{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:21:28Z","timestamp":1781760088653,"version":"3.54.5"},"reference-count":12,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Background: Corneal infection of Colletotrichum gloeosporioides is uncommon and usually limited to the anterior stroma. However, we observed a case of corneal stromal perforation caused by this fungus under a compromised condition. Case: A 73-year-old woman consulted us with a severe corneal ulceration. She was a tangerine orange farmer who suffered from rheumatoid arthritis for more than ten years. Before consultation with us, she received pterygium excision in her right eye. She then developed a corneal ulceration and received topical glucocorticoid therapy upon diagnosis of rheumatoid arthritis-related stromal ulcer in the eye. At the first consultation with us, a corneal ulceration was observed in the inferotemporal area of her right cornea. Biological examination detected a filamentous fungus, Colletotrichum gloeosporioides. Topical and systemic antifungal treatments were not significantly effective. Fourteen days after consultation, the lesion grew worse, leading to stromal perforation, which was treated by therapeutic penetrating keratoplasty using a preserved corneal button. Conclusions: Topical glucocorticoid could accelerate the growth of Colletotrichum gloeosporioides before diagnosis, even though the primary cause of corneal ulceration development might be rheumatoid arthritis.<\/jats:p>","DOI":"10.3390\/pathogens11050526","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T07:08:58Z","timestamp":1651475338000},"page":"526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic Penetrating Keratoplasty in a Case of Corneal Perforation Caused by Colletotrichum gloeosporioides Infection"],"prefix":"10.3390","volume":"11","author":[{"given":"Kazuki","family":"Imai","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Sumioka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Iwanishi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihisa","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9862-3051","authenticated-orcid":false,"given":"Shin\u2019ichi","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuya","family":"Saika","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1067\/mjd.2000.113691","article-title":"Colletotrichum species as emerging opportunistic fungal pathogens: A report of 3 cases of phaeohyphomycosis and review","volume":"45","author":"Hoffmann","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1128\/JCM.42.6.2450-2454.2004","article-title":"Molecular and morphological identification of Colletotrichum species of clinical interest","volume":"42","author":"Cano","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1089\/jop.2011.0011","article-title":"Clinical characteristics of keratitis due to Colletotrichum gloeosporioides","volume":"27","author":"Shiraishi","year":"2011","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1128\/JCM.00151-11","article-title":"Colletotrichum truncatum: An unusual pathogen causing mycotic keratitis and endophthalmitis","volume":"49","author":"Shivaprakash","year":"2011","journal-title":"J. Clin. 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Ophthalmol."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/5\/526\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:04:14Z","timestamp":1760137454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/5\/526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,29]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["pathogens11050526"],"URL":"https:\/\/doi.org\/10.3390\/pathogens11050526","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,29]]}}}