":"55","author":"Zhang","year":"2011","journal-title":"Microbiol. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11046-008-9136-x","article-title":"Update on the genus Trichosporon","volume":"166","author":"Chaves","year":"2008","journal-title":"Mycopathologia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/sj.bmt.1702231","article-title":"Trichosporon beigelii: A life-threatening pathogen in immunocompromised hosts","volume":"25","author":"Erer","year":"2000","journal-title":"Bone Marrow Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1080\/00365540410017563","article-title":"Trichosporonosis in a tertiary care cancer center: Risk factors, changing spectrum and determinants of outcome","volume":"36","author":"Kontoyiannis","year":"2004","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.4049\/jimmunol.145.7.2147","article-title":"Mechanisms accounting for lymphocytic alveolitis in hypersensitivity pneumonitis","volume":"45","author":"Trentin","year":"1990","journal-title":"J. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/00039896.1989.9935900","article-title":"Prevention of summer-type hypersensitivity pneumonitis: Effect of elimination of Trichosporon cutaneum from the patients\u2019 homes","volume":"44","author":"Yoshida","year":"1989","journal-title":"Arch. Environ. Health."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1067\/S0190-9622(03)00459-6","article-title":"White piedra: Further evidence of a synergistic infection","volume":"49","author":"Youker","year":"2003","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1365-4362.1984.tb05704.x","article-title":"White piedra. A frequently misdiagnosed infection of hair","volume":"23","author":"Gold","year":"1984","journal-title":"Int. J. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1099\/00222615-3-1-191","article-title":"Brain abscess due to Trichosporon cutaneum","volume":"3","author":"Watson","year":"1970","journal-title":"J. Med. Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e01505-18","DOI":"10.1128\/JCM.01505-18","article-title":"Invasive Infections Due to Trichosporon: Species Distribution, Genotyping, and Antifungal Susceptibilities from a Multicenter Study in China","volume":"57","author":"Guo","year":"2019","journal-title":"J. Clin. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1128\/JCM.43.4.1818-1828.2005","article-title":"GIMEMA Infection Program. Invasive infections caused by Trichosporon species and Geotrichum capitatum in patients with hematological malignancies: A retrospective multicenter study from Italy and review of the literature","volume":"43","author":"Girmenia","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1086\/599614","article-title":"Invasive trichosporonosis caused by Trichosporon asahii and other unusual Trichosporon species at a medical center in Taiwan","volume":"49","author":"Ruan","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00005792-198607000-00005","article-title":"Trichosporonosis in patients with neoplastic disease","volume":"65","author":"Walsh","year":"1986","journal-title":"Medicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1056\/NEJMoa010494","article-title":"Fluconazole prophylaxis against fungal colonization and infection in preterm infants","volume":"345","author":"Kaufman","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1017\/S0950268820001624","article-title":"Epidemiological study of Trichosporon asahii infections over the past 23 years","volume":"148","author":"Li","year":"2020","journal-title":"Epidemiol. Infect."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"E35","DOI":"10.1086\/341305","article-title":"Breakthrough trichosporonosis in a bone marrow transplant recipient receiving caspofungin acetate","volume":"35","author":"Goodman","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s005200050221","article-title":"Hematogenous trichosporonosis in cancer patients: Report of 12 cases including 5 during prophylaxis with itraconazol","volume":"7","author":"Krcmery","year":"1999","journal-title":"Support. Care Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/1319-3767.58768","article-title":"Trichosporon peritonitis following duodenal perforation","volume":"16","author":"Kalawat","year":"2010","journal-title":"Saudi. J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1086\/317463","article-title":"Trichosporon beigelii funguria in renal transplant recipients","volume":"31","author":"Lussier","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Larcher, R., Platon, L., Amalric, M., Brunot, V., Besnard, N., Benomar, R., Daubin, D., Ceballos, P., Rispail, P., and Lachaud, L. (2021). Emerging Invasive Fungal Infections in Critically Ill Patients: Incidence, Outcomes and Prognosis Factors, a Case-Control Study. J. Fungi, 7.","DOI":"10.3390\/jof7050330"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s00467-004-1731-6","article-title":"Marked renal damage in a child with hydronephrosis