{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:48:49Z","timestamp":1793213329816,"version":"4.5.0"},"reference-count":121,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"},{"name":"Academy of Sciences for the Developing World (TWAS)"},{"name":"Oswaldo Cruz Institute, Oswaldo Cruz Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Growth factors (GFs) have a role in tissue repair and in the modulation of the expression of inflammatory cells in damage caused by pathogens. This study aims to systematize the evidence on the role of GFs in the pathogenesis of dengue. This scoping review considered all published peer-reviewed studies in the MEDLINE and Embase databases. Ultimately, 58 studies that analyzed GFs in dengue patients, published between 1998 and 2021, were included. DENV-2 infection and secondary infection were more frequent in the patients studied. ELISA and multiplex immunoassay (Luminex) were the most used measurement techniques. Increased levels of vascular endothelial growth factor, granulocyte\u2013macrophage colony-stimulating factor, granulocyte colony-stimulating factor, transforming growth factor beta, and hepatocyte growth factor as well as reduced levels of platelet-derived growth factor and epidermal growth factor were observed in severe dengue in most studies. Vascular endothelial growth factor and hepatocyte growth factor were identified as biomarkers of severity. In addition, there is evidence that the dengue virus can use the growth factor pathway to facilitate its entry into the cell and promote its viral replication. The use of tyrosine kinase inhibitors is an alternative treatment for dengue that is being studied.<\/jats:p>","DOI":"10.3390\/pathogens11101179","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T22:21:11Z","timestamp":1665699671000},"page":"1179","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Role of Growth Factors in the Pathogenesis of Dengue: A Scoping Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-3542","authenticated-orcid":false,"given":"Victor Edgar","family":"Fiestas Sol\u00f3rzano","sequence":"first","affiliation":[{"name":"Viral Immunology Laboratory, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Curtinhas","family":"de Lima","sequence":"additional","affiliation":[{"name":"Viral Immunology Laboratory, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzinandes Leal","family":"de Azeredo","sequence":"additional","affiliation":[{"name":"Viral Immunology Laboratory, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2022, March 12). Dengue and Severe Dengue Geneva. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/imm.12748","article-title":"Pathogenesis of vascular leak in dengue virus infection","volume":"151","author":"Malavige","year":"2017","journal-title":"Immunology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00284-020-02284-w","article-title":"Current Understanding of the Pathogenesis of Dengue Virus Infection","volume":"78","author":"Bhatt","year":"2021","journal-title":"Curr. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e3589","DOI":"10.7717\/peerj.3589","article-title":"Meta-analysis of biomarkers for severe dengue infections","volume":"5","author":"Soo","year":"2017","journal-title":"PeerJ"},{"key":"ref_5","unstructured":"Stone, W.L., Logan, L., and Varacallo, M. (2022, May 10). Physiology, Growth Factor, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK442024\/."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1096\/fba.2020-00015","article-title":"The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID-19?","volume":"2","author":"Hondermarck","year":"2020","journal-title":"FASEB Bioadv."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Da Silveira, L.T.C., Tura, B., and Santos, M. (2019). Systematic review of dengue vaccine efficacy. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-4369-5"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1093\/infdis\/jiw423","article-title":"Current Status of Dengue Therapeutics Research and Development","volume":"215","author":"Low","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_10","unstructured":"World Health Organization (WHO) (1997). Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control, World Health Organization. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/41988."},{"key":"ref_11","unstructured":"World Health Organization (WHO) (2009). Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control, World Health Organization. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/44188."