{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:11:34Z","timestamp":1760231494207,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T00:00:00Z","timestamp":1663977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Viral infections can be a serious complication of therapy in children with acute lymphoblastic leukemia (ALL). In this study, we focused on the incidence and the profile of viral infection in children with ALL treated in 17 pediatric oncology centers in Poland in the two-year periods of 2018\u20132019 and 2020\u20132021. We also compared the frequency of viral infections in 2018\u20132019 to that in 2020\u20132021. In 2020\u20132021, a total of 192 children with ALL had a viral infection during intensive chemotherapy. A total number of 312 episodes of viral infections were diagnosed. The most common infections detected in the samples were: COVID-19 (23%), rhinovirus (18%), and respiratory syncytial virus (14%). COVID-19 and BK virus infections were the reason for the death 1% of all patients. In 2018\u20132019, a total of 53 ALL patients who had a viral infection were reported and 72 viral events were observed, mainly adenovirus (48.6%), rotavirus (31.9%), and herpes zoster (8.3%). No deaths were reported during this period. The cumulative incidence of viral infections in 2018\u20132019 was 10.4%, while for 2020\u20132021, it was 36.7%. In conclusion, a high incidence of COVID-19 infection was observed among pediatric patients with ALL in Poland. The mortality rate in our material was low. The viral profile in ALL children undergoing chemotherapy can be useful for clinicians to improve prophylactic and therapeutic strategies.<\/jats:p>","DOI":"10.3390\/pathogens11101091","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T03:34:17Z","timestamp":1664163257000},"page":"1091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Viral Infection Profile in Children Treated for Acute Lymphoblastic Leukemia\u2014Results of Nationwide Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7207-156X","authenticated-orcid":false,"given":"Joanna","family":"Zawitkowska","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology, Oncology and Transplantation, Medical University, 20-059 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7094-9129","authenticated-orcid":false,"given":"Katarzyna","family":"Drabko","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Oncology and Transplantation, Medical University, 20-059 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-7518","authenticated-orcid":false,"given":"Krzysztof","family":"Czy\u017cewski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Dziedzic","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5467-5914","authenticated-orcid":false,"given":"Kamila","family":"Jaremek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja","family":"Zalas-Wi\u0119cek","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Szmydki-Baran","sequence":"additional","affiliation":[{"name":"Department of Hematology and Pediatrics, Medical University of Warsaw, 02-091 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Hutnik","sequence":"additional","affiliation":[{"name":"Department of Hematology and Pediatrics, Medical University of Warsaw, 02-091 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Matysiak","sequence":"additional","affiliation":[{"name":"Department of Hematology and Pediatrics, Medical University of Warsaw, 02-091 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-7889","authenticated-orcid":false,"given":"Wojciech","family":"Czoga\u0142a","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, 31-008 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walentyna","family":"Balwierz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, 31-008 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0140-431X","authenticated-orcid":false,"given":"Iwona","family":"\u017bak","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Children\u2019s Hospital, Jagiellonian University Medical College, 31-008 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Salamonowicz-Bodzioch","sequence":"additional","affiliation":[{"name":"Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernarda","family":"Kazanowska","sequence":"additional","affiliation":[{"name":"Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gra\u017cyna","family":"Wr\u00f3bel","sequence":"additional","affiliation":[{"name":"Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-5799","authenticated-orcid":false,"given":"Krzysztof","family":"Ka\u0142wak","sequence":"additional","affiliation":[{"name":"Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Tomaszewska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology and Oncology, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5336-261X","authenticated-orcid":false,"given":"Tomasz","family":"Szczepa\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology and