{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:38Z","timestamp":1787029238791,"version":"build-2736575974"},"reference-count":63,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Sporothrix schenckii is a worldwide-distributed thermally dimorphic fungus, which usually causes a subacute to chronic infection through traumatic implantation or inoculation of its infectious propagules. The fungus encompasses a group of phylogenetically closely related species, thus named the S. schenckii complex, of which S. schenckiisensu stricto and S. brasiliensis are main causative species of sporotrichosis. Owing to a multifaceted molecular dynamic, the S. schenckii complex can switch between the mycelium and the yeast form. This characteristic along with a varying cell wall composition account for significant species-specific differences in the host range, virulence, and susceptibility to antifungal drugs. While culture remains the gold standard to diagnose sporotrichosis, polymerase chain reaction (PCR) or matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry-based methods have become an essential for accurate species identification in many clinical laboratories. If directly applied on tissue samples, molecular methods are helpful to improve both sensitivity of and time to the etiological diagnosis of sporotrichosis. This mini-review aims to put together the old and new knowledge on the S. schenckii complex biology and identification, with particular emphasis on the laboratory diagnosis-related aspects of disease.<\/jats:p>","DOI":"10.3390\/pathogens11030297","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T20:48:33Z","timestamp":1645994913000},"page":"297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Old and New Insights into Sporothrix schenckii Complex Biology and Identification"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4757-7256","authenticated-orcid":false,"given":"Elena","family":"De Carolis","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunella","family":"Posteraro","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-7059","authenticated-orcid":false,"given":"Maurizio","family":"Sanguinetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. 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Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1128\/JCM.00808-07","article-title":"Sporothrix brasiliensis, S. globosa, and S. mexicana, three new Sporothrix species of clinical interest","volume":"45","author":"Marimon","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/mmy\/myu062","article-title":"Global epidemiology of sporotrichosis","volume":"53","author":"Chakrabarti","year":"2015","journal-title":"Med. Mycol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3389\/fmicb.2017.00843","article-title":"Sporothrix schenckii sensu stricto and Sporothrix brasiliensis are differentially recognized by human peripheral blood mononuclear cells","volume":"8","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1469-0691.2009.02824.x","article-title":"Different virulence levels of the species of Sporothrix in a murine model","volume":"15","author":"Capilla","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/mmy\/myu056","article-title":"Susceptibility of Sporothrix brasiliensis isolates to amphotericin B, azoles, and terbinafine","volume":"53","author":"Rodrigues","year":"2015","journal-title":"Med. Mycol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bonifaz, A., and Tirado-S\u00e1nchez, A. (2017). Cutaneous disseminated and extracutaneous sporotrichosis: Current status of a complex disease. J. Fungi, 3.","DOI":"10.3390\/jof3010006"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Queiroz-Telles, F., Buccheri, R., and Benard, G. (2019). Sporotrichosis in immunocompromised hosts. J. Fungi, 5.","DOI":"10.3390\/jof5010008"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Do Monte Alves, M., Pipolo Milan, E., da Silva-Rocha, W.P., Soares de Sena da Costa, A., Ara\u00fajo Maciel, B., Cavalcante Vale, P.H., de Albuquerque, P.R., Lopes Lima, S., Salles de Azevedo Melo, A., and Messias Rodrigues, A. (2020). Fatal pulmonary sporotrichosis caused by Sporothrix brasiliensis in Northeast Brazil. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008141"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"De Oliveira Bento, A., de Sena Costa, A.S., Lima, S.L., do Monte Alves, M., de Azevedo Melo, A.S., Rodrigues, A.M., da Silva-Rocha, W.P., Milan, E.P., and Chaves, G.M. (2021). The spread of cat-transmitted sporotrichosis due to Sporothrix brasiliensis in Brazil towards the Northeast region. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0009693"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Rodrigues, A.M., de Melo Teixeira, M., de Hoog, G.S., Schubach, T.M., Pereira, S.A., Fernandes, G.F., Bezerra, L.M., Felipe, M.S., and de Camargo, Z.P. (2013). Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002281"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Teixeira, M.M., de Almeida, L.G., Kubitschek-Barreira, P., Alves, F.L., Kioshima, E.S., Abadio, A.K., Fernandes, L., Derengowski, L.S., Ferreira, K.S., and Souza, R.C. (2014). Comparative genomics of the major fungal agents of human and animal sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis. BMC Genom., 29.","DOI":"10.1186\/1471-2164-15-943"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3767\/003158515X687416","article-title":"Phylogeography and evolutionary patterns in Sporothrix spanning more than 14 000 human and animal case reports","volume":"35","author":"Zhang","year":"2015","journal-title":"Persoonia"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Arenas, R., S\u00e1nchez-Cardenas, C.D., Ramirez-Hobak, L., Ru\u00edz Arriaga, L.F., and Vega Memije, M.E. (2018). Sporotrichosis: From KOH to molecular biology. J. Fungi, 4.","DOI":"10.3390\/jof4020062"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.riam.2013.09.008","article-title":"Molecular identification of the Sporothrix schenckii complex","volume":"31","author":"Oliveira","year":"2014","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3109\/13693780802695520","article-title":"A comparative serological study of the SsCBF antigenic fraction isolated from three Sporothrix schenckii strains","volume":"47","author":"Benvenuto","year":"2009","journal-title":"Med. Mycol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"115131","DOI":"10.1016\/j.diagmicrobio.2020.115131","article-title":"Serological tests using Sporothrix species antigens for the accurate diagnosis of sporotrichosis: A meta-analysis","volume":"98","author":"Mendoza","year":"2020","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1590\/abd1806-4841.2017279","article-title":"Sporotrichosis: An update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics","volume":"92","author":"Macedo","year":"2017","journal-title":"An. Bras. Dermatol."},{"key":"ref_21","first-page":"153","article-title":"Global ITS diversity in the Sporothrix schenckii complex","volume":"66","author":"Zhou","year":"2013","journal-title":"Fungal Divers."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.diagmicrobio.2014.01.004","article-title":"Genotyping species of the Sporothrix schenckii complex by PCR-RFLP of calmodulin","volume":"78","author":"Rodrigues","year":"2014","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Rodrigues, A.M., de Hoog, G.S., and de Camargo, Z.P. (2015). Molecular diagnosis of pathogenic Sporothrix species. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0004190"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhang, M., Li, F., Li, R., Gong, J., and Zhao, F. (2019). Fast diagnosis of sporotrichosis caused by Sporothrix globosa, Sporothrix schenckii, and Sporothrix brasiliensis based on multiplex real-time PCR. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007219"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/myc.13004","article-title":"Diagnostic value of a nested polymerase chain reaction for diagnosing cutaneous sporotrichosis from paraffin-embedded skin tissue","volume":"62","author":"Hayashi","year":"2019","journal-title":"Mycoses"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"De Carvalho, J.A., Hagen, F., Fisher, M.C., de Camargo, Z.P., and Rodrigues, A.M. (2020). Genome-wide mapping using new AFLP markers to explore intraspecific variation among pathogenic Sporothrix species. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008330"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1128\/JCM.01640-16","article-title":"Identification of molds by matrix-assisted laser desorption ionization-time of flight mass spectrometry","volume":"55","author":"Sanguinetti","year":"2017","journal-title":"J. Clin. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e01263-20","DOI":"10.1128\/JCM.01263-20","article-title":"Update on matrix-assisted laser desorption ionization-time of flight mass spectrometry identification of filamentous fungi","volume":"58","author":"Wilkendorf","year":"2020","journal-title":"J. Clin. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.resmic.2014.12.008","article-title":"Development and optimization of a new MALDI-TOF protocol for identification of the Sporothrix species complex","volume":"166","author":"Oliveira","year":"2015","journal-title":"Res. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Matos, A.M.F., Moreira, L.M., Barczewski, B.F., de Matos, L.X., de Oliveira, J.B.V., Pimentel, M.I.F., Almeida-Paes, R., Oliveira, M.G., Pinto, T.C.A., and Lima, N. (2019). Identification by MALDI-TOF MS of Sporothrix brasiliensis isolated from a subconjunctival infiltrative lesion in an immunocompetent patient. Microorganisms, 8.","DOI":"10.3390\/microorganisms8010022"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cll.2021.03.006","article-title":"Matrix-assisted laser desorption ionization time-of-flight for fungal identification","volume":"41","author":"Lau","year":"2021","journal-title":"Clin. Lab. Med."