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Becquart, P., Wauquier, N., Nkoghe, D., Ndjoyi-Mbiguino, A., Padilla, C., Souris, M., and Leroy, E.M. (2010). Acute dengue virus 2 infection in Gabonese patients is associated with an early innate immune response, including strong interferon alpha production. BMC Infect. Dis., 10.","DOI":"10.1186\/1471-2334-10-356"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Conroy, A.L., G\u00e9lvez, M., Hawkes, M., Rajwans, N., Liles, W.C., Villar-Centeno, L.A., and Kain, K.C. (2014). Host biomarkers distinguish dengue from leptospirosis in Colombia: A case-control study. BMC Infect. Dis., 14.","DOI":"10.1186\/1471-2334-14-35"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijid.2015.07.027","article-title":"Host biomarkers are associated with progression to dengue haemorrhagic fever: A nested case-control study","volume":"40","author":"Conroy","year":"2015","journal-title":"Int. J. Infect. Dis."},{"key":"ref_15","first-page":"370","article-title":"Association DENV1 and DENV2 infection with high serum levels of soluble thrombomodulin and VEGF in patients with dengue fever and dengue hemorrhagic fever","volume":"7","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Furuta, T., Murao, L.A., Lan, N.T., Huy, N.T., Huong, V.T., Thuy, T.T., Tham, V.D., Nga, C.T., Ha, T.T., and Ohmoto, Y. (2012). Association of mast cell-derived VEGF and proteases in Dengue shock syndrome. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001505"},{"key":"ref_17","first-page":"11","article-title":"Anticuerpos IgG4 espec\u00edficos anti Aedes aegypti como factor protector en ni\u00f1os con dengue grave","volume":"27","author":"Castro","year":"2019","journal-title":"Rev. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/infdis\/jiw494","article-title":"Severity of Plasma Leakage Is Associated with High Levels of Interferon \u03b3-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection","volume":"215","author":"Her","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kumar, Y., Liang, C., Bo, Z., Rajapakse, J.C., Ooi, E.E., and Tannenbaum, S.R. (2012). Serum Proteome and Cytokine Analysis in a Longitudinal Cohort of Adults with Primary Dengue Infection Reveals Predictive Markers of DHF. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001887"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/20477724.2018.1516417","article-title":"The predictive and diagnostic accuracy of vascular endothelial growth factor and pentraxin-3 in severe dengue","volume":"112","author":"Low","year":"2018","journal-title":"Pathog. Glob. Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2149\/tmh.2014-09","article-title":"The association of cytokines with severe dengue in children","volume":"42","author":"Mangione","year":"2014","journal-title":"Trop. Med. Health"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.3889\/oamjms.2019.621","article-title":"The Vascular Endothelium in Patients with Dengue Haemorrhagic Fever","volume":"7","author":"Bachtiar","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Nanda, J.D., Jung, C.J., Satria, R.D., Jhan, M.K., Shen, T.J., Tseng, P.C., Wang, Y.T., Ho, T.S., and Lin, C.F. (2021). Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression. J. Immunol. Res., 2021.","DOI":"10.1155\/2021\/7652569"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3855\/jidc.4542","article-title":"Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier","volume":"8","author":"Orsi","year":"2014","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/jmv.25529","article-title":"Study of serum VEGF levels in patients with severe dengue infection admitted in a tertiary care hospital in Kolkata","volume":"91","author":"Patra","year":"2019","journal-title":"J. Med. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Singla, M., Kar, M., Sethi, T., Kabra, S.K., Lodha, R., Chandele, A., and Medigeshi, G.R. (2016). Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India\u2014Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004642"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1128\/JVI.01642-06","article-title":"Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic fever","volume":"81","author":"Srikiatkhachorn","year":"2007","journal-title":"J. Virol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s13337-015-0296-2","article-title":"Elevated levels of vascular endothelial growth factor in adults with severe dengue infection","volume":"27","author":"Thakur","year":"2016","journal-title":"Virus Dis."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Tramontini Gomes de Sousa Cardozo, F., Baimukanova, G., Lanteri, M.C., Keating, S.M., Moraes Ferreira, F., Heitman, J., Pannuti, C.S., Pati, S., Romano, C.M., and Cerdeira Sabino, E. (2017). Serum from dengue virus-infected patients with and without plasma leakage differentially affects endothelial cells barrier function in vitro. