{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:32:58Z","timestamp":1784824378748,"version":"3.55.0"},"reference-count":18,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>In this report, we describe the course and successful treatment of a case of complicated infective endocarditis (IE). A patient presented with a high-grade, irregular fever with chills lasting at least 2 months along with dyspnoea, chest pain, fatigue, weight loss, and night sweats during the previous 3 months. As well as cardiac congenital disorders, he was found to have Granulicatella adiacens infective aortic valve endocarditis, presumably transmitted from the oral cavity niche. Validated metagenomic 16S rDNA next generation sequencing was used to perform taxonomic identification, allowing for specific adequate antibiotic therapy instead of empiric therapy. This paper highlights the critical role of rapid taxonomic identification of nutritionally variant streptococci and the benefit of proper IE treatment in avoiding relapses or fatal complications.<\/jats:p>","DOI":"10.3390\/pathogens11030295","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T20:48:33Z","timestamp":1645994913000},"page":"295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The First Case of Granulicatella adiacens Identified from a Resected Heart Valve by Next Generation Sequencing (NGS) in Poland"],"prefix":"10.3390","volume":"11","author":[{"given":"Anna","family":"Podg\u00f3rska","sequence":"first","affiliation":[{"name":"Department of Medical Biology, National Institute of Cardiology, Stefan Cardinal Wyszy\u0144ski State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kordybach-Prokopiuk","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Diseases, National Institute of Cardiology, Stefan Cardinal Wyszy\u0144ski State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Jaworska-Wilczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Valvular Heart Disease, National Institute of Cardiology, Stefan Cardinal Wyszy\u0144ski State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Diseases, National Institute of Cardiology, Stefan Cardinal Wyszy\u0144ski State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Biernacka","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Diseases, National Institute of Cardiology, Stefan Cardinal Wyszy\u0144ski State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Ku\u015bmierski","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery and Transplantology, National Institute of Cardiology, Stefan Cardinal Wyszy\u0144ski State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9680-1632","authenticated-orcid":false,"given":"Robert","family":"Kuthan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Medical University of Warsaw, 5 Cha\u0142ubi\u0144skiego Street, 02-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0536-886X","authenticated-orcid":false,"given":"Tomasz","family":"Hryniewiecki","sequence":"additional","affiliation":[{"name":"Department of Valvular Heart Disease, National Institute of Cardiology, Stefan Cardinal Wyszy\u0144ski State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Luty\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, National Institute of Cardiology, Stefan Cardinal Wyszy\u0144ski State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/191728a0","article-title":"Spontaneous development of L forms of streptococci requiring secretions of other bacteria or sulphydryl compounds for normal growth","volume":"191","author":"Frenkel","year":"1961","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S1413-8670(10)70124-0","article-title":"Native valve endocarditis and femoral embolism due to Granulicatella adiacens: A rare case report","volume":"14","author":"Vandana","year":"2010","journal-title":"Braz. 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