Oncology, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8836-8605","authenticated-orcid":false,"given":"Olga","family":"Zaj\u0105c-Spycha\u0142a","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Wachowiak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"P\u0142onowski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryna","family":"Krawczuk-Rybak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6976-8411","authenticated-orcid":false,"given":"Aleksandra","family":"Kr\u00f3lak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Ociepa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Urasi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Pierlejewski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oncology & Hematology, Medical University of Lodz, 90-647 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2714-5851","authenticated-orcid":false,"given":"Wojciech","family":"M\u0142ynarski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oncology & Hematology, Medical University of Lodz, 90-647 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Urba\u0144ska-Rakus","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Hematology and Oncology, City Hospital, 41-500 Chorzow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Machnik","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Hematology and Oncology, City Hospital, 41-500 Chorzow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Paj\u0105k","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Hematology and Oncology, City Hospital, 41-500 Chorzow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanda","family":"Badowska","sequence":"additional","affiliation":[{"name":"Clinical Department of Pediatric Oncology and Hematology, Department of Clinical Pediatrics, University of Warmia and Mazury in Olsztyn, Regional Specialized Children\u2019s Hospital in Olsztyn, 10-561 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Brzeski","sequence":"additional","affiliation":[{"name":"Clinical Department of Pediatric Oncology and Hematology, Department of Clinical Pediatrics, University of Warmia and Mazury in Olsztyn, Regional Specialized Children\u2019s Hospital in Olsztyn, 10-561 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Mycko","sequence":"additional","affiliation":[{"name":"Clinical Department of Pediatric Oncology and Hematology, Department of Clinical Pediatrics, University of Warmia and Mazury in Olsztyn, Regional Specialized Children\u2019s Hospital in Olsztyn, 10-561 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Ma\u0144ko-Gli\u0144ska","sequence":"additional","affiliation":[{"name":"Clinical Department of Pediatric Oncology and Hematology, Department of Clinical Pediatrics, University of Warmia and Mazury in Olsztyn, Regional Specialized Children\u2019s Hospital in Olsztyn, 10-561 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Urbanek-D\u0105dela","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology, Collegium Medium of Jan Kochanowski University in Kielce, 25-317 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gra\u017cyna","family":"Karolczyk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology, Collegium Medium of Jan Kochanowski University in Kielce, 25-317 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Mizia-Malarz","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children\u2019s Care Health, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weronika","family":"Stolpa","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children\u2019s Care Health, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Skowron-Kandzia","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children\u2019s Care Health, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Musia\u0142","sequence":"additional","affiliation":[{"name":"Clinic of Paediatric Oncology and Haematology, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-9142","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Chaber","sequence":"additional","affiliation":[{"name":"Clinic of Paediatric Oncology and Haematology, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninela","family":"Irga-Jaworska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Bie\u0144","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-119X","authenticated-orcid":false,"given":"Jan","family":"Styczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,24]]},"reference":[{"key":"ref_1","first-page":"300","article-title":"Progress in Treatment of Viral Infections in Children with Acute Lymphoblastic Leukemia","volume":"10","author":"Moschovi","year":"2016","journal-title":"Oncol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s13045-021-01181-4","article-title":"COVID-19 in pediatric cancer patients is associated with treatment interruptions but not with short-term mortality: A Polish national study","volume":"14","author":"Zakrzewska","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_3","unstructured":"(2020, September 02). Regulation of the Minister of Health, Available online: https:\/\/isap.sejm.gov.pl\/isap.nsf\/download.xsp\/WDU20200001506\/O\/D20201506.pdf."},{"key":"ref_4","unstructured":"(2021, May 16). Guidance for Discharge and Ending Isolation of People with COVID-19\u2014Second Update. Available online: https:\/\/www.ecdc.europa.eu\/sites\/default\/fles\/documents\/Guidance-for-discharge-and-ending-of-isolation-of-people-with-COVID-19.pdf."