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178820"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.femsim.2004.10.004","article-title":"Elevated levels of plasma VEGF in patients with dengue hemorrhagic fever","volume":"43","author":"Tseng","year":"2005","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Van de Weg, C.A., Pannuti, C.S., de Ara\u00fajo, E.S., van den Ham, H.J., Andeweg, A.C., Boas, L.S., Felix, A.C., Carvalho, K.I., de Matos, A.M., and Levi, J.E. (2013). Microbial translocation is associated with extensive immune activation in dengue virus infected patients with severe disease. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002236"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jcv.2014.05.001","article-title":"Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection","volume":"60","author":"Pannuti","year":"2014","journal-title":"J. Clin. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12967-017-1226-4","article-title":"Aberrant monocyte responses predict and characterize dengue virus infection in individuals with severe disease","volume":"15","author":"Yong","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4269\/ajtmh.2012.11-0606","article-title":"Cytokine factors present in dengue patient sera induces alterations of junctional proteins in human endothelial cells","volume":"87","author":"Appanna","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.virusres.2018.09.013","article-title":"Different aspects of platelet evaluation in dengue: Measurement of circulating mediators, ability to interact with the virus, the degree of activation and quantification of intraplatelet protein content","volume":"260","author":"Barros","year":"2019","journal-title":"Virus Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1097\/INF.0b013e31826fd456","article-title":"Alteration of cytokines and chemokines during febrile episodes associated with endothelial cell damage and plasma leakage in dengue hemorrhagic fever","volume":"31","author":"Butthep","year":"2012","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jcv.2013.10.022","article-title":"Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection","volume":"58","author":"Ndhlovu","year":"2013","journal-title":"J. Clin. Virol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Rathakrishnan, A., Wang, S.M., Hu, Y., Khan, A.M., Ponnampalavanar, S., Lum, L.C., Manikam, R., and Sekaran, S.D. (2012). Cytokine expression profile of dengue patients at different phases of illness. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052215"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1179\/146532807X220280","article-title":"The role of vascular endothelial growth factor leading to vascular leakage in children with dengue virus infection","volume":"27","author":"Sathupan","year":"2007","journal-title":"Ann. Trop. Paediatr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e248","DOI":"10.1016\/j.ijid.2008.11.028","article-title":"Relationship between circulating vascular endothelial growth factor and its soluble receptors in adults with dengue virus infection: A case-control study","volume":"13","author":"Seet","year":"2009","journal-title":"Int. J. Infect. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"148","DOI":"10.7705\/biomedica.v36i0.2878","article-title":"Regulators of endothelial integrity as severity predictors in dengue","volume":"36","author":"Figueroa","year":"2016","journal-title":"Biomedica"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s10753-013-9776-y","article-title":"Role of vascular endothelial growth factor (VEGF) in the neurological manifestations of dengue: A preliminary study","volume":"37","author":"Misra","year":"2014","journal-title":"Inflammation"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/infdis\/jiw220","article-title":"Association of microvascular function and endothelial biomarkers with clinical outcome in dengue: An observational study","volume":"214","author":"Yacoub","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/jmv.24205","article-title":"VEGF and its receptors in dengue virus infection","volume":"87","author":"Kalita","year":"2015","journal-title":"J. Med. Virol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bozza, F.A., Cruz, O.G., Zagne, S.M., Azeredo, E.L., Nogueira, R.M., Assis, E.F., Bozza, P.T., and Kubelka, C.F. (2008). Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity. BMC Infect. Dis., 8.","DOI":"10.1186\/1471-2334-8-86"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.humimm.2021.03.003","article-title":"Cytokine IP-10 and GM-CSF are prognostic biomarkers for severity in secondary dengue infection","volume":"82","year":"2021","journal-title":"Hum. