{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:47:06Z","timestamp":1792273626441,"version":"4.4.0"},"reference-count":48,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The aim of our study was to evaluate the impact of T. gondii status on eosinophils count (EOS), the eosinophil-to-lymphocyte ratio (ELR), and the eosinophil-to-neutrophil-to-lymphocytes ratio (ENLR) before and after cannabis cessation in patients with psychiatric disorders. One hundred and eighty-eight patients were included in the study. T. gondii, EOS, ELR, ENLR, and urinary cannabis were measured at baseline and after 4 weeks of cannabis cessation. Highest levels and increase of PNE (p = 0.02), ENLR levels (p = 0.031) and highest level of ELR (p = 0.03) were found in patients after cannabis cessation only in patients positive for T. gondii serology (Toxo+ group). At four weeks, significant interactions between cannabis and T. gondii status for EOS (p = 0.038), and for ENLR (p = 0.043) levels were found, as well as for the evolution between baseline and 4 weeks for ENLR level (p = 0.049). After cannabis cessation, we found a positive correlation between negative symptoms and EOS levels at 4 weeks in the Toxo+ group. This study shows that the increase of inflammation after cannabis cessation might be modulated by T. gondii seropositivity status in patients after cannabis cessation.<\/jats:p>","DOI":"10.3390\/pathogens12111333","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T08:08:58Z","timestamp":1699517338000},"page":"1333","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Modulated Role of Toxoplasma gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation"],"prefix":"10.3390","volume":"12","author":[{"given":"Bruno","family":"Romeo","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Addictology, Paul Brousse Hospital, APHP, 94800 Villejuif, France"},{"name":"Unit\u00e9 de Recherche UR, Psychiatrie-Comorbidit\u00e9s-Addictions (PSYCOMadd), Paris Saclay University, 94800 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Lestra","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictology, Paul Brousse Hospital, APHP, 94800 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Martelli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictology, Paul Brousse Hospital, APHP, 94800 Villejuif, France"},{"name":"Unit\u00e9 de Recherche UR, Psychiatrie-Comorbidit\u00e9s-Addictions (PSYCOMadd), Paris Saclay University, 94800 Villejuif, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1299, Research unit, NeuroImaging and Psychiatry, Paris Sud University-Paris Saclay University, Paris Descartes University, Digiteo Labs, 91190 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Amirouche","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictology, Paul Brousse Hospital, APHP, 94800 Villejuif, France"},{"name":"Unit\u00e9 de Recherche UR, Psychiatrie-Comorbidit\u00e9s-Addictions (PSYCOMadd), Paris Saclay University, 94800 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine","family":"Benyamina","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictology, Paul Brousse Hospital, APHP, 94800 Villejuif, France"},{"name":"Unit\u00e9 de Recherche UR, Psychiatrie-Comorbidit\u00e9s-Addictions (PSYCOMadd), Paris Saclay University, 94800 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Hamdani","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche UR, Psychiatrie-Comorbidit\u00e9s-Addictions (PSYCOMadd), Paris Saclay University, 94800 Villejuif, France"},{"name":"C\u00e9diapsy, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1001\/jamapsychiatry.2021.1590","article-title":"Association of Toxoplasma gondii Seropositivity With Cognitive Function in Healthy People: A Systematic Review and Meta-analysis","volume":"78","author":"Sutterland","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1017\/S0950268813002756","article-title":"Incidence and prevalence of Toxoplasma gondii infection in women in France, 1980\u20132020: Model-based estimation","volume":"142","author":"Nogareda","year":"2014","journal-title":"Epidemiol. 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