{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:30:10Z","timestamp":1772253010002,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["671055"],"award-info":[{"award-number":["671055"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research for Health in Humanitarian Crisis (R2HC) ELRHA","award":["no grant number"],"award-info":[{"award-number":["no grant number"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>A two-phase survey of epilepsy was conducted in selected villages in Mundri West and East Counties (26 June\u20138 July, 2021), an onchocerciasis-endemic area in Western Equatoria State in South Sudan. In the first phase, households were visited by a trained research team to identify persons suspected to have epilepsy. In the second phase, persons suspected to have epilepsy were interviewed and examined by a clinician to confirm the diagnosis. A total of 364 households agreed to participate in the survey, amounting to 2588 individuals. The epilepsy screening questionnaire identified 91 (3.5%) persons with suspected epilepsy, of whom the diagnosis of epilepsy was confirmed by a clinician in 86 (94.5%). The overall prevalence of confirmed epilepsy was 3.3% (95% CI: 2.7\u20134.1%), and of nodding syndrome was 0.9% (95% CI: 0.6\u20131.4%). In 61 (16.8%) households there was at least one person with epilepsy. Only 1212 (46.9%) of 2583 people took ivermectin during the last distribution round in 2021. The annual epilepsy incidence was 77.3\/100,000 (95% CI: 9.4\u2013278.9\/100,000) and the annual epilepsy mortality was 251.2\/100,000 (95% CI: 133.8\u2013428.7\/100,000). In conclusion, a high prevalence and incidence of epilepsy was observed in villages in Mundri. Urgent action is needed to prevent children from developing onchocerciasis-associated epilepsy by strengthening the local onchocerciasis-elimination programme.<\/jats:p>","DOI":"10.3390\/pathogens11040396","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T23:31:43Z","timestamp":1648164703000},"page":"396","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Prevalence of Onchocerciasis-Associated Epilepsy in Mundri West and East Counties, South Sudan: A Door-to-Door Survey"],"prefix":"10.3390","volume":"11","author":[{"given":"Stephen Raimon","family":"Jada","sequence":"first","affiliation":[{"name":"Amref Health Africa, Juba P.O. Box 410, South Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-880X","authenticated-orcid":false,"given":"Alfred","family":"Dusabimana","sequence":"additional","affiliation":[{"name":"Global Health Institute, University of Antwerp, 2016 Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gasim","family":"Abd-Elfarag","sequence":"additional","affiliation":[{"name":"Amsterdam Center for Global Health, Department of Paediatrics and Department of Global Health, Amsterdam UMC, 1105 AZ Amsterdam, The Netherlands"},{"name":"Amsterdam Institute for Global Health and Development, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Okaro","sequence":"additional","affiliation":[{"name":"Amref Health Africa, Juba P.O. Box 410, South Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nele","family":"Brusselaers","sequence":"additional","affiliation":[{"name":"Global Health Institute, University of Antwerp, 2016 Antwerp, Belgium"},{"name":"Centre for Translational Microbiome Research, Karolinska Institutet, 17177 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4671-3519","authenticated-orcid":false,"given":"Jane Y.","family":"Carter","sequence":"additional","affiliation":[{"name":"Amref Health Africa Headquarters, Nairobi P.O. Box 30125, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoy Yibi","family":"Logora","sequence":"additional","affiliation":[{"name":"Neglected Tropical Diseases Unit, Ministry of Health, Juba P.O. 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