{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:00:37Z","timestamp":1783040437275,"version":"3.54.6"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Background: The accurate estimation of the prevalence of mpox-induced ophthalmic lesions will enable health departments to allocate resources more effectively during the ongoing mpox pandemic. The aim of this meta-analysis was to estimate the global prevalence of ophthalmic manifestations in mpox patients. Methods: A systematic search was carried out in seven databases\u2014Pub Med, Scopus, Web of Science, EMBASE, ProQuest, EBSCOHost, and Cochrane\u2014for studies published on or before 12 December 2022. The pooled prevalence of ophthalmic manifestations was estimated by the random effects model. Risk of bias assessment of the studies and sub-group analysis to explain heterogeneity were undertaken. Results: Overall, 12 studies were included, with 3239 confirmed mpox cases, among which 755 patients reported ophthalmic manifestations. The pooled prevalence of ophthalmic manifestations was 9% (95% confidence interval (CI), 3\u201324). Studies from Europe reported a very low prevalence of ocular manifestations of 0.98% (95% CI 0.14\u20132.31), compared to studies from Africa with a substantially higher prevalence of 27.22% (95% CI 13.69\u201343.26). Conclusions: A wide variation in the prevalence of ocular manifestations among mpox patients was observed globally. Healthcare workers involved in mpox-endemic African countries should be aware of ocular manifestations for early detection and management.<\/jats:p>","DOI":"10.3390\/pathogens12030452","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:04:46Z","timestamp":1678763086000},"page":"452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Ophthalmic Manifestations of the Monkeypox Virus: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3898-5450","authenticated-orcid":false,"given":"Aravind P.","family":"Gandhi","sequence":"first","affiliation":[{"name":"Department of Community Medicine, ESIC Medical College & Hospital, Sanathnagar, Hyderabad 500038, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3630-5300","authenticated-orcid":false,"given":"Parul Chawla","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijaya K.","family":"Padhi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mokanpally","family":"Sandeep","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Hyderabad, Telangana 500046, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0063-0339","authenticated-orcid":false,"given":"Tarun Kumar","family":"Suvvari","sequence":"additional","affiliation":[{"name":"Medicine and Surgery, Rangaraya Medical College, Kakinada 533003, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3418-8171","authenticated-orcid":false,"given":"Muhammad Aaqib","family":"Shamim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur 342005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7614-8587","authenticated-orcid":false,"given":"Prakasini","family":"Satapathy","sequence":"additional","affiliation":[{"name":"Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2695-8714","authenticated-orcid":false,"given":"Ranjit","family":"Sah","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu 46000, Nepal"},{"name":"Department of Microbiology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune 411018, Maharashtra, India"},{"name":"Datta Meghe Institute of Higher Education and Research, Jawaharlal Nehru Medical College, Wardha 442001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7267-0204","authenticated-orcid":false,"given":"Darwin A.","family":"Le\u00f3n-Figueroa","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Humana, Universidad de San Mart\u00edn de Porres, Chiclayo 15011, Peru"},{"name":"Centro de Investigaci\u00f3n en Atenci\u00f3n Primaria en Salud, Universidad Peruana Cayetano Heredia, Lima 15102, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-2192","authenticated-orcid":false,"given":"Alfonso J.","family":"Rodriguez-Morales","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Biomedicina, Faculty of Medicine, Fundacion Universitaria Autonoma de las Am\u00e9ricas, Sede Pereira, Risaralda, Pereira 660003, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-1407","authenticated-orcid":false,"given":"Joshuan J.","family":"Barboza","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad Cesar Vallejo, Trujillo 13007, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0022-8382","authenticated-orcid":false,"given":"Arkadiusz","family":"Dziedzic","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry with Endodontics, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"ref_1","first-page":"593","article-title":"A Human Infection Caused by Monkeypox Virus in Basankusu Territory, Democratic Republic of the Congo","volume":"46","author":"Ladnyj","year":"1972","journal-title":"Bull. 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