{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:14:28Z","timestamp":1776867268275,"version":"3.51.2"},"reference-count":20,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T00:00:00Z","timestamp":1673049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>We evaluated the effect of macrolide-resistant mutations in the Mycoplasma\u00a0pneumoniae 23S rRNA gene on the severity of lower respiratory tract infections in immunocompetent young adults treated at the Smolensk Military Hospital between 25 October 2017, and 17 November 2021. All analyzed cases represented a non-severe infection of the lower respiratory tract: 44 case histories with community-acquired pneumonia and 20 cases with acute bronchitis. The presence of mutations in the gene 23S rRNA of M. pneumoniae was determined with standard Sanger sequencing. The macrolide-resistant genotype was found in 4\/44 (9.1%) of the samples of the patients with pneumonia and in 3\/20 (15%) of the samples of the patients with acute bronchitis. The analyzed cases with identified M. pneumoniae carrying a mutation in the 23S rRNA gene did not show any differences in the clinical presentation in terms of disease severity caused by M. pneumoniae with the wild-type (WT) phenotype.<\/jats:p>","DOI":"10.3390\/pathogens12010103","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T01:36:17Z","timestamp":1673228177000},"page":"103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Course of Lower Respiratory Tract Infection in Young People Treated at the Military Hospital of Smolensk Garrison with Detected Mycoplasma pneumoniae Carrying a Macrolide-Resistant Mutation in 23S rRNA Gene"],"prefix":"10.3390","volume":"12","author":[{"given":"Inna Alexandrovna","family":"Edelstein","sequence":"first","affiliation":[{"name":"Laboratory Molecular Diagnostics, Institute of Antimicrobial Chemotherapy, Smolensk State Medical University Federal State Budgetary Educational Institution of Higher Education \u00abSmolensk State Medical University\u00bb of the Ministry of Healthcare of the Russian Federation, Smolensk 214019, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga Vladimirovna","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Brach No 4 of FSGI \u00ab1586 MCH\u00bb of the Ministry of Defense of the Russian Federation, Smolensk 214012, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg Igorevich","family":"Romashov","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Brach No 4 of FSGI \u00ab1586 MCH\u00bb of the Ministry of Defense of the Russian Federation, Smolensk 214012, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-1113","authenticated-orcid":false,"given":"Roman Sergeevich","family":"Kozlov","sequence":"additional","affiliation":[{"name":"Laboratory Molecular Diagnostics, Institute of Antimicrobial Chemotherapy, Smolensk State Medical University Federal State Budgetary Educational Institution of Higher Education \u00abSmolensk State Medical University\u00bb of the Ministry of Healthcare of the Russian Federation, Smolensk 214019, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,7]]},"reference":[{"key":"ref_1","unstructured":"Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (2020). 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Res."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/12\/1\/103\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:02:25Z","timestamp":1760119345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/12\/1\/103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,7]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["pathogens12010103"],"URL":"https:\/\/doi.org\/10.3390\/pathogens12010103","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,7]]}}}