{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:30:28Z","timestamp":1765960228546,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603163"],"award-info":[{"award-number":["81603163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The incidence of hospital-acquired infections caused by Chryseobacterium indologenes (C. indologenes) is increasing. This study investigated the epidemiological and clinical features of C. indologenes intra-abdominal infections in patients who underwent orthotopic liver transplantation (OLT). In this retrospective study, 53 consecutive non-replicate clinical isolates of C. indologenes were collected and identified from the OLT patients at a tertiary care university hospital in Shanghai in 2017. Genetic relatedness of the isolates was determined by enterobacterial repetitive intergenic consensus polymerase chain reaction DNA fingerprinting. Antimicrobial susceptibility of the isolates was measured using the microdilution broth method. Nosocomial clonal transmission of C. indologenes was confirmed by bacterial homology analysis. All C. indologenes isolates were resistant to \u03b2-lactams, carbapenems, quinolones, and aminoglycosides, and showed susceptibility to trimethoprim\u2013sulfamethoxazole and minocycline. Multivariate risk modelling revealed that \u22652 bed transfers and an operation time of \u22658 h were independent risk factors for C. indologenes intra-abdominal infection after OLT. A nomogram was constructed based on the screened risk factors, which showed good concordance and accuracy. Clonal dissemination of C. indologenes in OLT patients was demonstrated and several risk factors for intra-abdominal infections were identified. Epidemiological surveillance of this organism and extensive surveillance programs are imperative worldwide.<\/jats:p>","DOI":"10.3390\/pathogens11101126","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:09:29Z","timestamp":1664492969000},"page":"1126","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Characteristics and Risk Factors for Intra-Abdominal Infection with Chryseobacterium indologenes after Orthotopic Liver Transplantation"],"prefix":"10.3390","volume":"11","author":[{"given":"Yixin","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China"},{"name":"Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission, Shanghai 200040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China"},{"name":"Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission, Shanghai 200040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China"},{"name":"Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission, Shanghai 200040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China"},{"name":"Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission, Shanghai 200040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/BF02447918","article-title":"Increasing incidence of nosocomial Chryseobacterium indologenes infections in Taiwan","volume":"16","author":"Hsueh","year":"1997","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis. Off. Publ. Eur. Soc. Clin. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1179\/1973947814Y.0000000206","article-title":"Transient bacteraemia due to Chryseobacterium indologenes in an immunocompetent patient: A case report and literature review","volume":"27","author":"Esposito","year":"2015","journal-title":"J. Chemother."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jmii.2012.08.007","article-title":"Clinical and epidemiological features of Chryseobacterium indologenes infections: Analysis of 215 cases","volume":"46","author":"Chen","year":"2013","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1017\/ice.2018.126","article-title":"A cluster of Chryseobacterium indologenes cases related to drainage water in intensive care units","volume":"39","author":"Cantero","year":"2018","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1056\/NEJMra064928","article-title":"Infection in solid-organ transplant recipients","volume":"357","author":"Fishman","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.3748\/wjg.v20.i20.6211","article-title":"Bacterial infection after liver transplantation","volume":"20","author":"Kim","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1002\/lt.22378","article-title":"Infections in immunocompromised hosts and organ transplant recipients: Essentials","volume":"17","author":"Fishman","year":"2011","journal-title":"Liver Transpl."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/lt.24486","article-title":"Multidrug-resistant organisms in liver transplant: Mitigating risk and managing infections","volume":"22","author":"Hand","year":"2016","journal-title":"Liver Transpl."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jhep.2018.10.027","article-title":"Multidrug-resistant bacterial infections in patients with decompensated cirrhosis and with acute-on-chronic liver failure in Europe","volume":"70","author":"Prado","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/cid\/ciy199","article-title":"Genomic Surveillance Reveals Diversity of Multidrug-Resistant Organism Colonization and Infection: A Prospective Cohort Study in Liver Transplant Recipients","volume":"67","author":"Macesic","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1399-3062.2011.00711.x","article-title":"Chryseobacterium indologenes subcutaneous port-related bacteremia in a liver transplant patient","volume":"14","author":"Shah","year":"2012","journal-title":"Transpl. