{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:55:21Z","timestamp":1784811321639,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Poznan University of Medical Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>This study investigates the impact of Epstein\u2013Barr virus (EBV) infection on children\u2019s proteomes across different phases of the disease, utilising seventy-nine blood samples categorised into three groups: EBV-naive patients, acute infectious mononucleosis (IM) cases, and convalescents followed up for 12 months post-IM. The aim is to identify proteins influenced by EBV infection, shedding light on the chronic processes triggered by the virus. The results reveal thirty-nine proteins distinguishing between naive patients and those with IM, including actin, lumican, peroxiredoxin-2, fibulin-1, gelsolin, and alpha-2-macroglobulin, which are involved in immune responses, cell adhesion, and inflammation. Elevated oxidative stress markers like peroxiredoxin-2 in IM patients suggest potential links to EBV\u2019s induction of reactive oxygen species. Increased levels of apolipoproteins A-I, A-IV, C-IV, and M during IM imply associations with viral infection, while complement system proteins (C1q, C1r, and C8 gamma chain) are also elevated, reflecting their role in the immune response and viral clearance. This study\u2019s focus on children provides unique insights into EBV\u2019s impact on young populations, emphasising proteomics\u2019 role in uncovering protein associations and understanding the virus\u2019s long-term consequences. However, specific relationships between identified proteins and EBV infection require further investigation.<\/jats:p>","DOI":"10.3390\/pathogens13060471","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T08:43:54Z","timestamp":1717577034000},"page":"471","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Acute EBV Infection on Changes in the Serum Proteome in Children\u2014A Pilot Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2695-4649","authenticated-orcid":false,"given":"Katarzyna","family":"Mazur-Melewska","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, 60-572 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2182-5699","authenticated-orcid":false,"given":"Magdalena","family":"Luczak","sequence":"additional","affiliation":[{"name":"Department of Biomedical Proteomics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0962-5114","authenticated-orcid":false,"given":"Joanna","family":"Watral","sequence":"additional","affiliation":[{"name":"Department of Biomedical Proteomics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0651-4454","authenticated-orcid":false,"given":"Pawe\u0142","family":"Ma\u0142ecki","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, 60-572 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-2560","authenticated-orcid":false,"given":"Anna","family":"Mania","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, 60-572 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-0658","authenticated-orcid":false,"given":"Magdalena","family":"Figlerowicz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, 60-572 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1177\/0883073815613563","article-title":"Neurologic Complications Caused by Epstein-Barr Virus in Pediatric Patients","volume":"31","author":"Kemnitz","year":"2016","journal-title":"J. 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