{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:43:45Z","timestamp":1791251025090,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>More than one million cases of leptospirosis occur across the globe annually, resulting in about 59,000 deaths. Dogs are one of the most important reservoirs of Leptospira species and play an important role in transmitting the pathogen to humans. Many of these infections are controlled by routine vaccination that has reduced the possible reintroduction of leptospiral serovars into the human population. However, it is still not clear how a vaccinated dog can become infected with one or more Leptospira serovars contained in the vaccine formulation and thus against which it should be immunized. Here, we present the case of an asymptomatic dog who developed leptospiral infection despite being vaccinated. This unusual case emphasizes the substantial impact of immunization on mitigating the acute signs of the disease, even while providing limited protection against infection. Further studies will be required to better understand the role of dogs in the environmental circulation of leptospiral serovars in Sardinia. Asymptomatic leptospiral infection in vaccinated dogs should be considered to allow for better diagnosis and management of the infection. This will be essential for preventing Leptospira outbreaks in the future.<\/jats:p>","DOI":"10.3390\/pathogens11040406","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:29:36Z","timestamp":1648416576000},"page":"406","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Isolation of Leptospira interrogans Serovar Canicola in a Vaccinated Dog without Clinical Symptoms"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2878-4682","authenticated-orcid":false,"given":"Ivana","family":"Piredda","sequence":"first","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale \u201cG. Pegreffi\u201d della Sardegna, Via Duca degli Abruzzi 8, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sechi","sequence":"additional","affiliation":[{"name":"Teaching Veterinary Hospital, University of Sassari, Via Vienna 2, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Cocco","sequence":"additional","affiliation":[{"name":"Teaching Veterinary Hospital, University of Sassari, Via Vienna 2, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-7680","authenticated-orcid":false,"given":"Loris","family":"Bertoldi","sequence":"additional","affiliation":[{"name":"BMR Genomics s.r.l., Via Redipuglia 22, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Palmas","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale \u201cG. Pegreffi\u201d della Sardegna, Via Duca degli Abruzzi 8, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-0463","authenticated-orcid":false,"given":"Valentina","family":"Chisu","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale \u201cG. Pegreffi\u201d della Sardegna, Via Duca degli Abruzzi 8, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1136\/vr.c4965","article-title":"Control of canine leptospirosis in Europe: Time for a change?","volume":"167","author":"Ellis","year":"2010","journal-title":"Vet. 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