{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:58:54Z","timestamp":1790506734850,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fontana Foundation","award":["no specific grant number"],"award-info":[{"award-number":["no specific grant number"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Objectives: Since the change in the millennium, an increase in cases of alveolar echinococcosis (AE) has been observed in endemic European countries. Previous studies indicate that a significant proportion of the new AE cases have an immunosuppression-associated condition (IAC). The aim of the current study was to determine how IACs impact the number of new AE diagnoses per year and the characteristics of AE at diagnosis and its clinical course at our center. Methods: Retrospective analysis of 189 patients with AE diagnosed between 2000 and 2021 and participating in the Zurich Echinococcosis Cohort Study (ZECS) included clinical characteristics of AE at diagnosis and report of an IAC, as well as the clinical course during follow-up. Results: Of 189 patients participating in this study, 38 had an IAC reported at, or shortly after, AE diagnosis. Over time, there was a steeper increase in the number of newly diagnosed AE patients without an IAC than the number of patients with IAC. Patients with an IAC were older at diagnosis, more frequently had an incidental finding of AE, smaller mean lesion size, and negative Em18 serology. All but two showed favorable outcomes on the last follow-up. Conclusion: IACs have little impact on the increase in new AE cases, as well as on the extent of the disease at diagnosis and clinical course.<\/jats:p>","DOI":"10.3390\/pathogens11040441","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T21:08:22Z","timestamp":1649365702000},"page":"441","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Characteristics and Clinical Course of Alveolar Echinococcosis in Patients with Immunosuppression-Associated Conditions: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6208-9694","authenticated-orcid":false,"given":"Ansgar","family":"Deibel","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordula","family":"Meyer zu Schwabedissen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Husmann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Grimm","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Vetsuisse and Medical Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Deplazes","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Vetsuisse and Medical Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5866-5182","authenticated-orcid":false,"given":"C\u00e4cilia S.","family":"Reiner","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-8192","authenticated-orcid":false,"given":"Beat","family":"M\u00fcllhaupt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1128\/CMR.17.1.107-135.2004","article-title":"Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern","volume":"17","author":"Eckert","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0889-8553(05)70268-5","article-title":"Cestodes. Echinococcus","volume":"25","author":"Ammann","year":"1996","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/bs.apar.2016.09.006","article-title":"The Echinococcoses: Diagnosis, Clinical Management and Burden of Disease","volume":"96","author":"Kern","year":"2017","journal-title":"Adv. Parasitol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/bjs.4998","article-title":"Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis","volume":"92","author":"Kadry","year":"2005","journal-title":"Br. J. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","article-title":"Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans","volume":"114","author":"Brunetti","year":"2010","journal-title":"Acta Trop."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jhep.2008.03.023","article-title":"Alveolar echinococcosis: From a deadly disease to a well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35 years","volume":"49","author":"Torgerson","year":"2008","journal-title":"J. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3201\/eid1306.061074","article-title":"Human alveolar echinococcosis after fox population increase, Switzerland","volume":"13","author":"Schweiger","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/cid\/ciu520","article-title":"Increased incidence and characteristics of alveolar echinococcosis in patients with immunosuppression-associated conditions","volume":"59","author":"Chauchet","year":"2014","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s15010-020-01479-4","article-title":"Spatial distribution and incidence trend of human alveolar echinococcosis in southwest Germany: Increased incidence and urbanization of the disease?","volume":"48","author":"Mueller","year":"2020","journal-title":"Infection"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e00060","DOI":"10.1016\/j.fawpar.2019.e00060","article-title":"Elevated incidence of alveolar echinococcosis in immunocompromised patients","volume":"16","author":"Lachenmayer","year":"2019","journal-title":"Food Waterborne Parasitol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/QCO.0000000000000765","article-title":"Alveolar echinococcosis: What triggers emergence in North America, Central Europe and Asia?","volume":"34","author":"Gottstein","year":"2021","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1055\/s-0041-1730925","article-title":"Hepatic Alveolar Echinococcosis","volume":"41","author":"Spahr","year":"2021","journal-title":"Semin. Liver Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pt.2003.11.011","article-title":"Wilderness in the city: The urbanization of Echinococcus multilocularis","volume":"20","author":"Deplazes","year":"2004","journal-title":"Trends Parasitol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1079\/JOH2006347","article-title":"Echinococcus multilocularis--a zoonosis of anthropogenic environments?","volume":"80","author":"Romig","year":"2006","journal-title":"J. Helminthol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.apar.2016.09.005","article-title":"Immunology of Alveolar and Cystic Echinococcosis (AE and CE)","volume":"96","author":"Gottstein","year":"2017","journal-title":"Adv. Parasitol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.trstmh.2005.04.020","article-title":"Brain metastasis of alveolar echinococcosis in a hyperendemic focus of Echinococcus multilocularis infection","volume":"99","author":"Yang","year":"2005","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0022-3476(97)70364-0","article-title":"Alveolar echinococcosis of the liver in a six-year-old girl with acquired immunodeficiency syndrome","volume":"130","author":"Sailer","year":"1997","journal-title":"J. Pediatri."