{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:39:53Z","timestamp":1760143193593,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R24AI152598-01"],"award-info":[{"award-number":["1R24AI152598-01"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The high proportion of people with HIV (PWH) in the 2022\u20132023 mpox outbreak has raised questions surrounding the association between HIV and mpox. The objectives of this study were to evaluate the association between engagement in HIV-associated healthcare and mpox diagnosis, as well as to characterize cases of mpox among PWH. The DC Cohort is a longitudinal cohort of PWH in Washington, DC. We conducted a 5:1 (controls:cases) nested case-cohort study on male participants, matching age and care site. Cases were participants with an identified mpox diagnosis. Conditional logistic regression was used to assess the impact of indicators of engagement in HIV-associated healthcare on mpox diagnosis. We identified 70 cases of mpox in DC Cohort participants randomly matched to 323 controls, for a total of 393 participants included in the analysis. Study participants were primarily non-Hispanic Black (72.3%) with a median age of 41 (IQR: 36, 50). There was no association between engagement in care and mpox diagnosis; however, low CD4 was associated with increased odds of mpox diagnosis (aOR: 4.60 (95% CI: 1.23, 17.11)). Among a cohort of PWH, engagement in care was not associated with mpox diagnosis, suggesting that the overrepresentation of PWH among mpox cases is not due to surveillance bias.<\/jats:p>","DOI":"10.3390\/pathogens13020117","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:57:07Z","timestamp":1706504227000},"page":"117","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterizing Indicators of Engagement in HIV-Associated Healthcare and Clinical Outcomes among People with HIV and Mpox in Washington, DC: A Nested Case-Control Study of the DC Cohort"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9205-0544","authenticated-orcid":false,"given":"Lauren F.","family":"O\u2019Connor","sequence":"first","affiliation":[{"name":"Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Byrne","sequence":"additional","affiliation":[{"name":"Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuja","family":"Baskaran","sequence":"additional","affiliation":[{"name":"Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth W.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6971-7646","authenticated-orcid":false,"given":"Michael A.","family":"Horberg","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Mid-Atlantic Permanente Medical Group, Rockville, MD 20852, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra A.","family":"Benator","sequence":"additional","affiliation":[{"name":"District of Columbia Veterans Affairs Medical Center, Washington, DC 20422, USA"},{"name":"School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Lucar","sequence":"additional","affiliation":[{"name":"School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-1774","authenticated-orcid":false,"given":"Rachel V.","family":"Denyer","sequence":"additional","affiliation":[{"name":"District of Columbia Veterans Affairs Medical Center, Washington, DC 20422, USA"},{"name":"School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Lee","sequence":"additional","affiliation":[{"name":"District of Columbia Veterans Affairs Medical Center, Washington, DC 20422, USA"},{"name":"School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9095-2413","authenticated-orcid":false,"given":"Amanda D.","family":"Castel","sequence":"additional","affiliation":[{"name":"Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-3845","authenticated-orcid":false,"given":"Anne K.","family":"Monroe","sequence":"additional","affiliation":[{"name":"Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"ref_1","unstructured":"(2023, May 25). 2022 Outbreak Cases and Data|Mpox|Poxvirus|CDC. Published 17 May 2023, Available online: https:\/\/www.cdc.gov\/poxvirus\/mpox\/response\/2022\/index.html."},{"key":"ref_2","unstructured":"(2022, December 20). Mpox Data|Doh, Available online: https:\/\/dchealth.dc.gov\/node\/1611066."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.15585\/mmwr.mm7132e3","article-title":"Epidemiologic and Clinical Characteristics of Monkeypox Cases\u2014United States, 17 May\u201322 July 2022","volume":"71","author":"Philpott","year":"2022","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0140-6736(23)00273-8","article-title":"Mpox in people with advanced HIV infection: A global case series","volume":"401","author":"Alemany","year":"2023","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1093\/cid\/ciad052","article-title":"Severe Mpox Infections in People With Uncontrolled Human Immunodeficiency Virus","volume":"76","author":"Govind","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.15585\/mmwr.mm7136a1","article-title":"HIV and Sexually Transmitted Infections Among Persons with Monkeypox\u2014Eight U.S. Jurisdictions, 17 May\u201322 July 2022","volume":"71","author":"Curran","year":"2022","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0140-6736(23)00395-1","article-title":"The emergence of mpox as an HIV-related opportunistic infection","volume":"401","author":"Daskalakis","year":"2023","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"642","DOI":"10.7326\/M22-3132","article-title":"Tecovirimat Treatment of People With HIV During the 2022 Mpox Outbreak: A Retrospective Cohort Study","volume":"176","author":"McLean","year":"2023","journal-title":"Ann. