{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:25:18Z","timestamp":1791325518140,"version":"4.3.1"},"reference-count":85,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias, y Tecnolog\u00edas (CONAHCYT)","doi-asserted-by":"publisher","award":["PN-2017-01-5254"],"award-info":[{"award-number":["PN-2017-01-5254"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa de Fortalecimiento de Institutos, Centros, y Laboratorios de Investigaci\u00f3n 2021, Universidad de Guadalajara","award":["PN-2017-01-5254"],"award-info":[{"award-number":["PN-2017-01-5254"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The complex epidemiology of hepatitis C virus (HCV) infection among human immunodeficiency virus (HIV) patients in West Mexico remains poorly understood. Thus, this study aimed to investigate the HCV prevalence, HCV-associated risk factors, and HCV genotypes\/subtypes and assess their impacts on liver fibrosis in 294 HIV patients (median age: 38 years; 88.1% male). HCV RNA was extracted and amplified by PCR. Hepatic fibrosis was assessed using three noninvasive methods: transient elastography (TE), the aspartate aminotransferase (AST)-to-platelets ratio index score (APRI), and the fibrosis-4 score (FIB4). Patients with liver stiffness of \u22659.3 Kpa were considered to have advanced liver fibrosis. HCV genotypes\/subtypes were determined by line probe assay (LiPA) or Sanger sequencing. The prevalence of HIV\/HCV infection was 36.4% and was associated with injection drug use (odds ratio (OR) = 13.2; 95% confidence interval (CI) = 5.9\u201333.6; p &lt; 0.001), imprisonment (OR = 3.0; 95% CI = 1.7\u20135.4; p &lt; 0.001), the onset of sexual life (OR = 2.6; 95% CI = 1.5\u20134.5; p &lt; 0.001), blood transfusion (OR = 2.5; 95% CI = 1.5\u20134.2; p = 0.001), tattooing (OR = 2.4; 95% CI = 1.4\u20133.9; p = 0.001), being a sex worker (OR = 2.3; 95% CI = 1.0\u20135.4; p = 0.046), and surgery (OR = 1.7; 95% CI = 1.0\u20132.7; p = 0.042). The HCV subtype distribution was 68.2% for 1a, 15.2% for 3a, 10.6% for 1b, 3.0% for 2b, 1.5% for 2a, and 1.5% for 4a. The advanced liver fibrosis prevalence was highest in patients with HIV\/HCV co-infection (47.7%), especially in those with HCV subtype 1a. CD4+ counts, albumin, direct bilirubin, and indirect bilirubin were associated with liver fibrosis. In conclusion, HCV infection had a significant impact on the liver health of Mexican HIV patients, highlighting the need for targeted preventive strategies in this population.<\/jats:p>","DOI":"10.3390\/pathogens13050360","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T10:33:36Z","timestamp":1714386816000},"page":"360","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Epidemiology of Hepatitis C Virus in HIV Patients from West Mexico: Implications for Controlling and Preventing Viral Hepatitis"],"prefix":"10.3390","volume":"13","author":[{"given":"Alexis","family":"Jose-Abrego","sequence":"first","affiliation":[{"name":"Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Guadalajara 44280, Jalisco, Mexico"},{"name":"Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Trujillo-Trujillo","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Guadalajara 44280, Jalisco, Mexico"},{"name":"Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-0920","authenticated-orcid":false,"given":"Saul","family":"Laguna-Meraz","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Guadalajara 44280, Jalisco, Mexico"},{"name":"Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Guadalajara 44280, Jalisco, Mexico"},{"name":"Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Panduro","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, \u201cFray Antonio Alcalde\u201d, Guadalajara 44280, Jalisco, Mexico"},{"name":"Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2023, December 04). 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