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/hep.510300426","article-title":"Primary disease recurrence after liver transplantation for alveolar echinococcosis: Long-term evaluation in 15 patients","volume":"30","author":"Koch","year":"1999","journal-title":"Hepatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1017\/S0031182016000809","article-title":"Successful intestinal Echinococcus multilocularis oncosphere invasion and subsequent hepatic metacestode establishment in resistant RccHan\u2122: WIST rats after pharmacological immunosuppression","volume":"143","author":"Joekel","year":"2016","journal-title":"Parasitology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1017\/S0031182020002012","article-title":"Agranulocytosis leads to intestinal Echinococcus multilocularis oncosphere invasion and hepatic metacestode development in naturally resistant Wistar rats","volume":"148","author":"Joekel","year":"2021","journal-title":"Parasitology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"iv329","DOI":"10.1093\/annonc\/mdh947","article-title":"Opportunistic infections in patients with cancer","volume":"15","author":"Klastersky","year":"2004","journal-title":"Ann. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s13075-019-1997-5","article-title":"Comparing the burdens of opportunistic infections among patients with systemic rheumatic diseases: A nationally representative cohort study","volume":"21","author":"Hsu","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/acr.24348","article-title":"Epidemiology, Time Trends, and Outcomes of Serious Infections in Patients With Vasculitis: A Nineteen-Year National Study","volume":"73","author":"Singh","year":"2021","journal-title":"Arthritis Care Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.ackd.2019.01.004","article-title":"Immune Dysfunction and Risk of Infection in Chronic Kidney Disease","volume":"26","author":"Narayanan","year":"2019","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"546.e1","DOI":"10.1016\/j.cmi.2017.08.001","article-title":"A prospective multicentre study of the epidemiology and outcomes of bloodstream infection in cirrhotic patients","volume":"24","author":"Bartoletti","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2337\/dc17-2131","article-title":"Risk of Infection in Type 1 and Type 2 Diabetes Compared With the General Population: A Matched Cohort Study","volume":"41","author":"Carey","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/hiv.12609","article-title":"Secular trends in opportunistic infections, cancers and mortality in patients with AIDS during the era of modern combination antiretroviral therapy","volume":"19","author":"Sezgin","year":"2018","journal-title":"HIV Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e12691","DOI":"10.1111\/tid.12691","article-title":"A retrospective study to describe the epidemiology and outcomes of opportunistic infections after abdominal organ transplantation","volume":"19","author":"Helfrich","year":"2017","journal-title":"Transpl. Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S283","DOI":"10.1016\/j.parint.2005.11.041","article-title":"WHO classification of alveolar echinococcosis: Principles and application","volume":"55","author":"Kern","year":"2006","journal-title":"Parasitol. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s15010-011-0205-6","article-title":"Serological diagnosis of echinococcosis: The diagnostic potential of native antigens","volume":"40","author":"Schweiger","year":"2012","journal-title":"Infection"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jhep.2004.06.015","article-title":"Immunosurveillance of alveolar echinococcosis by specific humoral and cellular immune tests: Long-term analysis of the Swiss chemotherapy trial (1976\u20132001)","volume":"41","author":"Ammann","year":"2004","journal-title":"J. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ammann, R.W., Stumpe, K.D., Grimm, F., Deplazes, P., Huber, S., Bertogg, K., Fischer, D.R., and Mullhaupt, B. (2015). Outcome after Discontinuing Long-Term Benzimidazole Treatment in 11 Patients with Non-resectable Alveolar Echinococcosis with Negative FDG-PET\/CT and Anti-EmII\/3-10 Serology. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003964"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Deibel, A., Stocker, D., Meyer Zu Schwabedissen, C., Husmann, L., Kronenberg, P.A., Grimm, F., Deplazes, P., Reiner, C.S., and M\u00fcllhaupt, B. (2022). Evaluation of a structured treatment discontinuation in patients with inoperable alveolar echinococcosis on long-term benzimidazole therapy: A retrospective cohort study. PLoS Negl. Trop. Dis., 16.","DOI":"10.1371\/journal.pntd.0010146"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Hotz, J.F., Peters, L., Kapp-Schw\u00f6rer, S., Theis, F., Eberhardt, N., Essig, A., Gr\u00fcner, B., and Hagemann, J.B. (2022). Evaluation of Serological Markers in Alveolar Echinococcosis Emphasizing the Correlation of PET-CTI Tracer Uptake with RecEm18 and Echinococcus-Specific IgG. Pathogens, 11.","DOI":"10.3390\/pathogens11020239"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3201\/eid2406.161641","article-title":"Intense Focus of Alveolar Echinococcosis, South Kyrgyzstan","volume":"24","author":"Bebezov","year":"2018","journal-title":"Emerg. Infect. Dis."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/4\/441\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:49:15Z","timestamp":1760136555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/4\/441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["pathogens11040441"],"URL":"https:\/\/doi.org\/10.3390\/pathogens11040441","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,6]]}}}