{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:02:01Z","timestamp":1790744521974,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Scientific Research Deanship at University of Ha\u2019il- Saudi Arabia","award":["MDR-22 002"],"award-info":[{"award-number":["MDR-22 002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Blood plays a major role in transmitting infectious diseases such as hepatitis C virus (HCV), human immunodeficiency virus (HIV), hepatitis B virus (HBV), syphilis, malaria, and many others. Thus, this study sought to evaluate the distribution of HCV, HIV, syphilis, and malaria among blood donors in Yemen. This is a cross-sectional study, conducted on blood donors at the national center in Yemen. Blood donors\u2019 specimens were serologically tested for the presence of anti-HCV and anti-HIV antibodies, as well as anti-Treponema pallidum, anti-Plasmodium falciparum, and anti-Plasmodium vivax. A total of 16,367 donors were included in this study. Based on the donor\u2019s occupation, the study showed that the relative seroprevalence of anti-HCV Ab among the donors was statistically significant, and relatively high prevalence was found among military donors (2.8%). Positive HIV antibody tests were only reported in 33 male donors (0.2%), who were mostly manual workers. A remarkably high prevalence of anti-Treponema pallidum was observed among manual workers (3.1%). There was a statistically significant difference in the distribution of anti-malaria Ab based on residency and age groups. This study revealed that the prevalence of HCV, HIV, syphilis, and malaria among donors was 2.0%, 0.2%, 2.4%, and 0.7%, respectively. Further genotyping studies are necessary to provide a complete picture of the prevalence of transfusion-transmitted infections (TTIs).<\/jats:p>","DOI":"10.3390\/pathogens11070726","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T21:01:41Z","timestamp":1656277301000},"page":"726","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Prevalence of Transfusion-Transmitted Infections (HCV, HIV, Syphilis and Malaria) in Blood Donors: A Large-Scale Cross-Sectional Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3371-0477","authenticated-orcid":false,"given":"Talal","family":"Alharazi","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science, College of Applied Medical Sciences, University of Ha\u2019il, Hail 55476, Saudi Arabia"},{"name":"Department of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Taiz University, Taiz P.O. Box 6803, Yemen"},{"name":"Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha\u2019il, Hail 55476, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawfique K.","family":"Alzubiery","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory, Faculty of Medical and Health Sciences, Taiz University Al-Turbah Branch, Al-Turbah P.O. Box 6803, Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerold C.","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, College of Applied Medical Sciences, University of Ha\u2019il, Hail 55476, Saudi Arabia"},{"name":"Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha\u2019il, Hail 55476, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3068-0313","authenticated-orcid":false,"given":"Husam","family":"Qanash","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, College of Applied Medical Sciences, University of Ha\u2019il, Hail 55476, Saudi Arabia"},{"name":"Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha\u2019il, Hail 55476, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5884-0278","authenticated-orcid":false,"given":"Abdulrahman S.","family":"Bazaid","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, College of Applied Medical Sciences, University of Ha\u2019il, Hail 55476, Saudi Arabia"},{"name":"Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha\u2019il, Hail 55476, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3394-0686","authenticated-orcid":false,"given":"Malik A.","family":"Altayar","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdu","family":"Aldarhami","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Qunfudah Faculty of Medicine, Umm Al-Qura University, Al-Qunfudah 21961, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mohammed, Y., and Bekele, A. 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