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/annonc\/mdw557","article-title":"Infection-related complications during treatment for childhood acute lymphoblastic leukemia","volume":"28","author":"Inaba","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_6","first-page":"555","article-title":"Profile of infections in Polish pediatric hematology, oncology and stem cell transplantation centers in 2014-2015","volume":"8","author":"Styczynski","year":"2016","journal-title":"Post. N. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2478\/ahp-2019-0027","article-title":"Infectious complications in children and adults with hematological malignancies","volume":"50","year":"2019","journal-title":"Acta Haematol. Pol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"179.e1","DOI":"10.1016\/j.cmi.2015.10.017","article-title":"Increased risk of infections and infection-related mortality in children undergoing haematopoietic stem cell transplantation compared to conventional anticancer therapy: A multicentre nationwide study","volume":"22","author":"Styczynski","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/s41375-022-01578-1","article-title":"Recommendations for the management of COVID-19 in patients with haematological malignancies or haematopoietic cell transplantation, from the 2021 European Conference on Infections in Leukaemia (ECIL 9)","volume":"36","author":"Cesaro","year":"2022","journal-title":"Leukemia"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2478\/ahp-2019-0026","article-title":"ABC of viral infections in hematology: Focus on herpesviruses","volume":"50","author":"Styczynski","year":"2019","journal-title":"Acta Haematol. Pol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jiac.2019.04.005","article-title":"Infectious profile in children with ALL during chemotherapy: A report of study group for infections","volume":"25","author":"Zawitkowska","year":"2019","journal-title":"J. Infect. Chemother."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1200\/JCO.19.01692","article-title":"Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16","volume":"37","author":"Jeha","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3389\/fped.2019.00368","article-title":"Molecular Approaches to Treating Pediatric Leukemias","volume":"7","author":"Kuhlen","year":"2019","journal-title":"Front. Pediatr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1200\/JCO.2011.37.8018","article-title":"Improved Survival for Children and Adolescents with Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children\u2019s Oncology Group","volume":"30","author":"Hunger","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1200\/JCO.2014.59.1636","article-title":"Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration","volume":"33","author":"Pui","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.12688\/f1000research.10768.1","article-title":"Noninfectious chemotherapy-associated acute toxicities during childhood acute lymphoblastic leukemia therapy","volume":"6","author":"Schmiegelow","year":"2017","journal-title":"F1000Research"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1182\/blood-2014-03-560847","article-title":"Infection-related mortality in children with acute lymphoblastic leukemia: An analysis of infectious deaths on UKALL2003","volume":"124","author":"Bate","year":"2014","journal-title":"Blood"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Inaba, H., and Pui, C.H. (2021). Advances in the Diagnosis and Treatment of Pediatric Acute Lymphoblastic Leukemia. J. Clin. Med., 10.","DOI":"10.3390\/jcm10091926"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00520-005-0884-6","article-title":"Infections in a pediatric patient cohort with acute lymphoblastic leukemia during the entire course of treatment","volume":"14","author":"Katsimpardi","year":"2006","journal-title":"Support. Care Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1590\/1806-9304202100s100017","article-title":"COVID-19 cohort on children with cancer: Delay in treatment and increased frequency of deaths","volume":"21","author":"Lima","year":"2021","journal-title":"Rev. Bras. Sa\u00fade Matern. Infant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e28397","DOI":"10.1002\/pbc.28397","article-title":"COVID-19 infection in children and adolescents with cancer in Madrid","volume":"67","author":"Rojas","year":"2020","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_22","unstructured":"Polish Ministry of Health (2021, September 27). Common Guidelines for Group 1B Patients and Healthcare Professionals on Vaccination against COVID-19. [Wsp\u00f3lne Wytyczne dla Pacjent\u00f3w z Grupy 1B i Personelu Medycznego w Zakresie Szczepienia Przeciwko COVID-19.], Available online: https:\/\/www.gov.pl\/web\/szczepimysie\/wspolne-wytyczne-dla-pacjentow-z-grupy-1b-i-personelu-medycznego-w-zakresie-szczepienia-przeciwko-covid-19."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/10\/1091\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:38:41Z","timestamp":1760143121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/10\/1091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,24]]},"references-count":22,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["pathogens11101091"],"URL":"https:\/\/doi.org\/10.3390\/pathogens11101091","relation":{},"ISSN":["2076-0817"],"issn-type":[{"type":"electronic","value":"2076-0817"}],"subject":[],"published":{"date-parts":[[2022,9,24]]}}}