{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:37:45Z","timestamp":1784687865461,"version":"3.55.0"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000053"],"award-info":[{"award-number":["32000053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Q20202603"],"award-info":[{"award-number":["Q20202603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020ZD09"],"award-info":[{"award-number":["2020ZD09"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020KF004"],"award-info":[{"award-number":["2020KF004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Provincial Education Department","award":["32000053"],"award-info":[{"award-number":["32000053"]}]},{"name":"Provincial Education Department","award":["Q20202603"],"award-info":[{"award-number":["Q20202603"]}]},{"name":"Provincial Education Department","award":["2020ZD09"],"award-info":[{"award-number":["2020ZD09"]}]},{"name":"Provincial Education Department","award":["2020KF004"],"award-info":[{"award-number":["2020KF004"]}]},{"name":"Science and Technology Plan (in the field of Medical and health care) of Xiangyang","award":["32000053"],"award-info":[{"award-number":["32000053"]}]},{"name":"Science and Technology Plan (in the field of Medical and health care) of Xiangyang","award":["Q20202603"],"award-info":[{"award-number":["Q20202603"]}]},{"name":"Science and Technology Plan (in the field of Medical and health care) of Xiangyang","award":["2020ZD09"],"award-info":[{"award-number":["2020ZD09"]}]},{"name":"Science and Technology Plan (in the field of Medical and health care) of Xiangyang","award":["2020KF004"],"award-info":[{"award-number":["2020KF004"]}]},{"name":"State Key Laboratory of Virology of China","award":["32000053"],"award-info":[{"award-number":["32000053"]}]},{"name":"State Key Laboratory of Virology of China","award":["Q20202603"],"award-info":[{"award-number":["Q20202603"]}]},{"name":"State Key Laboratory of Virology of China","award":["2020ZD09"],"award-info":[{"award-number":["2020ZD09"]}]},{"name":"State Key Laboratory of Virology of China","award":["2020KF004"],"award-info":[{"award-number":["2020KF004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Corynebacterium striatum has developed into a new community-acquired and hospital-acquired multi-drug resistance (MDR) bacterium, and is a potential target pathogen for infection control and antibacterial management projects. In this study, non-duplicate samples of inpatients were collected from a local central hospital. Mass spectrometry showed that 54 C. striatum isolates mainly appeared in secretion and sputum from 14 departments. Protein fingerprint cluster analysis showed that the isolates were divided into four groups, most of which appeared in summer. The drug resistance test showed that all strains had multi-drug resistance, with high resistance rates to lincosamides, quinolones and tetracycline detected. Further analysis of the phylogenetic tree of C. striatum was conducted by cloning the 16S rRNA gene. It was found that isolates in the same department had high homology and tended to be located in the same branch or to be crossed in the same main branch. The strains in the same evolutionary branch group had the same drug resistance. Screening of site-specific recombinant elements revealed that 18 strains had integrase genes with the same sequence. This study shows that there may be mobile genetic elements in clinical isolates that drive gene exchange among strains, thus causing the cross-infection, spread and evolution of pathogenic bacteria in the hospital.<\/jats:p>","DOI":"10.3390\/pathogens11091012","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T01:51:57Z","timestamp":1662515517000},"page":"1012","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification and Evolutionary Relationship of Corynebacterium striatum Clinical Isolates"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-2796","authenticated-orcid":false,"given":"Jiao","family":"Wang","sequence":"first","affiliation":[{"name":"School of Basic Medicine, Hubei University of Arts and Science, Xiangyang 441053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Pei","sequence":"additional","affiliation":[{"name":"Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Hubei University of Arts and Science, Xiangyang 441053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Hubei University of Arts and Science, Xiangyang 441053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqiang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Hubei University of Arts and Science, Xiangyang 441053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Liao","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Hubei University of Arts and Science, Xiangyang 441053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liang","sequence":"additional","affiliation":[{"name":"Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104887","DOI":"10.1016\/j.micpath.2021.104887","article-title":"Virulence of clinically relevant multidrug resistant Corynebacterium striatum strains and their ability to adhere to human epithelial cells and inert surfaces","volume":"155","author":"Alibi","year":"2021","journal-title":"Microb. 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