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Prakash, H., Karuppiah, P.A., Al-Dhabi, N., Prasad, G.S., Badapanda, C., Chakrabarti, A., and Rudramurthy, S.M. (2020). Comparative genomics of Sporothrix species and identification of putative pathogenic-gene determinants. Future Microbiol., 1465\u20131481.","DOI":"10.2217\/fmb-2019-0302"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"565439","DOI":"10.3389\/fmicb.2020.565439","article-title":"Comparative genomic data provide new insight on the evolution of pathogenicity in Sporothrix species","volume":"11","author":"Huang","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"a019794","DOI":"10.1101\/cshperspect.a019794","article-title":"Thermally dimorphic human fungal pathogens--polyphyletic pathogens with a convergent pathogenicity trait","volume":"5","author":"Sil","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/myc.13230","article-title":"Molecular-based assessment of diversity and population structure of Sporothrix spp. clinical isolates from Esp\u00edrito Santo-Brazil","volume":"64","author":"Terra","year":"2021","journal-title":"Mycoses"},{"key":"ref_36","first-page":"mgen000445","article-title":"Transcriptome-wide expression profiling of Sporothrix schenckii yeast and mycelial forms and the establishment of the Sporothrix Genome DataBase","volume":"6","author":"Giosa","year":"2020","journal-title":"Microb. Genom."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3892\/mmr.2021.12285","article-title":"Map of dimorphic switching-related signaling pathways in Sporothrix schenckii based on its transcriptome","volume":"24","author":"Zheng","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lopes-Bezerra, L.M., Walker, L.A., Ni\u00f1o-Vega, G., Mora-Montes, H.M., Neves, G.W.P., Villalobos-Duno, H., Barreto, L., Garcia, K., Franco, B., and Mart\u00ednez-\u00c1lvarez, J.A. (2018). Cell walls of the dimorphic fungal pathogens Sporothrix schenckii and Sporothrix brasiliensis exhibit bilaminate structures and sloughing of extensive and intact layers. PLoS Negl. Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006169"},{"key":"ref_39","first-page":"243","article-title":"Sporothrix schenckii cell wall peptidorhamnomannans","volume":"2","year":"2011","journal-title":"Front. Microbiol."},{"key":"ref_40","first-page":"6","article-title":"Current progress in the biology of members of the Sporothrix schenckii complex following the genomic era","volume":"15","year":"2015","journal-title":"FEMS Yeast Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e75656","DOI":"10.1371\/journal.pone.0075656","article-title":"Differences in cell morphometry, cell wall topography and gp70 expression correlate with the virulence of Sporothrix brasiliensis clinical isolates","volume":"8","author":"Castro","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Carnero, L.C., Salinas-Mar\u00edn, R., Lozoya-P\u00e9rez, N.E., Wrobel, K., Wrobel, K., Mart\u00ednez-Duncker, I., Ni\u00f1o-Vega, G.A., and Mora-Montes, H.M. (2021). The heat shock protein 60 and Pap1 participate in the Sporothrix schenckii-host interaction. J. Fungi, 7.","DOI":"10.3390\/jof7110960"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"8623","DOI":"10.1128\/AEM.02414-12","article-title":"Biosynthesis and functions of a melanoid pigment produced by species of the Sporothrix complex in the presence of L-tyrosine","volume":"78","author":"Frases","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3109\/13693780903453287","article-title":"L-DOPA accessibility in culture medium increases melanin expression and virulence of Sporothrix schenckii yeast cells","volume":"48","author":"Teixeira","year":"2010","journal-title":"Med. Mycol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.3389\/fmicb.2018.02286","article-title":"Extracellular vesicles from Sporothrix brasiliensis are an important virulence factor that induce an increase in fungal burden in experimental sporotrichosis","volume":"9","author":"Ikeda","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"104762","DOI":"10.1016\/j.micinf.2020.09.008","article-title":"Comparative proteomics in the three major human pathogenic species of the genus Sporothrix","volume":"23","author":"Lima","year":"2021","journal-title":"Microbes Infect."