{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:12:06Z","timestamp":1784639526570,"version":"3.55.0"},"reference-count":70,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","doi-asserted-by":"publisher","award":["2010525423"],"award-info":[{"award-number":["2010525423"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>We investigated the zoonotic transmission of Cryptosporidium among the children (n = 188), dogs (n = 133), and cats (n = 55) living in 188 households. Fecal samples were examined using ELISA and confirmed via nested PCR. Coproantigens oocysts were detected in 3.7% of children, 8.3% of dogs, and 5.5% of cats. We found strong evidence of two cases of the zoonotic transmission of Cryptosporidium canis between children and dogs. Furthermore, four children and their respective pets (one dog and three cats) were infected with Cryptosporidium parvum, but we cannot exclude the hypotheses that the oocysts were transmitted from children to animals or that both hosts were infected by a shared source, such as contaminated water or food. The presence of an infected animal elevated the risk of zoonotic transmission by 129.7-fold (95% CI: 13.92\u20131209.68). Furthermore, sharing a bed with pets was identified as a risk factor for infection in children (OR: 9.9, 95% CI: 1.37\u201371.2). In conclusion, the zoonotic transmission of Cryptosporidium among children and pets cohabiting in the same household may be quite common, especially when infected animals lie or sleep on children\u2019s beds. These findings unequivocally highlight the public health concern surrounding C. canis.<\/jats:p>","DOI":"10.3390\/pathogens12121393","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T11:54:48Z","timestamp":1701086088000},"page":"1393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evidence of the Zoonotic Transmission of Cryptosporidium among Children and Pets"],"prefix":"10.3390","volume":"12","author":[{"given":"Natalia Marinho Dourado","family":"Coelho","sequence":"first","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria, Universidade Estadual Paulista (Unesp), Ara\u00e7atuba 16050-680, S\u00e3o Paulo, Brazil"},{"name":"Faculdade de Ci\u00eancias Agr\u00e1rias, Funda\u00e7\u00e3o Educacional de Andradina, Andradina 16901-160, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willian Marinho Dourado","family":"Coelho","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Agr\u00e1rias, Funda\u00e7\u00e3o Educacional de Andradina, Andradina 16901-160, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jancarlo Ferreira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas e Instituto de Computa\u00e7\u00e3o, Universidade Estadual de Campinas (UNICAMP), Campinas 13083-887, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0063-5172","authenticated-orcid":false,"given":"Marcelo Vasconcelos","family":"Meireles","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria, Universidade Estadual Paulista (Unesp), Ara\u00e7atuba 16050-680, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5444-6695","authenticated-orcid":false,"given":"Walter Bertequini","family":"Nagata","sequence":"additional","affiliation":[{"name":"Escrit\u00f3rio de Defesa Agropecu\u00e1ria, Coordenadoria de Defesa Agropecu\u00e1ria, Secretaria de Agricultura e Abastecimento do Estado de S\u00e3o Paulo, Lins 16400-050, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0954-5045","authenticated-orcid":false,"given":"Val\u00e9ria Mar\u00e7al Felix","family":"de Lima","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria, Universidade Estadual Paulista (Unesp), Ara\u00e7atuba 16050-680, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8300-0473","authenticated-orcid":false,"given":"Thais Rabelo","family":"Santos-Doni","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Agr\u00e1rias, Universidade Federal do Vale do Jequitinhonha e Mucuri (UFVJM), Una\u00ed 38610-000, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vit\u00f3ria Beatriz","family":"Silva","sequence":"additional","affiliation":[{"name":"Imunologia e Vacinologia, Curso de Engenharia de Bioprocessos e Biotecnologia, Universidade Federal do Tocantins (UFT), Gurupi 77410-530, Tocantins, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9279-9571","authenticated-orcid":false,"given":"Luiz","family":"da Silveira Neto","sequence":"additional","affiliation":[{"name":"Imunologia e Vacinologia, Curso de Engenharia de Bioprocessos e Biotecnologia, Universidade Federal do Tocantins (UFT), Gurupi 77410-530, Tocantins, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5114-3234","authenticated-orcid":false,"given":"Alex Akira","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria, Universidade Estadual Paulista (Unesp), Ara\u00e7atuba 16050-680, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia Denise Saraiva","family":"Bresciani","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria, Universidade Estadual Paulista (Unesp), Ara\u00e7atuba 16050-680, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/pim.12350","article-title":"Cryptosporidium in Humans and Animals\u2014A One Health Approach to Prophylaxis","volume":"38","author":"Ryan","year":"2016","journal-title":"Parasite Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"D\u0103r\u0103bu\u0219, G., Lupu, M.A., Mederle, N., D\u0103r\u0103bu\u0219, R.G., Imre, K., Mederle, O., Imre, M., Paduraru, A.A., Morariu, S., and Olariu, T.R. 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