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Tecnol\u00f3gico (CNPq)","award":["U01 AI151698"],"award-info":[{"award-number":["U01 AI151698"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["CRP\/BRA20-03"],"award-info":[{"award-number":["CRP\/BRA20-03"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["151235\/2023-6"],"award-info":[{"award-number":["151235\/2023-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>This report provides a detailed overview of the resurgence of DENV-3 in the state of Minas Gerais, Brazil, which is a concerning scenario in the context of dengue, a mosquito-borne viral disease. Historically, Brazil has grappled with dengue epidemics caused primarily by the DENV-1 and DENV-2 serotypes. However, in 2023, a significant shift in this pattern was observed as DENV-3 made a notable resurgence. This resurgence was characterized by the increase in DENV-3 cases within the country and the region of the Americas. Given the absence of sustained DENV-3 circulation in Brazil in previous years, this situation poses a significant risk, making the population highly susceptible to a potential novel epidemic. In November 2023, a 31-year-old male patient in Belo Horizonte exhibited symptoms of acute febrile syndrome. Multiplex RT-qPCR using the Kit Molecular ZC D-Tipagem confirmed DENV-3 infection, suggesting a likely autochthonous case, as the patient reported no travel history. To promptly assess this resurgence, we applied the nanopore sequencing technology. This allowed for the rapid characterization of the initial DENV-3 case isolated in Minas Gerais in 2023, representing a 13-year interval since the serotype\u2019s previous documented circulation in that state. This case report underscores the critical importance of proactive monitoring and the swift implementation of targeted control strategies to address the evolving dynamics of dengue, with a specific emphasis on the resurgence of DENV-3 in the state.<\/jats:p>","DOI":"10.3390\/pathogens13030202","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T06:50:23Z","timestamp":1708930223000},"page":"202","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Resurgence of Dengue Virus Serotype 3 in Minas Gerais, Brazil: A Case Report"],"prefix":"10.3390","volume":"13","author":[{"given":"Talita","family":"Adelino","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte 30510-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio","family":"Lima","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte 30510-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9859-5895","authenticated-orcid":false,"given":"Nat\u00e1lia R.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte 30510-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joilson","family":"Xavier","sequence":"additional","affiliation":[{"name":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Belo Horizonte 30190-009, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-6448","authenticated-orcid":false,"given":"Vagner","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Exact and Earth Science, University of the State of Bahia, Salvador 41192-010, Brazil"},{"name":"Climate Amplified Diseases and Epidemics (CLIMADE), Brasilia 70070-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-5558","authenticated-orcid":false,"given":"Luiz Marcelo R.","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte 30510-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira Alves","family":"Pereira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte 30510-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Ferreira","family":"Machado","sequence":"additional","affiliation":[{"name":"Secretaria Municipal de Sa\u00fade de Belo Horizonte, Belo Horizonte 30130-012, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-9931","authenticated-orcid":false,"given":"Luiz Carlos Junior","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Belo Horizonte 30190-009, Brazil"},{"name":"Climate Amplified Diseases and Epidemics (CLIMADE), Brasilia 70070-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe C. de Melo","family":"Iani","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte 30510-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-7326","authenticated-orcid":false,"given":"Marta","family":"Giovanetti","sequence":"additional","affiliation":[{"name":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Belo Horizonte 30190-009, Brazil"},{"name":"Climate Amplified Diseases and Epidemics (CLIMADE), Brasilia 70070-130, Brazil"},{"name":"Sciences and Technologies for Sustainable Development and One Health, Universit\u00e0 Campus Bio-Medico di Roma, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s00705-023-05835-1","article-title":"Renaming of the genus Flavivirus to Orthoflavivirus and extension of binomial species names within the family Flaviviridae","volume":"168","author":"Postler","year":"2023","journal-title":"Arch. 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