{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:14:37Z","timestamp":1760231677398,"version":"build-2065373602"},"reference-count":12,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft"},{"name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Intestinal microbiota such as Fusobacterium nucleatum play an important role in the pathogenesis of colorectal cancer. Here, we describe the case of a 47-year-old patient presenting with endophthalmitis and a liver abscess due to Fusobacterium nucleatum that prompted the diagnosis of colorectal cancer as the most likely source of infection. This case highlights that colorectal cancer needs to be considered in patients with systemic infection with Fusobacterium nucleatum and colonoscopy should be performed.<\/jats:p>","DOI":"10.3390\/pathogens11101113","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:53:19Z","timestamp":1664405599000},"page":"1113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rectal Cancer Presenting with Absceding Infection Due to Fusobacterium nucleatum"],"prefix":"10.3390","volume":"11","author":[{"given":"Sebastian","family":"Zundler","sequence":"first","affiliation":[{"name":"Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mardin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0458-7075","authenticated-orcid":false,"given":"Simone","family":"Bertz","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Vitali","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Strau\u00df","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1746-6758","authenticated-orcid":false,"given":"Julia","family":"F\u00fcrst","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus F.","family":"Neurath","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deike","family":"Strobel","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0140-6736(05)17706-X","article-title":"Colorectal Cancer","volume":"365","author":"Weitz","year":"2005","journal-title":"Lancet Lond. Engl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41577-021-00534-x","article-title":"The Inflammatory Pathogenesis of Colorectal Cancer","volume":"21","author":"Schmitt","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1053\/j.gastro.2019.06.048","article-title":"Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer","volume":"158","author":"Song","year":"2020","journal-title":"Gastroenterology"},{"doi-asserted-by":"crossref","unstructured":"Yang, Y., Weng, W., Peng, J., Hong, L., Yang, L., Toiyama, Y., Gao, R., Liu, M., Yin, M., and Pan, C. (2017). Fusobacterium Nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-\u039aB, and Up-Regulating Expression of MicroRNA-21. Gastroenterology, 152.","key":"ref_4","DOI":"10.1053\/j.gastro.2016.11.018"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1980347","DOI":"10.1080\/19490976.2021.1980347","article-title":"Fusobacterium Nucleatum Promotes Colorectal Cancer Metastasis through MiR-1322\/CCL20 Axis and M2 Polarization","volume":"13","author":"Xu","year":"2021","journal-title":"Gut Microbes"},{"doi-asserted-by":"crossref","unstructured":"Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., and Nagarsheth, N. (2017). Fusobacterium Nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy. Cell, 170.","key":"ref_6","DOI":"10.1016\/j.cell.2017.07.008"},{"key":"ref_7","first-page":"859","article-title":"In Vitro Activity of Meropenem Compared with Imipenem, Metronidazole, Ampicillin, and Ampicillin\/Sulbactam against Anaerobes","volume":"44","author":"Schumacher","year":"1994","journal-title":"Arzneimittel-Forschung"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"710165","DOI":"10.3389\/fcell.2021.710165","article-title":"Fusobacterium Nucleatum Acts as a Pro-Carcinogenic Bacterium in Colorectal Cancer: From Association to Causality","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. 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Medicina, 58.","key":"ref_11","DOI":"10.3390\/medicina58040546"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.cmi.2018.05.016","article-title":"Impact of Antibiotic Administration on Blood Culture Positivity at the Beginning of Sepsis: A Prospective Clinical Cohort Study","volume":"25","author":"Scheer","year":"2018","journal-title":"Clin. Microbiol. 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