{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:48:39Z","timestamp":1791557319655,"version":"4.3.4"},"reference-count":68,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Laboratorio de Inmunolog\u00eda de Hongos, Facultad de Medicina, UNAM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Histoplasmosis is one of the systemic mycoses that can involve the Central Nervous System (CNS), and it is caused by the dimorphic ascomycete species of the Histoplasma capsulatum complex. Once in the CNS, this pathogen causes life-threatening injuries that are associated with clinical manifestations of meningitis, focal lesions (abscesses, histoplasmomas), and spinal cord injuries. The present review provides updated data and highlights a particular vision regarding this mycosis and its causative agent, as well as its epidemiology, clinical forms, pathogenesis, diagnosis, and therapy, focusing on the CNS.<\/jats:p>","DOI":"10.3390\/pathogens12050681","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T02:56:51Z","timestamp":1683255411000},"page":"681","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Central Nervous System Histoplasmosis: An Updated Insight"],"prefix":"10.3390","volume":"12","author":[{"given":"Jos\u00e9 Antonio","family":"Ram\u00edrez","sequence":"first","affiliation":[{"name":"Unidad de Micolog\u00eda, Departamento de Microbiolog\u00eda-Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), CDMX, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-9995","authenticated-orcid":false,"given":"Mar\u00eda del Roc\u00edo","family":"Reyes-Montes","sequence":"additional","affiliation":[{"name":"Unidad de Micolog\u00eda, Departamento de Microbiolog\u00eda-Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), CDMX, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Rodr\u00edguez-Arellanes","sequence":"additional","affiliation":[{"name":"Unidad de Micolog\u00eda, Departamento de Microbiolog\u00eda-Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), CDMX, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-7922","authenticated-orcid":false,"given":"Armando","family":"P\u00e9rez-Torres","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), CDMX, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia","family":"Taylor","sequence":"additional","affiliation":[{"name":"Unidad de Micolog\u00eda, Departamento de Microbiolog\u00eda-Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), CDMX, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"ref_1","unstructured":"Mojan, R.M., and Benedik, M. 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