{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:11:26Z","timestamp":1760145086395,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Merck Animal Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The efficacy of an intranasal (IN) bovine respiratory syncytial virus (BRSV) vaccine administered in the presence of passive immunity was assessed. Pooled colostrum was administered by intubation to 50 beef-dairy crossbred calves the day they were born. The calves were transported to a research facility and were blocked by age and sex, and randomly assigned into two groups: sham-vaccinated intranasally with a placebo (sterile water) or vaccinated with a trivalent (BRSV, bovine herpesvirus 1 and bovine parainfluenza 3) modified live viral (MLV) vaccine. The calves were 9 \u00b1 2 days old when vaccinated (day 0). The calves were challenged by aerosolized BRSV on days 80 and 81 as a respiratory challenge. The study was terminated on day 88. Lung lesion scores (LLS) were significantly lower for calves vaccinated with trivalent MLV vaccine than those for calves that were sham-vaccinated. Serum neutralization (SN) antibody against BRSV in calves vaccinated with the trivalent MLV vaccine demonstrated an anamnestic response on day 88. After challenge, the calves sham-vaccinated with the placebo lost weight, while those vaccinated with the trivalent MLV vaccine gained weight. In this study, colostrum-derived antibodies did not interfere with the immune response or protection provided by one dose of the trivalent MLV vaccine.<\/jats:p>","DOI":"10.3390\/pathogens13060517","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T08:06:06Z","timestamp":1718784366000},"page":"517","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Detection of Vaccine Virus and Protection of a Modified Live, Intranasal, Trivalent Vaccine in Neonatal, Colostrum-Fed Calves with an Experimental Bovine Respiratory Syncytial Virus Challenge"],"prefix":"10.3390","volume":"13","author":[{"given":"Stephanie","family":"Perkins-Oines","sequence":"first","affiliation":[{"name":"Clinvet-South Dakota, 801 32nd Ave, Brookings, SD 57006, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirosh D.","family":"Senevirathne","sequence":"additional","affiliation":[{"name":"Clinvet-South Dakota, 801 32nd Ave, Brookings, SD 57006, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta M.","family":"Krafsur","sequence":"additional","affiliation":[{"name":"Clinvet-South Dakota, 801 32nd Ave, Brookings, SD 57006, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6747-257X","authenticated-orcid":false,"given":"Karim","family":"Abdelsalam","sequence":"additional","affiliation":[{"name":"Clinvet-South Dakota, 801 32nd Ave, Brookings, SD 57006, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Renter","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine\/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent","family":"Meyer","sequence":"additional","affiliation":[{"name":"Beef Technical Services, Merck Animal Health, DeSoto, KS 66018, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6000-4095","authenticated-orcid":false,"given":"Christopher C. L.","family":"Chase","sequence":"additional","affiliation":[{"name":"Clinvet-South Dakota, 801 32nd Ave, Brookings, SD 57006, USA"},{"name":"Department of Veterinary and Biomedical Sciences, College of Agriculture, Food and Environmental Sciences, South Dakota State University, Brookings, SD 57007, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1017\/S1466252320000080","article-title":"The National Animal Health Monitoring System\u2019s Perspective on Respiratory Disease in Dairy Cattle","volume":"21","author":"Short","year":"2020","journal-title":"Anim. Health Res. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1017\/S1466252320000079","article-title":"Impact of Bovine Respiratory Disease in U.S. Beef Cattle","volume":"21","author":"White","year":"2020","journal-title":"Anim. Health Res. 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