{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:29:30Z","timestamp":1790285370210,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Introduction and hypothesis: Urinary tract infections (UTIs) are one of the most common complications of urogynecological surgeries. The risk of UTIs is increased by the catheterization of the bladder, intraoperative cystoscopy, and urine retention after the procedure. Due to increasing antibiotic resistance, there is a need to search for new methods of postoperative UTI prevention. Canephron is a mixture of century herbs, lovage roots, and rosemary leaves with diuretic, spasmolytic, anti-inflammatory, antibacterial, and nephroprotective properties. The aim of this study is to demonstrate the noninferiority of Canephron versus antibiotic prophylaxis with fosfomycin trometamol (FT), based on the collective results of postoperative urine culture analyses. Methods: One hundred and twenty-five female patients were randomized into two groups before undergoing urogynecological surgeries, including a control group (n = 67), which received one dose of 3 g of FT the day after the procedure, and a study group (n = 58), which received Canephron three times a day for 14 days, starting the day after the procedure. All the patients were assessed using the Acute Cystitis Symptom Score (ACSS). Results: UTIs were observed in 6.4% of the patients. There was no statistically significant difference between the use of FT and Canephron in terms of UTIs (Chi^2 N-1 = 0.8837; p = ns). Additional factors, such as menopausal status and the type of procedure performed, increased the risk of developing a UTI. Factors such as the body mass index (BMI) and parity had no correlation. Conclusions: Canephron is noninferior to FT in the prevention of postoperative UTIs. The use of such a phytotherapeutic drug may help to decrease antibiotic consumption, which is closely connected to the growing trend of antibiotic resistance.<\/jats:p>","DOI":"10.3390\/pathogens12010027","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T04:35:43Z","timestamp":1672115743000},"page":"27","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Postoperative Prevention of Urinary Tract Infections in Patients after Urogynecological Surgeries\u2014Nonantibiotic Herbal (Canephron) versus Antibiotic Prophylaxis (Fosfomycin Trometamol): A Parallel-Group, Randomized, Noninferiority Experimental Trial"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3466-2478","authenticated-orcid":false,"given":"Sara","family":"Wawrysiuk","sequence":"first","affiliation":[{"name":"2nd Department of Gynaecology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Rechberger","sequence":"additional","affiliation":[{"name":"2nd Department of Gynaecology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4258-0133","authenticated-orcid":false,"given":"Agnieszka","family":"Kubik-Komar","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Computer Science, University of Life Sciences in Lublin, ul. G\u0142\u0119boka 28, 20-950 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-5594","authenticated-orcid":false,"given":"Aleksandra","family":"Kolodynska","sequence":"additional","affiliation":[{"name":"2nd Department of Gynaecology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1304-5403","authenticated-orcid":false,"given":"Kurt","family":"Naber","sequence":"additional","affiliation":[{"name":"Department of Urology, Technical University of Munich, Arcisstrasse 21, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1902-6484","authenticated-orcid":false,"given":"Pawel","family":"Miotla","sequence":"additional","affiliation":[{"name":"2nd Department of Gynaecology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1007\/s00192-018-3767-3","article-title":"Urinary microbes and postoperative urinary tract infection risk in urogynecologic surgical patients","volume":"29","author":"Gao","year":"2018","journal-title":"Int. Urogynecol. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/01.AOG.0000255975.24668.f2","article-title":"Complications of sling surgery among female Medicare beneficiaries","volume":"109","author":"Anger","year":"2007","journal-title":"Obstet. 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