{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:39:37Z","timestamp":1779208777660,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2021R1A2C2005385"],"award-info":[{"award-number":["NRF-2021R1A2C2005385"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>(1) Background: Peptides are appealing as pharmacological materials because they are easily produced, safe, and tolerable. Despite increasing gum-care awareness, periodontitis is still prevalent and is influenced by factors like high sugar consumption, smoking, and aging. Porphyromonas gingivalis is considered a major etiologic agent of periodontitis and activates the NLR family pyrin domain containing 3 (NLRP3) but is absent in melanoma 2 (AIM2) inflammasomes, resulting in pro-inflammatory cytokine release. (2) Methods: We examined the anti-inflammatory effects of 18 peptides derived from human stromal cell-derived factor-1 (SDF-1) on THP-1 macrophages. Inflammation was induced by P. gingivalis, and the anti-inflammatory effects were analyzed using molecular biological techniques. In a mouse periodontitis model, alveolar bone resorption was assessed using micro-CT. (3) Results: Of the 18 SDF-1-derived peptides, S10 notably reduced IL-1\u03b2 and TNF-\u03b1 secretion. S10 also diminished the P. gingivalis-induced expression of NLRP3, AIM2, ASC (apoptosis-associated speck-like protein), caspase-1, and IL-1\u03b2. Furthermore, S10 attenuated the enhanced TLR (toll-like receptor) signaling pathway and decreased the phosphorylation of nuclear factor-\u03baB (NF-\u03baB) and mitogen-activated protein kinases (MAPKs). In addition, S10 mitigated alveolar bone loss in our P. gingivalis-induced mouse model of periodontitis. (4) Conclusions: S10 suppressed TLR\/NF-\u03baB\/NLRP3 inflammasome signaling and the AIM2 inflammasome in our P. gingivalis-induced murine periodontitis model, which suggests that it has potential use as a therapeutic treatment for periodontitis.<\/jats:p>","DOI":"10.3390\/pathogens13060474","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T11:48:50Z","timestamp":1717501730000},"page":"474","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Anti-Inflammatory Effect of SDF-1 Derived Peptide on Porphyromonas gingivalis Infection via Regulation of NLRP3 and AIM2 Inflammasome"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-8115","authenticated-orcid":false,"given":"Si Yeong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea"},{"name":"Oral Genomics Research Center, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9653-9689","authenticated-orcid":false,"given":"Min Kee","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hwa","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea"},{"name":"Oral Genomics Research Center, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3246-4681","authenticated-orcid":false,"given":"Hee Sam","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea"},{"name":"Oral Genomics Research Center, Pusan National University, Yangsan 50612, Republic of Korea"},{"name":"BK21 PLUS Project, Dental Research Institute, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6859-615X","authenticated-orcid":false,"given":"Jin","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea"},{"name":"Oral Genomics Research Center, Pusan National University, Yangsan 50612, Republic of Korea"},{"name":"BK21 PLUS Project, Dental Research Institute, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-0757.2009.00326.x","article-title":"Epidemiologic patterns of chronic and aggressive periodontitis","volume":"53","author":"Demmer","year":"2010","journal-title":"Periodontol. 2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-0757.2011.00397.x","article-title":"Principles of periodontology","volume":"61","author":"Dentino","year":"2013","journal-title":"Periodontol. 2000"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"How, K.Y., Song, K.P., and Chan, K.G. 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