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causing disease. However, if they reach extra-intestinal sites, common cystitis to bloodstream infections may occur, putting patients at risk. To examine the human gut as a source of endogenous infections, we evaluated the E. coli clonal diversity of 18 inpatients\u2019 guts and their relationship with strains isolated from urinary tract infection (UTI) in the same hospital. Random amplified polymorphic DNA evaluated the clonal diversity, and the antimicrobial susceptibility was determined by disk diffusion. One isolate of each clone detected was sequenced, and their virulome and resistome were determined. Overall, 177 isolates were screened, among which 32 clones were identified (mean of two clones per patient), with ExPEC strains found in over 75% of the inpatients\u2019 guts. Endogenous infection was confirmed in 75% of the cases. ST10, ST59, ST69, ST131, and ST1193 clones and critical mobile drug-resistance encoding genes (blaCTX-M-15, blaOXA-1, blaDHA-1, aac(6\u2032)-lb-cr, mcr-1.26, qnrB4, and qnrB19) were identified in the gut of inpatients. The genomic analysis highlighted the diversity of the fecal strains, colonization by lactose-negative E. coli, the high frequency of ExPEC in the gut of inpatients without infections, and the presence of \u03b2-lactamase producing E. coli in the gut of inpatients regardless of the previous antibiotics\u2019 usage. Considering that we found more than one ExPEC clone in the gut of several inpatients, surveillance of inpatients\u2019 fecal pathogens may prevent UTI caused by E. coli in the hospital and dissemination of risk clones.<\/jats:p>","DOI":"10.3390\/pathogens11121528","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T01:52:34Z","timestamp":1670982754000},"page":"1528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Virulence Profile, Antibiotic Resistance, and Phylogenetic Relationships among Escherichia coli Strains Isolated from the Feces and Urine of Hospitalized Patients"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6407-5947","authenticated-orcid":false,"given":"Jos\u00e9 F.","family":"Santos-Neto","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio Experimental de Patogenicidade de Enterobact\u00e9rias, Disciplina de Microbiologia, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0833-4585","authenticated-orcid":false,"given":"Ana C. M.","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Experimental de Patogenicidade de Enterobact\u00e9rias, Disciplina de Microbiologia, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7054-0817","authenticated-orcid":false,"given":"J\u00fallia A. S.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Experimental de Patogenicidade de Enterobact\u00e9rias, Disciplina de Microbiologia, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana O.","family":"Trov\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Experimental de Patogenicidade de Enterobact\u00e9rias, Disciplina de Microbiologia, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda F.","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Alerta, Disciplina de Infectologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04039-032, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago B.","family":"Valiatti","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Alerta, Disciplina de Infectologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04039-032, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Gales","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Alerta, Disciplina de Infectologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04039-032, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L. V. R.","family":"Marques","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de Mogi Gua\u00e7u, Mogi Gua\u00e7u 13840-005, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel C.","family":"Pinaffi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Santa Cruz Medicina Diagn\u00f3stica, Mogi Gua\u00e7u 13840-052, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica A. M.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Experimental de Patogenicidade de Enterobact\u00e9rias, Disciplina de Microbiologia, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Enterobacterias, Disciplina de Microbiologia, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1057-6241","authenticated-orcid":false,"given":"Ivan N.","family":"Falsetti","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de Mogi Gua\u00e7u, Mogi Gua\u00e7u 13840-005, Brazil"},{"name":"Laborat\u00f3rio Santa Cruz Medicina Diagn\u00f3stica, Mogi Gua\u00e7u 13840-052, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-8705","authenticated-orcid":false,"given":"T\u00e2nia A. 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