{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:26:52Z","timestamp":1784222812378,"version":"3.55.0"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>(1) Background: The human papillomavirus (HPV) is the most common agent related to sexually transmitted infections in the general population. Its genotypes are classified into two main classes, high-risk genotypes and low-risk genotypes, according to their capacity to induce cancers. The low-risk class (types 6 and 11) is associated with anogenital and genital lesions. The high-risk class is responsible for up to 4.5% of all new cancer cases yearly. The aim of this study was to evaluate the incidence of HPV-related hospitalizations and its trend in a southern Italian region for the years 2015\u20132021. (2) Methods: This was a retrospective study performed in the Abruzzo region, Italy. All admissions for the period 2015\u20132021 were extracted from the hospital discharge record (HDR). (3) Results: During the study period (2015\u20132021), a total of 5492 hospitalizations attributable to HPV infection occurred in the Abruzzo region, Italy. A significant number of admissions were related to cervical cancer (3386 cases) and genital warts (638 cases). The trend declined for all diagnoses except for penile cancer admissions. Considering the first year of the pandemic (year 2020), a decrease in the standardized incidence of the majority of the diseases considered was reported, particularly among cases of cervical cancer. (4) Conclusions: HPV-related hospitalizations decreased in Abruzzo during study period. These results could be useful to LHAs and policy-makers in improving vaccination coverage and screening adherence.<\/jats:p>","DOI":"10.3390\/pathogens12050725","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T07:35:50Z","timestamp":1684395350000},"page":"725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Burden of HPV-Related Hospitalizations: Analysis of Hospital Discharge Records from the Years 2015\u20132021 from a Southern Italian Region"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-7611","authenticated-orcid":false,"given":"Giuseppe","family":"Di Martino","sequence":"first","affiliation":[{"name":"Department of Medicine and Ageing Sciences, \u201cG. d\u2019Annunzio\u201d University of Chieti-Pescara, 66100 Chieti, Italy"},{"name":"Unit of Hygiene, Epidemiology and Public Health, Local Health Authority of Pescara, 65100 Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-2460","authenticated-orcid":false,"given":"Fabrizio","family":"Cedrone","sequence":"additional","affiliation":[{"name":"Hospital Management, Local Health Authority of Pescara, 65100 Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-8960","authenticated-orcid":false,"given":"Pamela","family":"Di Giovanni","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u201cG. d\u2019Annunzio\u201d University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Tognaccini","sequence":"additional","affiliation":[{"name":"School of Public Health, \u201cLa Sapienza\u201d University of Rome, 00100 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Trebbi","sequence":"additional","affiliation":[{"name":"School of Public Health, \u201cLa Sapienza\u201d University of Rome, 00100 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, \u201cLa Sapienza\u201d University of Rome, 00100 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5077-515X","authenticated-orcid":false,"given":"Tommaso","family":"Staniscia","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Sciences, \u201cG. d\u2019Annunzio\u201d University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/cncy.21789","article-title":"Infections with multiple high-risk HPV types are associated with high-grade and persistent low-grade intraepithelial lesions of the cervix","volume":"125","author":"Pellegrini","year":"2017","journal-title":"Cancer Cytopathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/978-1-59745-416-2_22","article-title":"Epidemiology of Human Papilloma Virus (HPV) in Cervical Mucosa","volume":"471","author":"Chauhan","year":"2009","journal-title":"Methods Mol. 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