{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:43:37Z","timestamp":1760147017591,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2014\/07331-5","Finance Code 001"],"award-info":[{"award-number":["2014\/07331-5","Finance Code 001"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior \u2013 Brasil (CAPES)","award":["2014\/07331-5","Finance Code 001"],"award-info":[{"award-number":["2014\/07331-5","Finance Code 001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Schistosomiasis is one of the most important human helminthiases worldwide. Praziquantel is the current treatment, and no vaccine is available until the present. Thus, the presented study aimed to evaluate the immunization effects with recombinant Schistosoma mansoni enzymes: Adenosine Kinase (AK) and Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT), as well as a MIX of the two enzymes. Female Balb\/c mice were immunized in three doses, and 15 days after the last immunization, animals were infected with S. mansoni. Our results showed that the group MIX presented a reduction in the eggs in feces by 30.74% and 29%, respectively, in the adult worms. The groups AK, HGPRT and MIX could produce IgG1 antibodies, and the groups AK and MIX produced IgE antibodies anti-enzymes and anti-S. mansoni total proteins. The groups AK, HGPRT and MIX induced a reduction in the eosinophils in the peritoneal cavity. Besides, the group AK showed a decrease in the number of hepatic granulomas (41.81%) and the eggs present in the liver (42.30%). Therefore, it suggests that immunization with these enzymes can contribute to schistosomiasis control, as well as help to modulate experimental infection inducing a reduction of physiopathology in the disease.<\/jats:p>","DOI":"10.3390\/pathogens12010069","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T04:07:09Z","timestamp":1672632429000},"page":"69","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Immunization with Recombinant Schistosoma mansoni Enzymes AK and HGPRT: Murine Infection Control"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4868-9148","authenticated-orcid":false,"given":"Ana Carolina Maragno","family":"Fattori","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o e Doen\u00e7as Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisandra de A.","family":"Montija","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o e Doen\u00e7as Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3970-7834","authenticated-orcid":false,"given":"Bruna D. de L.","family":"Fragelli","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o e Doen\u00e7as Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo de O.","family":"Correia","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o e Doen\u00e7as Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia Aparecida","family":"de Castro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o e Doen\u00e7as Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Romanello","sequence":"additional","affiliation":[{"name":"Departamento de Sa\u00fade e Psicologia, Universidade do Estado de Minas Gerais, Ituiutaba 38302-192, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila T.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04039-032, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silmara M.","family":"Allegretti","sequence":"additional","affiliation":[{"name":"Instituto de Biologia, Departamento de Biologia Animal, Universidade Estadual de Campinas, Campinas 13083-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson G.","family":"Soares","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Citopatologia, Departamento de Patologia e Medicina Legal, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto D.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, S\u00e3o Carlos 13566-590, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda de F.","family":"Anibal","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o e Doen\u00e7as Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,1]]},"reference":[{"key":"ref_1","unstructured":"WHO (World Health Organization) (2022, March 20). 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