infected by Trichosporon asahii","volume":"20","author":"Mori","year":"2005","journal-title":"Pediatr. Nephrol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/iid3.250","article-title":"Disseminated Trichosporon asahii infection in a combined liver-kidney transplant recipient successfully treated with voriconazole","volume":"7","author":"Sah","year":"2019","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e22584","DOI":"10.1097\/MD.0000000000022584","article-title":"Prosthetic valve endocarditis by Trichosporon mucoides: A case report and review of literature","volume":"99","author":"Oh","year":"2020","journal-title":"Medicine"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Mehler, K., Cornely, O., Seifert, H., Zweigner, J., Janssen, S., and Oberthuer, A. (2021). Molds and More: Rare Fungal Infections in Preterm Infants <24 Weeks of Gestation. Pediatr. Infect. Dis. J., Epub ahead of print.","DOI":"10.1097\/INF.0000000000003407"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0956462413487716","article-title":"Invasive trichosporonosis in an AIDS patient: Case report and review of the literature","volume":"25","author":"Roman","year":"2014","journal-title":"Int. J. STD AIDS"},{"key":"ref_28","first-page":"459","article-title":"Disseminated Trichosporon spp infection in preterm newborns: A case report","volume":"85","author":"Pereira","year":"2009","journal-title":"J. Pediatr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1439-0507.2002.00736.x","article-title":"Trichosporon mucoides infection in three premature newborns","volume":"45","author":"Cetin","year":"2002","journal-title":"Mycoses"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00006454-200202000-00018","article-title":"Trichosporon asahii: An unusual cause of invasive infection in neonates","volume":"21","author":"Panagopoulou","year":"2002","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_31","first-page":"213","article-title":"Trichosporon asahii fatal infection in a preterm newborn","volume":"25","year":"2008","journal-title":"Rev. Chilena. Infectol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/sj.jp.7211077","article-title":"Mixed infection with unusual fungi and staphylococcal species in two extremely premature neonates","volume":"24","author":"Maheshwari","year":"2004","journal-title":"J. Perinatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1055\/s-2003-42337","article-title":"Disseminated Trichosporon asahii infection in a preterm","volume":"20","author":"Yildiran","year":"2003","journal-title":"Am. J. Perinatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00006454-199302000-00009","article-title":"Neonatal Trichosporon beigelii infection: Report of a cluster of cases in a neonatal intensive care unit","volume":"12","author":"Fisher","year":"1993","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1097\/00007611-199212000-00022","article-title":"Trichosporon beigelii: A potential cause of sepsis in premature infants","volume":"85","author":"Giacoia","year":"1992","journal-title":"South Med. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-2007-994109","article-title":"Trichosporon beigelii, a new neonatal pathogen","volume":"14","author":"Yoss","year":"1997","journal-title":"Am. J. Perinatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0163-4453(98)93630-1","article-title":"Disseminated neonatal Trichosporon beigelii infection: Successful treatment with liposomal amphotericin B","volume":"36","author":"Sweet","year":"1998","journal-title":"J. Infect."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Noni, M., Stathi, A., Velegraki, A., Malamati, M., Kalampaliki, A., Zachariadou, L., and Michos, A. (2020). Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study. J. Fungi, 6.","DOI":"10.3390\/jof6040194"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s13312-012-0137-y","article-title":"A fatal outbreak of Trichosporon asahii sepsis in a neonatal intensive care Unit","volume":"49","author":"Vashishtha","year":"2012","journal-title":"Indian Pediatr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1179\/2047773215Y.0000000019","article-title":"Multidrug-resistant Trichosporon: An unusual fungal sepsis in preterm neonates","volume":"109","author":"Basu","year":"2015","journal-title":"Pathog. Glob. Health"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e193","DOI":"10.1097\/MPH.0000000000001420","article-title":"Chemoport-related Fungemia Caused by Trichosporon asahii","volume":"42","author":"Raju","year":"2020","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/cup.13397","article-title":"Disseminated trichosporonosis with atypical histologic findings in a patient with acute lymphocytic leukemia","volume":"46","author":"Galligan","year":"2019","journal-title":"J. Cutan. