{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:47:17Z","timestamp":1792806437763,"version":"4.5.0"},"reference-count":101,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Buenos Aires","award":["20020220100012BA"],"award-info":[{"award-number":["20020220100012BA"]}],"id":[{"id":"https:\/\/ror.org\/0081fs513","id-type":"ROR","asserted-by":"crossref"}]},{"name":"University of Buenos Aires","award":["PICT-2021-I-A-00680"],"award-info":[{"award-number":["PICT-2021-I-A-00680"]}],"id":[{"id":"https:\/\/ror.org\/0081fs513","id-type":"ROR","asserted-by":"crossref"}]},{"name":"FONCYT","award":["20020220100012BA"],"award-info":[{"award-number":["20020220100012BA"]}]},{"name":"FONCYT","award":["PICT-2021-I-A-00680"],"award-info":[{"award-number":["PICT-2021-I-A-00680"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Infection by Brucella species in pregnant animals and humans is associated with an increased risk of abortion, preterm birth, and transmission of the infection to the offspring. The pathogen has a marked tropism for the placenta and the pregnant uterus and has the ability to invade and replicate within cells of the maternal\u2013fetal unit, including trophoblasts and decidual cells. Placentitis is a common finding in infected pregnant animals. Several proinflammatory factors have been found to be increased in both the placenta of Brucella-infected animals and in trophoblasts or decidual cells infected in vitro. As normal pregnancies require an anti-inflammatory placental environment during most of the gestational period, Brucella-induced placentitis is thought to be associated with the obstetric complications of brucellosis. A few studies suggest that the blockade of proinflammatory factors may prevent abortion in these cases.<\/jats:p>","DOI":"10.3390\/pathogens12121450","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T03:16:33Z","timestamp":1702610193000},"page":"1450","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Immune Responses Potentially Involved in the Gestational Complications of Brucella Infection"],"prefix":"10.3390","volume":"12","author":[{"given":"Luc\u00eda","family":"Zavattieri","sequence":"first","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires 1113, Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Universidad de Buenos Aires, Buenos Aires 1113, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2129-8278","authenticated-orcid":false,"given":"Florencia","family":"Mu\u00f1oz Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires 1113, Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Universidad de Buenos Aires, Buenos Aires 1113, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-4116","authenticated-orcid":false,"given":"Mariana C.","family":"Ferrero","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires 1113, Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Universidad de Buenos Aires, Buenos Aires 1113, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2500-6682","authenticated-orcid":false,"given":"Pablo C.","family":"Baldi","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires 1113, Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Universidad de Buenos Aires, Buenos Aires 1113, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1473-3099(06)70382-6","article-title":"The New Global Map of Human Brucellosis","volume":"6","author":"Pappas","year":"2006","journal-title":"Lancet Infect. 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