{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:34Z","timestamp":1787029234401,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>This study aimed to investigate the histopathological changes associated with SARS-CoV-2 infection in placentas. A case series of anatomopathological analysis was conducted on the placentas of pregnant women with SARS-CoV-2 who delivered between March and December 2020 at Santo Amaro Hospital (HSA) in Salvador, Brazil. Out of the 29 placentas examined, the median weight was 423.0 (IQR: 385.0\u2013521.0) g. Among them, 58.3% (n = 14) had inadequate weight relative to the newborn\u2019s weight. The histopathological findings revealed that 86.2% (n = 25) of the placentas had poorly defined lobes, and the fetal and maternal surface color was normal in 89.7% (n = 26) and 93.1% (n = 27), respectively. Additionally, 51.7% (n = 15) of the umbilical cords displayed hypercoiling. The most frequent microscopic finding was infarction, present in 35.3% (n = 6) of the cases, followed by 11.8% (n = 2) for each of chorioamnionitis, chronic villitis, focal perivillositis, and laminar necrosis. Analysis of the umbilical cords identified 23.5% (n = 4) cases of intervillous thrombosis, while amnion analysis showed 13.8% (n = 4) cases of squamous metaplasia. Extraplacental membrane examination revealed fibrin deposition in 93.1% (n = 27) of the cases, necrosis in 62.0% (n = 18), calcifications in 51.7% (n = 15), cysts in 37.9% (n = 11), neutrophilic exudate in 17.2% (n = 5), thrombosis in 13.7% (n = 4), and delayed placental maturation in 6.9% (n = 2). All analyzed placentas exhibited histopathological changes, primarily vascular and inflammatory, which indicate SARS-CoV-2 infection in term pregnancies. These alterations could be associated with impaired placental function, fetal growth restriction, preeclampsia, and prematurity. However, further prospective studies are required to validate the type, prevalence, and prognosis of each of these changes.<\/jats:p>","DOI":"10.3390\/pathogens12101197","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:55:01Z","timestamp":1695718501000},"page":"1197","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Histological Alterations in Placentas of Pregnant Women with SARS-CoV-2 Infection: A Single-Center Case Series"],"prefix":"10.3390","volume":"12","author":[{"given":"Jesus Enrique","family":"Pati\u00f1o Escarcina","sequence":"first","affiliation":[{"name":"Jos\u00e9 Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, Brazil"},{"name":"Collective Health Institute, Universidade Federal da Bahia, Salvador 40110-040, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-2776","authenticated-orcid":false,"given":"Ana Keila Carvalho Vieira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Jos\u00e9 Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mal\u00fa Oliveira de Ara\u00fajo","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Bahiana School of Medicine and Public Health, Salvador 40290-000, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Santos Santana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, UniFTC University Center, Salvador 41720-200, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2197-5419","authenticated-orcid":false,"given":"Luiza Andrade","family":"Agareno","sequence":"additional","affiliation":[{"name":"Jos\u00e9 Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Andrade","family":"Garboggini","sequence":"additional","affiliation":[{"name":"Clim\u00e9rio de Oliveira Maternity, Salvador 40055-150, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela de S\u00e1","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Clim\u00e9rio de Oliveira Maternity, Salvador 40055-150, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Campos","family":"Duarte","sequence":"additional","affiliation":[{"name":"Clim\u00e9rio de Oliveira Maternity, Salvador 40055-150, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Lago","family":"Morbeck","sequence":"additional","affiliation":[{"name":"Jos\u00e9 Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edcia Maria Oliveira","family":"Moreira","sequence":"additional","affiliation":[{"name":"Jos\u00e9 Silveira Foundation, Center for Research, Learning and Innovation, Salvador 40210-320, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The Species Severe Acute Respiratory Syndrome-Related Coronavirus: Classifying 2019-NCoV and Naming It SARS-CoV-2","volume":"5","author":"Gorbalenya","year":"2020","journal-title":"Nat. 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