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/mmy\/myu069","article-title":"Peroxide sensing and signaling in the Sporothrix schenckii complex: An in silico analysis to uncover putative mechanisms regulating the Hog1 and AP-1 like signaling pathways","volume":"53","author":"Ortega","year":"2015","journal-title":"Med. Mycol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/mmy\/myaa027","article-title":"Analysis of biofilm formation by Sporothrix schenckii","volume":"59","year":"2021","journal-title":"Med. Mycol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.drup.2004.09.002","article-title":"Candida biofilm resistance","volume":"7","author":"Mukherjee","year":"2004","journal-title":"Drug Resist. Updates"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/myc.13141","article-title":"Susceptibility testing of clinical isolates of Sporothrix globosa in Shandong, China","volume":"63","author":"Bao","year":"2020","journal-title":"Mycoses"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s42770-020-00307-z","article-title":"Antifungal resistance on Sporothrix species: An overview","volume":"52","author":"Waller","year":"2021","journal-title":"Braz. J. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11046-018-0310-5","article-title":"Molecular identification and antifungal susceptibility of clinical isolates of Sporothrix schenckii complex in Medellin, Colombia","volume":"184","author":"Alzate","year":"2019","journal-title":"Mycopathologia"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Rodrigues, A.M., de Hoog, G.S., de C\u00e1ssia Pires, D., Brihante, R.S., Sidrim, J.J., Gadelha, M.F., Colombo, A.L., and de Camargo, Z.P. (2014). Genetic diversity and antifungal susceptibility profiles in causative agents of sporotrichosis. BMC Infect. Dis., 14.","DOI":"10.1186\/1471-2334-14-219"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/mmy\/myx043","article-title":"Antifungal susceptibility of Sporothrix schenckii complex biofilms","volume":"56","author":"Brilhante","year":"2018","journal-title":"Med. Mycol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbapap.2017.10.003","article-title":"In silico analysis of cytochrome P450 monooxygenases in chronic granulomatous infectious fungus Sporothrix schenckii: Special focus on CYP51","volume":"1866","author":"Matowane","year":"2018","journal-title":"Biochim. Biophys. Acta Proteins Proteom."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e01057-17","DOI":"10.1128\/AAC.01057-17","article-title":"Multicenter, international study of MIC\/MEC distributions for definition of epidemiological cutoff values for Sporothrix species identified by molecular methods","volume":"61","author":"Abreu","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_57","unstructured":"Clinical and Laboratory Standards Institute (CLSI) (2012). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts, Clinical and Laboratory Standards Institute. Fourth Informational Supplement. CLSI document M27-S4."},{"key":"ref_58","unstructured":"Clinical and Laboratory Standards Institute (CLSI) (2008). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi, Clinical and Laboratory Standards Institute. Approved Standard\u2014Second Edition. CLSI document M38-A2."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1139\/w06-040","article-title":"In vitro susceptibility of isolates of Sporothrix schenckii to amphotericin B, itraconazole, and terbinafine: Comparison of yeast and mycelial forms","volume":"52","author":"Kohler","year":"2006","journal-title":"Can. J. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1093\/mmy\/myx103","article-title":"Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents","volume":"56","author":"Zhang","year":"2018","journal-title":"Med. Mycol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Friedman, D.Z.P., and Schwartz, I.S. (2019). Emerging fungal infections: New patients, new patterns, and new pathogens. J. Fungi, 5.","DOI":"10.3390\/jof5030067"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Rossow, J.A., Queiroz-Telles, F., Caceres, D.H., Beer, K.D., Jackson, B.R., Pereira, J.G., Ferreira Gremi\u00e3o, I.D., and Pereira, S.A. (2020). A one health approach to combatting Sporothrix brasiliensis: Narrative review of an emerging zoonotic fungal pathogen in South America. J. Fungi, 6.","DOI":"10.3390\/jof6040247"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"101199","DOI":"10.1016\/j.mycmed.2021.101199","article-title":"Can the essential oil of rosemary (Rosmarinus officinalis Linn.) protect rats infected with itraconazole-resistant Sporothrix brasiliensis from fungal spread?","volume":"31","author":"Waller","year":"2021","journal-title":"J. Mycol. Med."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/3\/297\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:27:51Z","timestamp":1760135271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/3\/297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":63,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["pathogens11030297"],"URL":"https:\/\/doi.org\/10.3390\/pathogens11030297","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,25]]}}}