{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:17:50Z","timestamp":1760149070709,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Infection with Leishmania amazonensis and L. mexicana may lead to diffuse cutaneous leishmaniasis. The cure is exceptional, especially for the strange case of this lady. Case report: The patient acquired the disease in childhood and remained with lesions for over 30 years, albeit several treatments. She worsened after a pregnancy, developing disseminated lesions. Miltefosine with amphotericin B and pentamidine resulted in remission. Lesions reappeared after one year, accompanied by intra-nasal infiltration of the disease. The nasal spraying of a single ampoule of pentavalent antimoniate resulted in the sustained disappearance of the nasal symptoms and all the cutaneous lesions. After over eight years, she remains disease-free, albeit under renal replacement therapy. The high nasal mucosal antimonial concentration may explain the long-lasting cure via new MHC class I epitope-specific CD8+ cell clones against L. amazonensis present in the nasal mucosa.<\/jats:p>","DOI":"10.3390\/pathogens12070890","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T01:14:12Z","timestamp":1688087652000},"page":"890","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Extraordinary Case of a Woman with a 30-Year-Long Diffuse Leishmaniasis Cured with One Single Ampoule of Intranasal Pentavalent Antimoniate"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3405-0386","authenticated-orcid":false,"given":"Sheila V. C. B.","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Cl\u00ednica Dermatol\u00f3gica, Hospital Get\u00falio Vargas, Teresina 64001-200, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-7978","authenticated-orcid":false,"given":"Dorcas L.","family":"Costa","sequence":"additional","affiliation":[{"name":"Centro de Agravos Tropicais Emergentes e Negligenciados, Universidade Federal do Piau\u00ed, Teresina 64000-450, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o da J.","family":"Cantinho-Junior","sequence":"additional","affiliation":[{"name":"Hospital de Urg\u00eancia de Teresina, Teresina 64017-775, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 N.","family":"Vieira-Junior","sequence":"additional","affiliation":[{"name":"Instituto de Doen\u00e7as Tropicais Natan Portella, Teresina 64002-510, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1017-3012","authenticated-orcid":false,"given":"Edna A. Y.","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-8364","authenticated-orcid":false,"given":"Rubens N.","family":"Costa","sequence":"additional","affiliation":[{"name":"Centro de Terapia Renal, Teresina 64003-075, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8864-6580","authenticated-orcid":false,"given":"Ant\u00f4nio C. G.","family":"Costa-Filho","sequence":"additional","affiliation":[{"name":"Hospital Santa Maria, Teresina 64076-410, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4680-6045","authenticated-orcid":false,"given":"Ronald da C.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Especializada, Universidade Federal do Piau\u00ed, Teresina 64049-550, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-3704","authenticated-orcid":false,"given":"Silvia R. B.","family":"Uliana","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-090, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8472-7500","authenticated-orcid":false,"given":"Jenicer K. U. 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