{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:10:41Z","timestamp":1770819041520,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Fund through Operational Program Science and Education for Smart Growth 2014\u20132020","award":["BG05M2OP001\u20101.002\u20100001\u2010C04"],"award-info":[{"award-number":["BG05M2OP001\u20101.002\u20100001\u2010C04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Primate erythroparvovirus 1, commonly referred to as Parvovirus B19 (B19V), is a DNA virus that normally results in a mild childhood infection called \u201cerythema infectiosum\u201d. Besides respiratory spread, B19V can also be transmitted through transfusions, which may result in persistent anemia in immunodeficient hosts. Dialysis patients often face acute or chronic anemia after infection with B19V. Here, we describe the laboratory investigation of 21 patients with hematological disorders for B19V infections. B19V DNA was detected in 13 (62%) of them, with specific IgM antibodies in three of the DNA positives. All 13 patients received treatment and were laboratory-monitored over a period of one year. In only two patients (a 14-year-old child with a kidney transplantation and a 39-year-old patient with aplastic anemia), markers of recent B19V infection were still detectable in follow-up samples. For four B19V DNA positive samples, short sequences could be obtained, which clustered with genotype 1a reference strains. Our findings suggest that all cases of hematological disorders should be examined for specific B19V antibodies and DNA for accurate diagnosis and appropriate patient management.<\/jats:p>","DOI":"10.3390\/pathogens11050497","type":"journal-article","created":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:45:21Z","timestamp":1650761121000},"page":"497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Primate Erythroparvovirus 1 Infection in Patients with Hematological Disorders"],"prefix":"10.3390","volume":"11","author":[{"given":"Stefka","family":"Krumova","sequence":"first","affiliation":[{"name":"National Reference Laboratory \u201cMeasles, Mumps, Rubella\u201d, Department of Virology, National Center of Infectious and Parasitic Diseases, 1233 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivona","family":"Andonova","sequence":"additional","affiliation":[{"name":"National Reference Laboratory \u201cMeasles, Mumps, Rubella\u201d, Department of Virology, National Center of Infectious and Parasitic Diseases, 1233 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radostina","family":"Stefanova","sequence":"additional","affiliation":[{"name":"National Reference Laboratory \u201cMeasles, Mumps, Rubella\u201d, Department of Virology, National Center of Infectious and Parasitic Diseases, 1233 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polina","family":"Miteva","sequence":"additional","affiliation":[{"name":"Specialized Hospital for Active Treatment of Children\u2019s Diseases \u201cProf. Dr. Ivan Mitev\u201d EAD, 1612 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina","family":"Nenkova","sequence":"additional","affiliation":[{"name":"Department of Biology, Medical University, 9002 Varna, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5001-2128","authenticated-orcid":false,"given":"Judith M.","family":"H\u00fcbschen","sequence":"additional","affiliation":[{"name":"Clinical and Applied Virology Group, Department of Infection and Immunity, Luxembourg Institute of Health, 4354 Esch-sur-Alzette, Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"ref_1","first-page":"71","article-title":"Variants of B19","volume":"118","author":"Brown","year":"2004","journal-title":"Dev. 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