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"681937","DOI":"10.3389\/fcimb.2021.681937","article-title":"Emergence of Dengue 4 as Dominant Serotype During 2017 Outbreak in South India and Associated Cytokine Expression Profile","volume":"11","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"218","DOI":"10.5114\/ceji.2017.69366","article-title":"Dengue virus and Japanese encephalitis virus infection of the central nervous system share similar profiles of cytokine accumulation in cerebrospinal fluid","volume":"42","author":"Li","year":"2017","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref_49","first-page":"31","article-title":"T helper (Th) 1 and Th2 cytokine expression profile in dengue and malaria infection using magnetic bead-based bio-plex assay","volume":"44","author":"Maneekan","year":"2013","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jcv.2017.02.007","article-title":"Serum cytokine\/chemokine profiles in patients with dengue fever (DF) and dengue hemorrhagic fever (FHD) by using protein array","volume":"89","author":"Oliveira","year":"2017","journal-title":"J. Clin. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Patro, A.R.K., Mohanty, S., Prusty, B.K., Singh, D.K., Gaikwad, S., Saswat, T., Chattopadhyay, S., Das, B.K., Tripathy, R., and Ravindran, B. (2019). Cytokine Signature Associated with Disease Severity in Dengue. Viruses, 11.","DOI":"10.3390\/v11010034"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Puc, I., Ho, T.C., Yen, K.L., Vats, A., Tsai, J.J., Chen, P.L., Chien, Y.W., Lo, Y.C., and Perng, G.C. (2021). Cytokine Signature of Dengue Patients at Different Severity of the Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062879"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijid.2019.09.007","article-title":"A clinical and epidemiological survey of the largest dengue outbreak in Southern Taiwan in 2015","volume":"88","author":"Wang","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1089\/vim.2019.0100","article-title":"Increase of Plasma TNF-\u03b1 Is Associated with Decreased Levels of Blood Platelets in Clinical Dengue Infection","volume":"33","author":"Meena","year":"2020","journal-title":"Viral Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s12936-015-0835-8","article-title":"Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co-infection","volume":"14","author":"Andrade","year":"2015","journal-title":"Malar J."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Cui, L., Lee, Y.H., Thein, T.L., Fang, J., Pang, J., Ooi, E.E., Leo, Y.S., Ong, C.N., and Tannenbaum, S.R. (2016). Serum Metabolomics Reveals Serotonin as a Predictor of Severe Dengue in the Early Phase of Dengue Fever. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004607"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Halsey, E.S., Baldeviano, G.C., Edgel, K.A., Vilcarromero, S., Sihuincha, M., and Lescano, A.G. (2016). Symptoms and Immune Markers in Plasmodium\/Dengue Virus Co-infection Compared with Mono-infection with Either in Peru. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004646"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2613.1999.00107.x","article-title":"Profile of transforming growth factor-beta 1 in patients with dengue haemorrhagic fever","volume":"80","author":"Agarwal","year":"1999","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1590\/S0074-02762006000400016","article-title":"Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease","volume":"101","author":"Azeredo","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s00705-015-2410-6","article-title":"Serum levels of IL-8, IFN\u03b3, IL-10, and TGF \u03b2 and their gene expression levels in severe and non-severe cases of dengue virus infection","volume":"160","author":"Pandey","year":"2015","journal-title":"Arch Virol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10096-015-2561-0","article-title":"Altered profile of regulatory T cells and associated cytokines in mild and moderate dengue","volume":"35","author":"Tillu","year":"2016","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.actatropica.2018.10.017","article-title":"Assessment of chemokine and cytokine signatures in patients with dengue infection: A hospital-based study in Kolkata, India","volume":"190","author":"Patra","year":"2019","journal-title":"Acta Trop."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/imm.12863","article-title":"Regulatory T-cells in acute dengue viral infection","volume":"154","author":"Jayaratne","year":"2018","journal-title":"Immunology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0035-9203(98)90800-8","article-title":"Plasma levels of tumour necrosis factor alpha and transforming growth factor beta-1 in children with dengue 2 virus infection in French Polynesia","volume":"92","author":"Laur","year":"1998","journal-title":"Trans. R Soc. Trop. Med. Hyg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/tropej\/fmq122","article-title":"Increase of plasminogen activator inhibitor-1 and decrease of transforming growth factor-b1 in children with dengue haemorrhagic fever in Indonesia","volume":"57","author":"Djamiatun","year":"2011","journal-title":"J. Trop. Pediatr."