{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:12:14Z","timestamp":1782767534032,"version":"3.54.5"},"reference-count":21,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Procalcitonin is gaining momentum in the study of protozoal sepsis, but its utility as a biomarker has yet to be fully discovered in human babesiosis. A total of 33 cases of acute babesiosis dating between 2012 and 2019 were retrospectively collected from Stony Brook University Hospital (SBUH) and Stony Brook South Hampton Hospital (SHH), both of which are located on Long Island, NY. Cases were cross-referenced for the need for ICU admission, and the procalcitonin levels were measured by the use of BRAHMS Elecsys assay at SBUH and BRAHMS Architect assay at SHH. Our study demonstrated that the log-transformed procalcitonin levels had a linear correlation with log-transformed maximum parasitemia, which suggests that procalcitonin directly correlates with parasitemia values. Furthermore, when comparing values that predict ICU admission, our ROC analysis of procalcitonin demonstrated similar AUC values to the percentage of parasitemia, suggesting that procalcitonin may assist in determining the severity of disease. We demonstrate that procalcitonin may directly correlate with the parasitemia percentage and have prognostic capabilities, which suggests that procalcitonin may have biomarker potential in human babesiosis.<\/jats:p>","DOI":"10.3390\/pathogens11111222","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T08:19:06Z","timestamp":1666599546000},"page":"1222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Procalcitonin as a Potential Biomarker in the Study of Babesiosis Caused by B. microti"],"prefix":"10.3390","volume":"11","author":[{"given":"Michael","family":"Lum","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Gauvin","sequence":"additional","affiliation":[{"name":"Division of General, Geriatric and Hospital Medicine, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia K.","family":"Pham","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Department of Medicine, Stony Brook Southampton Hospital, Southampton, NY 11968, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Papamanoli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-2441","authenticated-orcid":false,"given":"Eric D.","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1284-429X","authenticated-orcid":false,"given":"Andreas P.","family":"Kalogeropoulos","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Marcos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ijpara.2018.11.007","article-title":"Human babesiosis","volume":"49","author":"Krause","year":"2019","journal-title":"Int. J. Parasitol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/CMR.13.3.451","article-title":"Babesiosis","volume":"13","author":"Homer","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_3","first-page":"575","article-title":"The concentrations of the inflammatory markers the amino-terminal portion of C-type pronatriuretic peptide and procalcitonin in canine babesiosis caused by Babesia canis","volume":"84","author":"Brkljacic","year":"2014","journal-title":"Veterinarski Arhiv"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ijmm.2007.01.002","article-title":"First case of human babesiosis in Germany\u2013Clinical presentation and molecular characterization of the pathogen","volume":"297","author":"Tenter","year":"2007","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"896","DOI":"10.3201\/eid2005.121034","article-title":"Babesia venatorum Infection in Child, China","volume":"20","author":"Sun","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101435","DOI":"10.1016\/j.ttbdis.2020.101435","article-title":"Imported babesiosis caused by Babesia microti-A case report","volume":"11","author":"Chueca","year":"2020","journal-title":"Ticks Tick Borne Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.4269\/ajtmh.17-0146","article-title":"Risk Factors for Severe Infection, Hospitalization, and Prolonged Antimicrobial Therapy in Patients with Babesiosis","volume":"97","author":"Mareedu","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hildebrandt, A., Zintl, A., Montero, E., Hunfeld, K.P., and Gray, J. (2021). Human Babesiosis in Europe. Pathogens, 10.","DOI":"10.3390\/pathogens10091165"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1001\/archinte.158.19.2149","article-title":"Human Babesiosis in New York State: Review of 139 Hospitalized Cases and Analysis of Prognostic Factors","volume":"158","author":"White","year":"1998","journal-title":"Arch. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1128\/JCM.00655-10","article-title":"Use of plasma procalcitonin levels as an adjunct to clinical microbiology","volume":"48","author":"Gilbert","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1086\/319283","article-title":"Procalcitonin as a parameter of disease severity and risk of mortality in patients with Plasmodium falciparum malaria","volume":"183","author":"Chiwakata","year":"2001","journal-title":"J. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40560-017-0246-8","article-title":"Procalcitonin: A promising diagnostic marker for sepsis and antibiotic therapy","volume":"5","author":"Vijayan","year":"2017","journal-title":"J. Intensive Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/cyto.2001.0845","article-title":"The role of tumour necrosis factor-alpha in the pathogenesis of complicated falciparum malaria","volume":"14","author":"Odeh","year":"2001","journal-title":"Cytokine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"587131","DOI":"10.1155\/2015\/587131","article-title":"Human Coinfection with Borrelia burgdorferi and Babesia microti in the United States","volume":"2015","author":"Knapp","year":"2015","journal-title":"J. Parasitol. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s00277-002-0584-y","article-title":"Procalcitonin: A useful discriminator between febrile conditions of different origin in hemato-oncological patients?","volume":"82","author":"Binder","year":"2003","journal-title":"Ann. Hematol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3904\/kjim.2013.28.3.285","article-title":"Procalcitonin as a biomarker of infectious diseases","volume":"28","author":"Lee","year":"2013","journal-title":"Korean J. Intern. Med."},{"key":"ref_17","unstructured":"Brown, I., and Finnigan, N.A. (2022). Fever of Unknown Origin. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/clinids\/22.5.809","article-title":"Babesiosis in Patients with AIDS: A Chronic Infection Presenting as Fever of Unknown Origin","volume":"22","author":"Falagas","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.hrtlng.2008.01.003","article-title":"Fever of unknown origin (FUO) due to babesiosis in a immunocompetent host","volume":"37","author":"Cunha","year":"2008","journal-title":"Heart Lung"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/ajcp\/83.4.520","article-title":"Babesiosis: Problems in diagnosis using autoanalyzers","volume":"83","author":"Bruckner","year":"1985","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/jclinpath-2019-206382","article-title":"Flagging performance of Sysmex XN-10 haematology analyser for malaria detection","volume":"73","author":"Dumas","year":"2020","journal-title":"J. Clin. Pathol."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/11\/1222\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:01:22Z","timestamp":1760144482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/11\/11\/1222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,23]]},"references-count":21,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["pathogens11111222"],"URL":"https:\/\/doi.org\/10.3390\/pathogens11111222","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,23]]}}}