{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:16:21Z","timestamp":1789564581728,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Program of Hebei Province","award":["No. 17275506D"],"award-info":[{"award-number":["No. 17275506D"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Staphylococcus aureus (S. aureus) is a common opportunistic and zoonotic pathogen in the world and could easily cause human infections and food contaminations. This study investigated the sequence typing and resistance profiles of S. aureus isolates from patient and food samples in Shijiazhuang, China. A total of 101 S. aureus isolates were distributed into six clonal complexes (CCs) and 16 singletons. A total of 86 patient isolates were distributed into six clonal CCs and 12 singletons, including a new ST. CC59, CC5, CC22, and CC398 were the predominant CCs of patient isolates. A total of 15 foodborne S. aureus isolates were distributed into 3 CCs and 4 STs, and CC1 was the most prevalent CC. Moreover, 101 S. aureus isolates had high resistance to penicillin and low resistance to chloramphenicol and rifampicin. A total of 39 strains of methicillin-resistant Staphylococcus aureus (MRSA) were detected in this study, including thirty-eight strains of patient isolates (44.2%, 38\/86) and one strain of food isolates (6.7%, 1\/15). MRSA-ST5, MRSA-ST59, and MRSA-ST239 were the predominant MRSA isolates in hospitals. The present study explained the relationship between S. aureus isolated from patient and food samples and indicated the risks of S. aureus in infectious diseases.<\/jats:p>","DOI":"10.3390\/pathogens11111333","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T02:26:37Z","timestamp":1668392797000},"page":"1333","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular Characteristics and Antibiotic Resistance of Staphylococcus aureus Isolated from Patient and Food Samples in Shijiazhuang, China"],"prefix":"10.3390","volume":"11","author":[{"given":"Han","family":"Zhang","sequence":"first","affiliation":[{"name":"Basic Medicine College, Hebei University of Chinese Medicine, Shijiazhuang 050200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Qin","sequence":"additional","affiliation":[{"name":"Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang 050011, China"},{"name":"Hebei Key Laboratory of Unidentifiable Bacteria, Shijiazhuang 050011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiping","family":"Jin","sequence":"additional","affiliation":[{"name":"Basic Medicine College, Hebei University of Chinese Medicine, Shijiazhuang 050200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huidong","family":"Ju","sequence":"additional","affiliation":[{"name":"College of Chemical Technology, Shijiazhuang University, Shijiazhuang 050035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang 050011, China"},{"name":"Hebei Key Laboratory of Unidentifiable Bacteria, Shijiazhuang 050011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Li","sequence":"additional","affiliation":[{"name":"Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang 050011, China"},{"name":"Hebei Key Laboratory of Unidentifiable Bacteria, Shijiazhuang 050011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang 050011, China"},{"name":"Hebei Key Laboratory of Unidentifiable Bacteria, Shijiazhuang 050011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Gao","sequence":"additional","affiliation":[{"name":"Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang 050011, China"},{"name":"Hebei Key Laboratory of Unidentifiable Bacteria, Shijiazhuang 050011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuping","family":"Wei","sequence":"additional","affiliation":[{"name":"Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang 050011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Dong","sequence":"additional","affiliation":[{"name":"Basic Medicine College, Hebei University of Chinese Medicine, Shijiazhuang 050200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Lu","sequence":"additional","affiliation":[{"name":"Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang 050011, China"},{"name":"Hebei Key Laboratory of Unidentifiable Bacteria, Shijiazhuang 050011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Lv","sequence":"additional","affiliation":[{"name":"Basic Medicine College, Hebei University of Chinese Medicine, Shijiazhuang 050200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jiac.2019.10.003","article-title":"Metastatic infection during Staphylococcus aureus bacteremia","volume":"26","author":"Horino","year":"2020","journal-title":"J. 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