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"668","DOI":"10.21037\/atm-21-933","article-title":"Clinical and molecular characteristics of Chryseobacterium indologenes isolates at a teaching hospital in Shanghai, China","volume":"9","author":"Zhang","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_13","unstructured":"Clinical and Laboratory Standards Institute (CLSI) (2019). Performance Standards for Antimicrobial Susceptibility Testing. 29th Informational Supplement, Clinical and Laboratory Standards Institute. Document M100."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1093\/nar\/19.24.6823","article-title":"Distribution of repetitive DNA sequences in eubacteria and application to fingerprinting of bacterial genomes","volume":"19","author":"Versalovic","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","article-title":"CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting","volume":"36","author":"Horan","year":"2008","journal-title":"Am. J. Infect. Control"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/hep.21563","article-title":"The model for end-stage liver disease (MELD)","volume":"45","author":"Kamath","year":"2007","journal-title":"Hepatology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1099\/13500872-142-5-1097","article-title":"Application of a suite of 16S rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment","volume":"142","author":"Manz","year":"1996","journal-title":"Microbiology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jmii.2014.04.004","article-title":"Identification, epidemiological relatedness, and biofilm formation of clinical Chryseobacterium indologenes isolates from central Taiwan","volume":"48","author":"Chang","year":"2015","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/tid.12400","article-title":"Chryseobacterium indologenes in four patients with leukemia","volume":"17","author":"Deng","year":"2015","journal-title":"Transpl. Infect. Dis. Off. J. Transplant. Soc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s15010-013-0479-y","article-title":"Chryseobacterium indologenes central nervous system infection in infancy: An emergent pathogen?","volume":"42","author":"Olbrich","year":"2014","journal-title":"Infection"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"bcr2013009410","DOI":"10.1136\/bcr-2013-009410","article-title":"Chryseobacterium indologenes peritonitis in peritoneal dialysis","volume":"2013","author":"Afshar","year":"2013","journal-title":"BMJ Case Rep."},{"key":"ref_22","first-page":"312","article-title":"Is Chryseobacterium indologenes a shunt-lover bacterium? A case report and review of the literature","volume":"21","author":"Ozcan","year":"2013","journal-title":"Infez. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bpg.2012.01.004","article-title":"Risk factors for infection after liver transplantation","volume":"26","author":"Verspaget","year":"2012","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.3748\/wjg.v20.i20.6201","article-title":"Multidrug-resistant bacterial infections after liver transplantation: An ever-growing challenge","volume":"20","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.3748\/wjg.v24.i38.4311","article-title":"Management of bacterial and fungal infections in end stage liver disease and liver transplantation: Current options and future directions","volume":"24","author":"Righi","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.2147\/IDR.S177247","article-title":"Health care-associated infections\u2014An overview","volume":"11","author":"Haque","year":"2018","journal-title":"Infect. Drug. Resist."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/bmjqs-2020-012124","article-title":"Association between intrahospital transfer and hospital-acquired infection in the elderly: A retrospective case-control study in a UK hospital network","volume":"30","author":"Boncea","year":"2021","journal-title":"BMJ Qual. Saf."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ajic.2009.08.016","article-title":"Exposure to hospital roommates as a risk factor for health care-associated infection","volume":"38","author":"Hamel","year":"2010","journal-title":"Am. J. Infect. Control"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1089\/sur.2017.089","article-title":"Prolonged Operative Duration Increases Risk of Surgical Site Infections: A Systematic Review","volume":"18","author":"Cheng","year":"2017","journal-title":"Surg. Infect."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7036","DOI":"10.3748\/wjg.v21.i22.7036","article-title":"Sequential vs simultaneous revascularization in patients undergoing liver transplantation: A meta-analysis","volume":"21","author":"Wang","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/SLA.0b013e3182602bb7","article-title":"Effect of immediate reconstruction on postmastectomy surgical site infection","volume":"256","author":"Nguyen","year":"2012","journal-title":"Ann. Surg."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/10\/1126\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:42:07Z","timestamp":1760143327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/10\/1126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":31,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["pathogens11101126"],"URL":"https:\/\/doi.org\/10.3390\/pathogens11101126","relation":{},"ISSN":["2076-0817"],"issn-type":[{"type":"electronic","value":"2076-0817"}],"subject":[],"published":{"date-parts":[[2022,9,29]]}}}