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/MPH.0000000000000876","article-title":"An Unusual Cause of Fever and Rash in a Child with Severe Aplastic Anemia","volume":"40","author":"Lee","year":"2018","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1111\/pde.13359","article-title":"Fatal disseminated Trichosporon asahii fungemia in a child with acute lymphoblastic leukemia and a morbilliform eruption","volume":"35","author":"Nguyen","year":"2018","journal-title":"Pediatr. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/jpids\/pix031","article-title":"Trichosporonosis in Pediatric Patients with a Hematologic Disorder","volume":"7","author":"Foster","year":"2018","journal-title":"J. Pediatric. Infect. Dis. Soc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.idcr.2015.09.007","article-title":"Trichosporon fungemia in a pediatric patient with acute lymphoblastic leukemia","volume":"2","author":"Maxfield","year":"2015","journal-title":"IDCases"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/pde.12586","article-title":"Multiple Erythematous Papules in a Child with Neutropenia","volume":"32","author":"Oh","year":"2015","journal-title":"Pediatr. Dermatol."},{"key":"ref_48","first-page":"651315","article-title":"Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully","volume":"2015","author":"Tanyildiz","year":"2015","journal-title":"Case Rep. Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3109\/08880018.2013.851754","article-title":"Trichosporon asahii, sepsis, and secondary hemophagocytic lymphohistiocytosis in children with hematologic malignancy","volume":"31","author":"Karapinar","year":"2014","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e528","DOI":"10.1097\/MPH.0000000000000173","article-title":"Microbiologically documented fungal infections in pediatric patients with acute myeloid leukemia: 12.5-year experience at a single institution","volume":"36","author":"Agarwal","year":"2014","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jmii.2013.01.003","article-title":"Trichosporon asahii sepsis in a patient with pediatric malignancy","volume":"49","author":"Cengiz","year":"2016","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/bmt.2010.96","article-title":"Terui, K.; Sasaki, S.; Kamio, T.; Sato, T.; Ito, E. Voriconazole for both successful treatment of disseminated Trichosporon asahii infection and subsequent cord blood transplantation in an infant with acute myelogenous leukemia","volume":"46","author":"Kudo","year":"2011","journal-title":"Bone Marrow Transplant."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1155\/2008\/787689","article-title":"Fatal disseminated Trichosporon asahii infection in a child with acute lymphoblastic leukemia","volume":"19","author":"Thibeault","year":"2008","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/MPH.0b013e3181864aa7","article-title":"Early detection of breakthrough trichosporonosis by serum PCR in a cord blood transplant recipient being prophylactically treated with voriconazole","volume":"30","author":"Hosoki","year":"2008","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1097\/INF.0b013e318179260d","article-title":"Quantitative PCR assay used to monitor serum Trichosporon asahii DNA concentrations in disseminated trichosporonosis","volume":"27","author":"Tsuji","year":"2008","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_56","first-page":"426","article-title":"Disseminated, fatal Trichosporon asahii infection in a bone marrow transplant recipient","volume":"39","author":"Ghiasian","year":"2006","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/01.mph.0000164865.70522.d7","article-title":"Fungemia due to Trichosporon asahii in a neutropenic child refractory to amphotericin B: Clearance with voriconazole","volume":"27","author":"Antachopoulos","year":"2005","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1086\/340983","article-title":"Chronic disseminated Trichosporon asahii infection in a leukemic child","volume":"35","author":"Meyer","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1439-0507.1996.tb00124.x","article-title":"Disseminated infection with Trichosporon asahii","volume":"39","author":"Itoh","year":"1996","journal-title":"Mycoses"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1600-0609.2010.01410.x","article-title":"Fatal Trichosporon fungemia in patients with hematologic malignancies","volume":"84","author":"Suzuki","year":"2010","journal-title":"Eur. J. Haematol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1473-3099(10)70218-8","article-title":"Emerging opportunistic yeast infections","volume":"11","author":"Miceli","year":"2011","journal-title":"Lancet Infect. Dis"},{"key":"ref_62","first-page":"1629","article-title":"Invasive trichosporon infection: A systematic review on a re-emerging fungal pathogen","volume":"7","author":"Hennequin","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/ejh.12910","article-title":"Retrospective study on the incidence and outcome of proven and probable invasive fungal infections in high-risk pediatric onco-hematological patients","volume":"99","author":"Cesaro","year":"2017","journal-title":"Eur. J. Haematol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jinf.2011.11.002","article-title":"Rare opportunistic (non-Candida, non-Cryptococcus) yeast bloodstream infections in patients with cancer","volume":"64","author":"Chitasombat","year":"2012","journal-title":"J. Infect."