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e26043","DOI":"10.1002\/jia2.26043","article-title":"Intersecting HIV and mpox epidemics: More questions than answers","volume":"25","author":"Girometti","year":"2022","journal-title":"J. Int. AIDS Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1093\/cid\/ciac962","article-title":"Is Mpox a Sexually Transmitted Infection? Why Narrowing the Scope of This Disease May Be Harmful","volume":"76","author":"Hazra","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Sah, R., Abdelaal, A., Reda, A., Katamesh, B.E., Manirambona, E., Abdelmonem, H., Mehta, R., Rabaan, A.A., Alhumaid, S., and Alfouzan, W.A. (2022). Monkeypox and Its Possible Sexual Transmission: Where Are We Now with Its Evidence?. Pathogens, 11.","DOI":"10.20944\/preprints202207.0314.v1"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.15585\/mmwr.mm7135e2","article-title":"Modeling the Impact of Sexual Networks in the Transmission of Monkeypox virus Among Gay, Bisexual, and Other Men Who Have Sex With Men\u2014United States, 2022","volume":"71","author":"Spicknall","year":"2022","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S1473-3099(22)00411-X","article-title":"Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London, UK: An observational analysis","volume":"22","author":"Girometti","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_14","unstructured":"(2023, May 25). 2021 Annual Surveillance Report_Final_3.29.pdf, Available online: https:\/\/dchealth.dc.gov\/sites\/default\/files\/dc\/sites\/doh\/publication\/attachments\/2021%20Annual%20Surveillance%20Report_final_3.29.pdf."},{"key":"ref_15","unstructured":"(2023, May 25). Signs and Symptoms|Mpox|Poxvirus|CDC, Available online: https:\/\/www.cdc.gov\/poxvirus\/mpox\/symptoms\/index.html."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Liu, Q., Fu, L., Wang, B., Sun, Y., Wu, X., Peng, X., Li, Y., Lin, Y.-F., Fitzpatrick, T., and Vermund, S.H. (2023). Clinical Characteristics of Human Mpox (Monkeypox) in 2022: A Systematic Review and Meta-Analysis. Pathogens, 12.","DOI":"10.3390\/pathogens12010146"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s10461-021-03468-6","article-title":"Infrequent STI Testing in New York City Among High Risk Sexual and Gender Minority Individuals Interested In Self- and Partner-Testing","volume":"26","author":"Kutner","year":"2022","journal-title":"AIDS Behav."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/jamia\/ocv176","article-title":"Development of a large urban longitudinal HIV clinical cohort using a web-based platform to merge electronically and manually abstracted data from disparate medical record systems: Technical challenges and innovative solutions","volume":"23","author":"Greenberg","year":"2016","journal-title":"J. Am. Med. Inform. Assoc. JAMIA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e16061","DOI":"10.2196\/16061","article-title":"Comparison of Clinical Outcomes of Persons Living With HIV by Enrollment Status in Washington, DC: Evaluation of a Large Longitudinal HIV Cohort Study","volume":"6","author":"Opoku","year":"2020","journal-title":"JMIR Public Health Surveill."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.15585\/mmwr.mm7144e1","article-title":"Severe Monkeypox in Hospitalized Patients\u2014United States, 10 August\u201310 October 2022","volume":"71","author":"Miller","year":"2022","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Alshahrani, A.M. (2022). Cost\u2013Benefit Analysis of Interventions to Mitigate the Monkeypox Virus. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192113789"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e27913","DOI":"10.1002\/jmv.27913","article-title":"Attaching a stigma to the LGBTQI+ community should be avoided during the monkeypox epidemic","volume":"95","author":"Bragazzi","year":"2023","journal-title":"J. Med. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e29091","DOI":"10.1002\/jmv.29091","article-title":"Mpox stigma among men who have sex with men in the Netherlands: Underlying beliefs and comparisons across other commonly stigmatized infections","volume":"95","author":"Zimmermann","year":"2023","journal-title":"J. Med. Virol."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/13\/2\/117\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:50:20Z","timestamp":1760104220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/13\/2\/117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,27]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["pathogens13020117"],"URL":"https:\/\/doi.org\/10.3390\/pathogens13020117","relation":{},"ISSN":["2076-0817"],"issn-type":[{"type":"electronic","value":"2076-0817"}],"subject":[],"published":{"date-parts":[[2024,1,27]]}}}