{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:55:57Z","timestamp":1760151357683,"version":"build-2065373602"},"reference-count":108,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The appearance and spread of parasitic diseases around the world aroused the interest of the scientific community to discover new animal models for improving the quality and specificity of surveys. Calomys callosus is a rodent native to South America, an easy handling model, with satisfactory longevity and reproducibility. C. callosus is susceptible to toxoplasmosis and can be used as experimental model for the study the pathogenesis, treatment, vertical transmission, and ocular toxoplasmosis. C. callosus can also be used to study cutaneous and visceral leishmaniasis, as the animals present cutaneous lesions, as well as parasites in the organs. C. callosus has epidemiological importance in Chagas disease, and since it is a Trypanosoma cruzi natural host in which rodents show high parasitemia and lethality, they are also effective as a model of congenital transmission. In the study of schistosomiasis, Schistosoma mansoni was proven to be a C. callosus natural host; thus, this rodent is a great model for fibrosis, hepatic granulomatous reaction, and celloma associated with lymphomyeloid tissue (CALT) during S. mansoni infection. In this review, we summarize the leading studies of parasitic diseases that used C. callosus as a rodent experimental model, describing the main uses and characteristics that led them to be considered an effective model.<\/jats:p>","DOI":"10.3390\/pathogens11030369","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:34:27Z","timestamp":1647812067000},"page":"369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Calomys callosus: An Experimental Animal Model Applied to Parasitic Diseases Investigations of Public Health Concern"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-6433","authenticated-orcid":false,"given":"Rafael Borges","family":"Rosa","sequence":"first","affiliation":[{"name":"Rodents Animal Facilities Complex, Federal University of Uberlandia, Uberlandia 38400-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mylla Spirandelli da","family":"Costa","sequence":"additional","affiliation":[{"name":"Rodents Animal Facilities Complex, Federal University of Uberlandia, Uberlandia 38400-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1978-1658","authenticated-orcid":false,"given":"Samuel Cota","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia 38405-318, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilene Ferreira de","family":"Castro","sequence":"additional","affiliation":[{"name":"Rodents Animal Facilities Complex, Federal University of Uberlandia, Uberlandia 38400-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-312X","authenticated-orcid":false,"given":"Willyenne Mar\u00edlia","family":"Dantas","sequence":"additional","affiliation":[{"name":"Institute Aggeu Magalh\u00e3es, Fiocruz Pernambuco, Recife 50740-465, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-2583","authenticated-orcid":false,"given":"Eloisa Am\u00e1lia Vieira","family":"Ferro","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia 38405-318, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murilo Vieira da","family":"Silva","sequence":"additional","affiliation":[{"name":"Rodents Animal Facilities Complex, Federal University of Uberlandia, Uberlandia 38400-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"ref_1","unstructured":"Moojen, J. 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