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1586\/eri.11.1","article-title":"Invasive fungal infections in the pediatric population","volume":"9","author":"Lehrnbecher","year":"2011","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.tim.2020.01.007","article-title":"Tracing the Origin of Invasive Fungal Infections","volume":"28","author":"Papon","year":"2020","journal-title":"Trends Microbiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/infdis\/166.1.121","article-title":"Experimental Trichosporon infection in persistently granulocytopenic rabbits: Implications for pathogenesis, diagnosis, and treatment of an emerging opportunistic mycosis","volume":"66","author":"Walsh","year":"1992","journal-title":"J. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1128\/AAC.00556-06","article-title":"Biofilm formation by the emerging fungal pathogen Trichosporon asahii: Development, architecture, and antifungal resistance","volume":"50","author":"Pompilio","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1128\/JCM.40.5.1826-1830.2002","article-title":"Sequence analysis of the ribosomal DNA intergenic spacer 1 regions of Trichosporon species","volume":"40","author":"Sugita","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e375","DOI":"10.1016\/S1473-3099(21)00203-6","article-title":"Global guideline for the diagnosis and management of rare yeast infections: An initiative of the ECMM in cooperation with ISHAM and AS.M","volume":"21","author":"Chen","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1086\/500323","article-title":"Breakthrough trichosporonosis in patients with hematologic malignancies receiving micafungin","volume":"42","author":"Matsue","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1470-9465.2004.00839.x","article-title":"Infections due to emerging and uncommon medically important fungal pathogens","volume":"10","author":"Walsh","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1128\/jcm.28.7.1616-1622.1990","article-title":"Trichosporon beigelii, an emerging pathogen resistant to amphotericin B","volume":"28","author":"Walsh","year":"1990","journal-title":"J. Clin. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/clind\/15.5.781","article-title":"Azole therapy for trichosporonosis: Clinical evaluation of eight patients, experimental therapy for murine infection, and review","volume":"15","author":"Anaissie","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.riam.2017.02.008","article-title":"Biofilm formation and antifungal susceptibility of Trichosporon asahii isolates from Mexican patients","volume":"35","author":"Montoya","year":"2018","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"ofv141","DOI":"10.1093\/ofid\/ofv141","article-title":"Epidemiology and Outcome of Trichosporon Fungemia: A Review of 185 Reported Cases From 1975 to 2014","volume":"2","author":"Liao","year":"2015","journal-title":"Open Forum Infect. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/1469-0691.12360","article-title":"ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections","volume":"20","author":"Arendrup","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1007\/s10096-002-0841-y","article-title":"Use of voriconazole to successfully treat disseminated Trichosporon asahii infection in a patient with acute myeloid leukaemia","volume":"21","author":"Fournier","year":"2002","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1399-3062.2011.00670.x","article-title":"Successful treatment of Trichosporon fungemia in a patient with refractory acute myeloid leukemia using voriconazole combined with liposomal amphotericin B","volume":"14","author":"Hosokawa","year":"2012","journal-title":"Transpl. Infect. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1093\/jac\/dkab085","article-title":"Epidemiology, clinical aspects, outcomes and prognostic factors associated with Trichosporon fungaemia: Results of an international multicentre study carried out at 23 medical centres","volume":"76","author":"Francisco","year":"2021","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1080\/1040841X.2021.1921695","article-title":"Multidrug-resistant Trichosporon species: Underestimated fungal pathogens posing imminent threats in clinical settings","volume":"47","author":"Arastehfar","year":"2021","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","article-title":"European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group; National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group","volume":"46","author":"Walsh","year":"2008","journal-title":"Clin. Infect. 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