{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T11:56:06Z","timestamp":1793620566017,"version":"4.5.0"},"reference-count":161,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Advances in pediatric TB care are promising, the result of decades of advocacy, operational and clinical trials research, and political will by national and local TB programs in high-burden countries. However, implementation challenges remain in linking policy to practice and scaling up innovations for prevention, diagnosis, and treatment of TB in children, especially in resource-limited settings. There is both need and opportunity to strengthen clinician confidence in making a TB diagnosis and managing the various manifestations of TB in children, which can facilitate the translation of evidence to action and expand access to new tools and strategies to address TB in this population. This review aims to summarize existing guidance and best practices for clinicians and health care providers in low-resource, TB-endemic settings and identify resources with more detailed and actionable information for decision-making along the clinical cascade to prevent, find, and cure TB in children.<\/jats:p>","DOI":"10.3390\/pathogens13060467","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T08:19:42Z","timestamp":1717402782000},"page":"467","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Pediatric Tuberculosis: A Review of Evidence-Based Best Practices for Clinicians and Health Care Providers"],"prefix":"10.3390","volume":"13","author":[{"given":"Brittany K.","family":"Moore","sequence":"first","affiliation":[{"name":"Division of Global HIV and Tuberculosis, U.S. Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-2294","authenticated-orcid":false,"given":"Stephen M.","family":"Graham","sequence":"additional","affiliation":[{"name":"Centre for International Child Health, Department of Pediatrics, University of Melbourne, Melbourne 3052, Australia"},{"name":"Murdoch Children\u2019s Research Institute, Royal Children\u2019s Hospital, Melbourne 3052, Australia"},{"name":"International Union Against Tuberculosis and Lung Disease, 75001 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhadra","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis, U.S. Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Doyle","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis, U.S. Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3114-0159","authenticated-orcid":false,"given":"Susan A.","family":"Maloney","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis, U.S. Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,1]]},"reference":[{"key":"ref_1","unstructured":"WHO (2022). 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