{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:18:11Z","timestamp":1790381891895,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20190883"],"award-info":[{"award-number":["BK20190883"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["19KJB230007"],"award-info":[{"award-number":["19KJB230007"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BRA2020002"],"award-info":[{"award-number":["BRA2020002"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX21_3267"],"award-info":[{"award-number":["KYCX21_3267"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["BK20190883"],"award-info":[{"award-number":["BK20190883"]}]},{"name":"The Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["19KJB230007"],"award-info":[{"award-number":["19KJB230007"]}]},{"name":"The Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["BRA2020002"],"award-info":[{"award-number":["BRA2020002"]}]},{"name":"The Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["KYCX21_3267"],"award-info":[{"award-number":["KYCX21_3267"]}]},{"name":"fifth phase of the \u201c333 project\u201d scientific research project in Jiangsu Province","award":["BK20190883"],"award-info":[{"award-number":["BK20190883"]}]},{"name":"fifth phase of the \u201c333 project\u201d scientific research project in Jiangsu Province","award":["19KJB230007"],"award-info":[{"award-number":["19KJB230007"]}]},{"name":"fifth phase of the \u201c333 project\u201d scientific research project in Jiangsu Province","award":["BRA2020002"],"award-info":[{"award-number":["BRA2020002"]}]},{"name":"fifth phase of the \u201c333 project\u201d scientific research project in Jiangsu Province","award":["KYCX21_3267"],"award-info":[{"award-number":["KYCX21_3267"]}]},{"name":"Postgraduate Research &amp; Practice Innovation Program of Jiangsu Province","award":["BK20190883"],"award-info":[{"award-number":["BK20190883"]}]},{"name":"Postgraduate Research &amp; Practice Innovation Program of Jiangsu Province","award":["19KJB230007"],"award-info":[{"award-number":["19KJB230007"]}]},{"name":"Postgraduate Research &amp; Practice Innovation Program of Jiangsu Province","award":["BRA2020002"],"award-info":[{"award-number":["BRA2020002"]}]},{"name":"Postgraduate Research &amp; Practice Innovation Program of Jiangsu Province","award":["KYCX21_3267"],"award-info":[{"award-number":["KYCX21_3267"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD)","award":["BK20190883"],"award-info":[{"award-number":["BK20190883"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD)","award":["19KJB230007"],"award-info":[{"award-number":["19KJB230007"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD)","award":["BRA2020002"],"award-info":[{"award-number":["BRA2020002"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD)","award":["KYCX21_3267"],"award-info":[{"award-number":["KYCX21_3267"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Intestinal infections caused by methicillin-sensitive Staphylococcus aureus (MSSA) have posed a great challenge for clinical treatments. In recent years, the intestinal carriage rates of MSSA have risen steadily in hospital settings in China. However, the epidemiology and molecular characteristics of MSSA from the intestinal tracts of Chinese adult patients remain unknown. In the present study, a total of 80 S. aureus isolates, including 64 MSSA and 16 methicillin-resistant Staphylococcus aureus (MRSA), were recovered from 466 fecal swabs in adult patients between 2019 and 2021 in China. The MSSA isolates exhibited high resistance to penicillin (92.2%) and erythromycin (45.3%). In addition, a higher proportion of MSSA isolates (14.1%) were multidrug-resistant (MDR) strains than that of MRSA isolates (1.3%). Among the 64 MSSA isolates, we identified 17 MLST types, of which ST398 and ST15 were the most predominant types. The most frequently detected resistance genes were blaZ (87.5%) and erm(C) (21.9%). The hemolysin genes (hla, hld, hlgA, hlgB, hlgC) were detected in all the MSSA isolates, but the Panton\u2013Valentine leucocidin (pvl) gene was identified in 1.7% of the MSSA isolates. Our findings indicated that the prevalence and antimicrobial resistance of intestinal MSSA was a serious concern among adult patients in China.<\/jats:p>","DOI":"10.3390\/pathogens11090978","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T22:53:42Z","timestamp":1661813622000},"page":"978","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Molecular Characterization of Methicillin-Sensitive Staphylococcus aureus from the Intestinal Tracts of Adult Patients in China"],"prefix":"10.3390","volume":"11","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"Jiangsu Key Lab of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225000, China"},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-Food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-2744","authenticated-orcid":false,"given":"Yuanyue","family":"Tang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Lab of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225000, China"},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-Food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou 225000, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Lab of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225000, China"},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-Food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Lab of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225000, China"},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-Food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0923-9758","authenticated-orcid":false,"given":"Qiuchun","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Lab of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225000, China"},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-Food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou 225000, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2214-3358","authenticated-orcid":false,"given":"Xinan","family":"Jiao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Lab of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225000, China"},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-Food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou 225000, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. 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