{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:24:55Z","timestamp":1784543095537,"version":"3.55.0"},"reference-count":80,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The drivers of the HIV epidemic, the viruses, the opportunistic infections, the attitudes and the resources allocated to the fight against HIV\/AIDS, vary substantially across countries. French Guiana, at the crossroads between Amazonian South America and the Caribbean, constitutes a singular context with poor populations and rich country health funding, which has allowed researchers to gather lots of information on the particulars of our epidemic. We aimed to focus on the little known story of forty years of HIV research in French Guiana and emphasize how local research intertwined with public health action has yielded continuous progress, despite the difficult social conditions of the affected population. We searched Web of Science and associated local experts who worked through much of the epidemic in selecting the most meaningful products of local research for clinical and public health outcomes in French Guiana. Research tools and facilities included, from 1991 onwards, the HIV hospital cohort and the HIV-histoplasmosis cohort. Ad hoc studies funded by the ANRS or the European Regional Development fund shed light on vulnerable groups. The cumulative impact of prospective routine collection and focused efforts has yielded a breadth of knowledge, allowing for informed decisions and the adaptation of prevention, testing and care in French Guiana. After this overview, we emphasize that the close integration of research and public health was crucial in adapting interventions to the singular context of French Guiana.<\/jats:p>","DOI":"10.3390\/pathogens13060459","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T05:19:49Z","timestamp":1716873589000},"page":"459","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Forty Years of HIV Research in French Guiana: Comprehend to Combat"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9397-3204","authenticated-orcid":false,"given":"Mathieu","family":"Nacher","sequence":"first","affiliation":[{"name":"Comit\u00e9 de Coordination R\u00e9gionale de la Lutte contre le VIH et les IST, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"},{"name":"Centre d\u2019Investigation Clinique INSERM 1424, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"},{"name":"D\u00e9partement Formation Recherche en Sant\u00e9, Universit\u00e9 de Guyane, 97300 Cayenne, French Guiana"},{"name":"Institut Sant\u00e9 des Populations en Amazonie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Lucarelli","sequence":"additional","affiliation":[{"name":"Comit\u00e9 de Coordination R\u00e9gionale de la Lutte contre le VIH et les IST, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Van-Melle","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique INSERM 1424, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Basurko","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique INSERM 1424, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Rabier","sequence":"additional","affiliation":[{"name":"Comit\u00e9 de Coordination R\u00e9gionale de la Lutte contre le VIH et les IST, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malorie","family":"Chroum","sequence":"additional","affiliation":[{"name":"Comit\u00e9 de Coordination R\u00e9gionale de la Lutte contre le VIH et les IST, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Santana","sequence":"additional","affiliation":[{"name":"Comit\u00e9 de Coordination R\u00e9gionale de la Lutte contre le VIH et les IST, Centre Hospitalier de Cayenne, 97300 Cayenne, French 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Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hawa","family":"Cisse","sequence":"additional","affiliation":[{"name":"H\u00f4pital de Jour Adultes, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Epelboin","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Le Turnier","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Abboud","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, Centre Hospitalier de Cayenne, 97300 Cayenne, French 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Guiana"},{"name":"D\u00e9partement Formation Recherche en Sant\u00e9, Universit\u00e9 de Guyane, 97300 Cayenne, French Guiana"},{"name":"Institut Sant\u00e9 des Populations en Amazonie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Couppi\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9partement Formation Recherche en Sant\u00e9, Universit\u00e9 de Guyane, 97300 Cayenne, French Guiana"},{"name":"Institut Sant\u00e9 des Populations en Amazonie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"},{"name":"Service de Dermatologie V\u00e9n\u00e9r\u00e9ologie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"ref_1","unstructured":"(2024, March 30). 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