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Malavige, G.N., Huang, L.C., Salimi, M., Gomes, L., Jayaratne, S.D., and Ogg, G.S. (2012). Cellular and cytokine correlates of severe dengue infection. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050387"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Harenberg, A., de Montfort, A., Jantet-Blaudez, F., Bonaparte, M., Boudet, F., Saville, M., Jackson, N., and Guy, B. (2016). Cytokine Profile of Children Hospitalized with Virologically-Confirmed Dengue during Two Phase III Vaccine Efficacy Trials. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004830"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Dhenni, R., Yohan, B., Alisjahbana, B., Lucanus, A., Riswari, S.F., Megawati, D., Haryanto, S., Gampamole, D., Hayati, R.F., and Sari, K. (2021). Comparative cytokine profiling identifies common and unique serum cytokine responses in acute chikungunya and dengue virus infection. BMC Infect. Dis., 21.","DOI":"10.1186\/s12879-021-06339-6"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1179\/146532810X12786388978607","article-title":"Increased level of hepatocyte growth factor in children with dengue virus infection","volume":"30","author":"Voraphani","year":"2010","journal-title":"Ann. Trop. Paediatr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cyto.2016.12.025","article-title":"Hepatocyte growth factor in physiology and infectious diseases","volume":"98","author":"Imamura","year":"2017","journal-title":"Cytokine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/08977194.2018.1520229","article-title":"Exploitation of receptor tyrosine kinases by viral-encoded growth factors","volume":"36","author":"Lateef","year":"2018","journal-title":"Growth Factors"},{"key":"ref_72","first-page":"455","article-title":"Vascular endothelial growth factor (VEGF)\u2014Key factor in normal and pathological angiogenesis","volume":"59","author":"Melincovici","year":"2018","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/cphy.c170015","article-title":"Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators","volume":"8","author":"Bates","year":"2018","journal-title":"Compr. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"313842","DOI":"10.1155\/2015\/313842","article-title":"Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators","volume":"2015","author":"Monteiro","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1046\/j.1538-7836.2003.00208.x","article-title":"Thrombin induces angiogenesis and vascular endothelial growth factor expression in human endothelial cells: Possible relevance to HIF-1alpha","volume":"1","author":"Dupuy","year":"2003","journal-title":"J. Thromb. Haemost."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.vph.2014.05.005","article-title":"Regulation of tissue factor gene expression in monocytes and endothelial cells: Thromboxane A2 as a new player","volume":"62","author":"Bode","year":"2014","journal-title":"Vascul. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.micinf.2016.08.005","article-title":"Increased circulating procoagulant and anticoagulant factors as TF and TFPI according to severity or infecting serotypes in human dengue infection","volume":"19","author":"Solorzano","year":"2017","journal-title":"Microbes Infect."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Alkharsah, K.R. (2018). VEGF Upregulation in Viral Infections and Its Possible Therapeutic Implications. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061642"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrm1911","article-title":"VEGF receptor signalling\u2014In control of vascular function","volume":"7","author":"Olsson","year":"2006","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e20190945","DOI":"10.1084\/jem.20190945","article-title":"GM-CSF in inflammation","volume":"217","author":"Hamilton","year":"2020","journal-title":"J Exp Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"101516","DOI":"10.1016\/j.smim.2021.101516","article-title":"G-CSF\u2014A double edge sword in neutrophil mediated immunity","volume":"54","author":"Martin","year":"2021","journal-title":"Semin. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.3389\/fimmu.2018.01922","article-title":"GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function","volume":"9","author":"Sun","year":"2018","journal-title":"Front Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1182\/blood-2012-05-430090","article-title":"CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages","volume":"121","author":"Wu","year":"2013","journal-title":"Blood"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1423-0127-20-36","article-title":"Distinct regulation of dengue virus-induced inflammasome activation in human macrophage subsets","volume":"20","author":"Wu","year":"2013","journal-title":"J. Biomed. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.3389\/fimmu.2018.03007","article-title":"Neutrophil Activation and Early Features of NET Formation Are Associated With Dengue Virus Infection in Human","volume":"9","author":"Opasawatchai","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.febslet.2012.05.028","article-title":"Structural studies of the TGF-\u03b2s and their receptors\u2014Insights into evolution of the TGF-\u03b2 superfamily","volume":"586","author":"Hinck","year":"2012","journal-title":"FEBS Lett."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41413-017-0005-4","article-title":"Transforming growth factor-\u03b2 in stem cells and tissue homeostasis","volume":"6","author":"Xu","year":"2018","journal-title":"Bone Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","article-title":"TGF-\u03b2 activation and function in immunity","volume":"32","author":"Travis","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"a022236","DOI":"10.1101\/cshperspect.a022236","article-title":"Regulation of the Immune Response by TGF-\u03b2: From Conception to Autoimmunity and Infection","volume":"9","author":"Sanjabi","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Vargas, L.A., Hern\u00e1ndez-Flores, K.G., Thomas-Dupont, P., Izaguirre-Hern\u00e1ndez, I.Y., S\u00e1nchez-Marce, E.E., Remes-Ruiz, R., Fonseca-Coronado, S., Hern\u00e1ndez-Romano, P.A., Flores-Collins, M.E., and Vivanco-Cid, H. (2020). Characterization of the IL-17 and CD4+ Th17 Cells in the Clinical Course of Dengue Virus Infections. Viruses, 12.","DOI":"10.3390\/v12121435"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00024382-199608000-00007","article-title":"Differential effects of transforming growth factor-beta 1 on lipopolysaccharide induction of endothelial adhesion molecules","volume":"6","author":"Kang","year":"1996","journal-title":"Shock"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Karolczak, K., and Watala, C. (2021). Blood Platelets as an Important but Underrated Circulating Source of TGF\u03b2. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094492"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1002\/jmv.27879","article-title":"Suppression of TGF-\u03b2\/Smad2 signaling by GW788388 enhances DENV-2 clearance in macrophages","volume":"94","author":"Teixeira","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.clim.2009.01.015","article-title":"Combination of CTLA-4 and TGFbeta1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak","volume":"131","author":"Chen","year":"2009","journal-title":"Clin. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cyto.2018.10.019","article-title":"Diverse effects of platelet-derived growth factor-BB on cell signaling pathways","volume":"113","author":"Wang","year":"2019","journal-title":"Cytokine"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1742-481X.2009.00622.x","article-title":"Epidermal growth factor in clinical practice\u2014A review of its biological actions, clinical indications and safety implications","volume":"6","year":"2009","journal-title":"Int. Wound J."},{"key":"ref_97","first-page":"290","article-title":"The influence of platelet-derived products on angiogenesis and tissue repair: A concise update","volume":"6","author":"Smith","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1440-1746.2010.06549.x","article-title":"Hepatocyte growth factor twenty years on: Much more than a growth factor","volume":"26","author":"Nakamura","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cyto.2015.12.013","article-title":"The hepatocyte growth factor (HGF)-MET receptor tyrosine kinase signaling pathway: Diverse roles in modulating immune cell functions","volume":"82","author":"Ilangumaran","year":"2016","journal-title":"Cytokine"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.4049\/jimmunol.166.2.1241","article-title":"Hepatocyte growth factor is a regulator of monocyte-macrophage function","volume":"166","author":"Galimi","year":"2001","journal-title":"J. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3390\/biomedicines3010138","article-title":"HGF\/Met-Signaling Contributes to Immune Regulation by Modulating Tolerogenic and Motogenic Properties of Dendritic Cells","volume":"3","author":"Hieronymus","year":"2015","journal-title":"Biomedicines"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Coudriet, G.M., He, J., Trucco, M., Mars, W.M., and Piganelli, J.D. (2010). Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: Implications for inflammatory mediated diseases. