{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:31:35Z","timestamp":1776205895609,"version":"3.50.1"},"reference-count":14,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T00:00:00Z","timestamp":1700870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"NIH\/National Institute of General Medicine Sciences (NIGMS)","doi-asserted-by":"publisher","award":["SC2GM144168"],"award-info":[{"award-number":["SC2GM144168"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Malaria, a devastating disease transmitted by mosquitoes, continues to plague many regions worldwide, affecting millions of lives annually [...]<\/jats:p>","DOI":"10.3390\/pathogens12121389","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:32:03Z","timestamp":1701055923000},"page":"1389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pathology of Severe Malaria"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8914-7740","authenticated-orcid":false,"given":"Julio","family":"Gallego-Delgado","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Lehman College, The City University of New York, Bronx, New York, NY 10468, USA"},{"name":"Ph.D. Program in Biology, The Graduate Center, The City University of New York, New York, NY 10016, USA"},{"name":"Ph.D. Program in Biochemistry, The Graduate Center, The City University of New York, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,25]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022). World Malaria Report 2022, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.4269\/ajtmh.20-1351","article-title":"Estimating the Fraction of Severe Malaria among Malaria-Positive Children: Analysis of Household Surveys in 19 Malaria-Endemic Countries in Africa","volume":"104","author":"Taylor","year":"2021","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mandala, W.L., Ward, S., Taylor, T.E., and Wassmer, S.C. (2022). Characterization of Lymphocyte Subsets in Lymph Node and Spleen Sections in Fatal Pediatric Malaria. Pathogens, 11.","DOI":"10.3390\/pathogens11080851"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Mota, S., Bensalel, J., Park, D.H., Gonzalez, S., Rodriguez, A., and Gallego-Delgado, J. (2022). Treatment Reducing Endothelial Activation Protects against Experimental Cerebral Malaria. Pathogens, 11.","DOI":"10.3390\/pathogens11060643"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Tunon-Ortiz, A., and Lamb, T.J. (2019). Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007786"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"ofw046","DOI":"10.1093\/ofid\/ofw046","article-title":"Acute Kidney Injury Is Common in Pediatric Severe Malaria and Is Associated with Increased Mortality","volume":"3","author":"Conroy","year":"2016","journal-title":"Open Forum Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Hawkes, M.T., Leligdowicz, A., Batte, A., Situma, G., Zhong, K., Namasopo, S., Opoka, R.O., Kain, K.C., and Conroy, A.L. (2022). Pathophysiology of Acute Kidney Injury in Malaria and Non-Malarial Febrile Illness: A Prospective Cohort Study. Pathogens, 11.","DOI":"10.3390\/pathogens11040436"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s42826-022-00128-1","article-title":"Role of animal models in biomedical research: A review","volume":"38","author":"Mukherjee","year":"2022","journal-title":"Lab. Anim. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bensalel, J., Roberts, A., Hernandez, K., Pina, A., Prempeh, W., Babalola, B.V., Cannata, P., Lazaro, A., and Gallego-Delgado, J. (2023). Novel Experimental Mouse Model to Study Malaria-Associated Acute Kidney Injury. Pathogens, 12.","DOI":"10.3390\/pathogens12040545"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2150456","DOI":"10.1080\/21505594.2022.2150456","article-title":"Pathogenicity and virulence of malaria: Sticky problems and tricky solutions","volume":"14","author":"Walker","year":"2023","journal-title":"Virulence"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Carmona-Fonseca, J., Olivera, M.J., and Yasnot-Acosta, M.F. (2022). A Retrospective Review on Severe Malaria in Colombia, 2007\u20132020. Pathogens, 11.","DOI":"10.3390\/pathogens11080893"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Garrido-Cardenas, J.A., Gonzalez-Ceron, L., Garcia-Maroto, F., Cebrian-Carmona, J., Manzano-Agugliaro, F., and Mesa-Valle, C.M. (2023). Analysis of Fifty Years of Severe Malaria Worldwide Research. Pathogens, 12.","DOI":"10.3390\/pathogens12030373"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0140-6736(21)01207-1","article-title":"Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: All-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019","volume":"398","author":"Collaborators","year":"2021","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1186\/s12936-020-03430-2","article-title":"Researchers\u2019 perceptions of malaria eradication: Findings from a mixed-methods analysis of a large online survey","volume":"19","author":"Brew","year":"2020","journal-title":"Malar. J."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/12\/12\/1389\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:29:57Z","timestamp":1760131797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/12\/12\/1389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,25]]},"references-count":14,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["pathogens12121389"],"URL":"https:\/\/doi.org\/10.3390\/pathogens12121389","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,25]]}}}