{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:41:28Z","timestamp":1782996088307,"version":"3.54.5"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The Global Polio Eradication Initiative made immense progress after its establishment in 1988 as a consequence of high coverage with various poliovirus vaccines in all populations of the world. Problems have arisen in recent years, however, related to security issues in some countries, to the circulation of vaccine-derived polioviruses, and to the recognition that individuals with certain immune deficiencies can remain infected and infectious for many months or years. As natural infection and different vaccines have different effects on the immune system, the patterns of humoral and mucosal immunity to polioviruses in the world today are complex but are crucial to the ultimate success of the eradication initiative. This paper describes the background of the current situation and current immunological patterns and discusses their implications for managing population immunity to polioviruses in the years ahead.<\/jats:p>","DOI":"10.3390\/pathogens13030183","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T04:04:14Z","timestamp":1708401854000},"page":"183","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Population Immunity and Polio Eradication"],"prefix":"10.3390","volume":"13","author":[{"given":"Paul E. M.","family":"Fine","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine, Keppel St., London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Is polio eradication in the Americas economically justified?","volume":"22","author":"Musgrove","year":"1988","journal-title":"Bull. Pan Am. Health Organ."},{"key":"ref_2","first-page":"35","article-title":"Global eradication of poliomyelitis: Benefit-cost analysis","volume":"74","author":"Bart","year":"1996","journal-title":"Bull. World Health Organ."},{"key":"ref_3","unstructured":"Orenstein, W.A., Offit, P.A., Edwards, K.M., and Plotkin, S.A. (2024). Vaccines, Elsevier Inc.. [8th ed.]. 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