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015384"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1182\/blood-2005-08-3141","article-title":"Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low\/neg accessory cells with dendritic-cell features","volume":"108","author":"Rutella","year":"2006","journal-title":"Blood"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jneuroim.2013.12.004","article-title":"The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells","volume":"267","author":"Molnarfi","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/hep.1840210119","article-title":"Serum hepatocyte growth factor levels in liver diseases: Clinical implications","volume":"21","author":"Shiota","year":"1995","journal-title":"Hepatology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.actatropica.2015.12.013","article-title":"Evaluation of aminotransferase abnormality in dengue patients: A meta analysis","volume":"156","author":"Wang","year":"2016","journal-title":"Acta Trop."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"582935","DOI":"10.3389\/fimmu.2021.582935","article-title":"Cytokines and Soluble HLA-G Levels in the Acute and Recovery Phases of Arbovirus-Infected Brazilian Patients Exhibiting Neurological Complications","volume":"12","author":"Almeida","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/infdis\/jix261","article-title":"Specific Biomarkers Associated with Neurological Complications and Congenital Central Nervous System Abnormalities from Zika Virus-Infected Patients in Brazil","volume":"216","author":"Kam","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/wdev.176","article-title":"The Fibroblast Growth Factor signaling pathway","volume":"4","author":"Ornitz","year":"2015","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1684\/ecn.2009.0155","article-title":"Inflammatory cells and chemokines sustain FGF2-induced angiogenesis","volume":"20","author":"Presta","year":"2009","journal-title":"Eur. Cytokine Netw."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1016\/j.celrep.2019.04.105","article-title":"Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production","volume":"27","author":"Cortese","year":"2019","journal-title":"Cell Rep."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Norshidah, H., Vignesh, R., and Lai, N.S. (2021). Updates on Dengue Vaccine and Antiviral: Where Are We Heading?. Molecules, 26.","DOI":"10.3390\/molecules26226768"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fcimb.2018.00398","article-title":"Cellular Targets for the Treatment of Flavivirus Infections","volume":"8","author":"Zakaria","year":"2018","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"7367","DOI":"10.1128\/JVI.00632-13","article-title":"The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase","volume":"87","author":"LaCroix","year":"2013","journal-title":"J. Virol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1172\/JCI89857","article-title":"Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects","volume":"127","author":"Bekerman","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.lfs.2017.10.027","article-title":"Gefitinib and pyrrolidine dithiocarbamate decrease viral replication and cytokine production in dengue virus infected human monocyte cultures","volume":"191","author":"Duran","year":"2017","journal-title":"Life Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"105721","DOI":"10.1016\/j.phrs.2021.105721","article-title":"Brivanib alaninate inhibited dengue virus proliferation through VEGFR2\/AMPK pathway","volume":"170","author":"Wan","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Chuang, F.K., Liao, C.L., Hu, M.K., Chiu, Y.L., Lee, A.R., Huang, S.M., Chiu, Y.L., Tsai, P.L., Su, B.C., and Chang, T.H. (2020). Antiviral Activity of Compound L3 against Dengue and Zika Viruses in Vitro and in Vivo. Int. J. Mol Sci., 21.","DOI":"10.3390\/ijms21114050"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2018.07.022","article-title":"Synergism between the tyrosine kinase inhibitor sunitinib and Anti-TNF antibody protects against lethal dengue infection","volume":"158","author":"Branche","year":"2018","journal-title":"Antivir. Res."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Peters, M.D.J., Godfrey, C., McInerney, P., Munn, Z., Tricco, A.C., and Khalil, H. (2020). Chapter 11: Scoping reviews. JBI Manual for Evidence Synthesis, JBI. Available online: https:\/\/synthesismanual.jbi.global.","DOI":"10.46658\/JBIRM-20-01"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Fiestas Solorzano, V.E., de Lima, R.C., and de Azeredo, E.L. (2022, March 10). Role of Growth Factors in the Pathogenesis of Dengue: Scoping Review Protocol. Available online: https:\/\/doi.org\/10.17605\/OSF.IO\/JEZV5.","DOI":"10.3390\/pathogens11101179"}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/10\/1179\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:53:12Z","timestamp":1760143992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/10\/1179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,13]]},"references-count":121,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["pathogens11101179"],"URL":"https:\/\/doi.org\/10.3390\/pathogens11101179","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,13]]}}}