{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:51:27Z","timestamp":1784951487420,"version":"3.55.0"},"reference-count":67,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French National Research Agency (ANR)","award":["ANR-21-CE14-0012"],"award-info":[{"award-number":["ANR-21-CE14-0012"]}]},{"name":"French National Research Agency (ANR)","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}]},{"name":"French Government\u2019s Investissement d\u2019Avenir program, Laboratoire d\u2019Excellence \u201cIntegrative Biology of Emerging Infectious Diseases\u201d","award":["ANR-21-CE14-0012"],"award-info":[{"award-number":["ANR-21-CE14-0012"]}]},{"name":"French Government\u2019s Investissement d\u2019Avenir program, Laboratoire d\u2019Excellence \u201cIntegrative Biology of Emerging Infectious Diseases\u201d","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The enormous volume of blood ingested by hard ticks during their long attachment period is without a doubt the hallmark of their biology. Maintaining a homeostatic balance between ion and water intake and loss during their feeding is critical to preventing osmotic stress and death. Exactly 50 years ago, Kaufman and Phillips published a series of three consecutive papers on \u201cIon and water balance in the ixodid tick Dermacentor andersoni\u201d, Journal of Experimental Biology (1973): I. Routes of ion and water excretion, 58: 523\u201336; II. Mechanism and control of salivary secretion 58: 537\u2013547; and III. Influence of monovalent ions and osmotic pressure on salivary secretion 58: 549\u2013564. This classic series significantly expanded our knowledge of the unique regulatory processes governing ion and water balance in fed ixodid ticks, highlighting its uniqueness among the blood-feeding arthropods. Their pioneer work had an enormous impact on understanding the vital role of salivary glands in these actions, and ultimately provided a consequential stepping stone for a new era of hard tick salivary gland physiological research.<\/jats:p>","DOI":"10.3390\/pathogens12030385","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T02:02:56Z","timestamp":1677636176000},"page":"385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["50 Years since Kaufman and Phillips\u2019 Groundbreaking Trilogy Elucidating Ion and Water Homeostasis in Ixodid Ticks"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4472-1016","authenticated-orcid":false,"given":"Ladislav","family":"\u0160imo","sequence":"first","affiliation":[{"name":"Laboratoire de Sant\u00e9 Animale, UMR BIPAR, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, INRAE, ANSES, F-94700 Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1242\/jeb.30.3.358","article-title":"Active Transport of Potassium by the Malpighian Tubules of Insects","volume":"30","author":"Ramsay","year":"1953","journal-title":"J. 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