{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:25:53Z","timestamp":1769084753224,"version":"3.49.0"},"reference-count":55,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brain Research Africa Initiative (BRAIN)","award":["U19AG074865"],"award-info":[{"award-number":["U19AG074865"]}]},{"name":"Brain Research Africa Initiative (BRAIN)","award":["OS000001018"],"award-info":[{"award-number":["OS000001018"]}]},{"name":"Brain Research Africa Initiative (BRAIN)","award":["1296723N"],"award-info":[{"award-number":["1296723N"]}]},{"name":"the National Institutes of Health, NIH (Recruitment and Retention for Alzheimer\u2019s Disease Diversity Cohorts in the Alzheimer\u2019s Disease Sequencing, READD-ADSP Project, Cameroon site)","award":["U19AG074865"],"award-info":[{"award-number":["U19AG074865"]}]},{"name":"the National Institutes of Health, NIH (Recruitment and Retention for Alzheimer\u2019s Disease Diversity Cohorts in the Alzheimer\u2019s Disease Sequencing, READD-ADSP Project, Cameroon site)","award":["OS000001018"],"award-info":[{"award-number":["OS000001018"]}]},{"name":"the National Institutes of Health, NIH (Recruitment and Retention for Alzheimer\u2019s Disease Diversity Cohorts in the Alzheimer\u2019s Disease Sequencing, READD-ADSP Project, Cameroon site)","award":["1296723N"],"award-info":[{"award-number":["1296723N"]}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation\u2013Flanders (FWO)","doi-asserted-by":"publisher","award":["U19AG074865"],"award-info":[{"award-number":["U19AG074865"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation\u2013Flanders (FWO)","doi-asserted-by":"publisher","award":["OS000001018"],"award-info":[{"award-number":["OS000001018"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation\u2013Flanders (FWO)","doi-asserted-by":"publisher","award":["1296723N"],"award-info":[{"award-number":["1296723N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Recent research suggests that infection with Onchocerca volvulus induces neurocognitive decline. This study sought to compare the cognitive outcomes of elderly persons based on onchocerciasis infection status and report the overall prevalence of dementia in the rural Ntui Health District in Cameroon. A community-based approach was used to recruit 103 participants aged \u226560 years. Dementia screening was done using the Community Screening Interview for Dementia (CSID) tool with a cut-off value of \u226429.5. O. volvulus infection was determined via microscopic examination of skin snips and serological testing of Ov16 antibodies using rapid diagnostic tests. Overall, the prevalence of dementia was 10.7%. Among the tested individuals, 17.9% (15\/84) and 62.1% (41\/66) were positive for O. volvulus and Ov16 antibodies, respectively. A multivariable linear regression model of CSID scores found a significant positive association with education level (8.654; 95% CI: 2.0870 to 15.222). However, having a positive skin snip for O. volvulus (\u22123.399; 95% CI: \u22126.805 to 0.007) and inhaling tobacco (\u22125.441; 95% CI: \u22129.137 to \u22121.744) tended to lower the CSID scores. Ongoing onchocerciasis transmission in the Ntui Health District may constitute a risk factor for dementia. Strengthening onchocerciasis elimination and adopting healthier lifestyles would contribute to dementia prevention among the elderly residing in endemic communities.<\/jats:p>","DOI":"10.3390\/pathogens13070568","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T11:30:02Z","timestamp":1720438202000},"page":"568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dementia Prevalence and Onchocerca volvulus Infection among Rural Elderly Persons in the Ntui Health District, Cameroon: A Population-Based Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5082-7960","authenticated-orcid":false,"given":"Wepnyu Yembe","family":"Njamnshi","sequence":"first","affiliation":[{"name":"Brain Research Africa Initiative (BRAIN), Yaound\u00e9 P.O. Box 25625, Cameroon"},{"name":"Neuroscience Lab, Faculty of Medicine and Biomedical Sciences, The University of Yaound\u00e9 I, Yaound\u00e9 P.O. Box 1364, Cameroon"},{"name":"Division of Health Operations Research, Ministry of Public Health, Yaound\u00e9 P.O. Box 1937, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3544-1239","authenticated-orcid":false,"given":"Joseph Nelson","family":"Siewe Fodjo","sequence":"additional","affiliation":[{"name":"Brain Research Africa Initiative (BRAIN), Yaound\u00e9 P.O. Box 25625, Cameroon"},{"name":"Global Health Institute, University of Antwerp, Doornstraat 331, 2610 Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8659-2824","authenticated-orcid":false,"given":"Kongnyu Gamnsi","family":"Njamnshi","sequence":"additional","affiliation":[{"name":"Brain Research Africa Initiative (BRAIN), Yaound\u00e9 P.O. Box 25625, Cameroon"},{"name":"Neuroscience Lab, Faculty of Medicine and Biomedical Sciences, The University of Yaound\u00e9 I, Yaound\u00e9 P.O. Box 1364, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Ngarka","sequence":"additional","affiliation":[{"name":"Brain Research Africa Initiative (BRAIN), Yaound\u00e9 P.O. Box 25625, Cameroon"},{"name":"Neuroscience Lab, Faculty of Medicine and Biomedical Sciences, The University of Yaound\u00e9 I, Yaound\u00e9 P.O. Box 1364, Cameroon"},{"name":"Department of Neurology, Central Hospital Yaound\u00e9, Yaound\u00e9 P.O. Box 25625, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel K.","family":"Mengnjo","sequence":"additional","affiliation":[{"name":"Brain Research Africa Initiative (BRAIN), Yaound\u00e9 P.O. Box 25625, Cameroon"},{"name":"Neuroscience Lab, Faculty of Medicine and Biomedical Sciences, The University of Yaound\u00e9 I, Yaound\u00e9 P.O. Box 1364, Cameroon"},{"name":"Department of Neurology, Central Hospital Yaound\u00e9, Yaound\u00e9 P.O. Box 25625, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard N.","family":"Nfor","sequence":"additional","affiliation":[{"name":"Brain Research Africa Initiative (BRAIN), Yaound\u00e9 P.O. Box 25625, Cameroon"},{"name":"Neuroscience Lab, Faculty of Medicine and Biomedical Sciences, The University of Yaound\u00e9 I, Yaound\u00e9 P.O. Box 1364, Cameroon"},{"name":"Department of Neurology, Central Hospital Yaound\u00e9, Yaound\u00e9 P.O. Box 25625, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine A. F.","family":"Tsasse","sequence":"additional","affiliation":[{"name":"Higher Institute for Scientific and Medical Research, Yaound\u00e9 P.O. Box 5797, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius N. Taryunyu","family":"Njamnshi","sequence":"additional","affiliation":[{"name":"Brain Research Africa Initiative (BRAIN), Yaound\u00e9 P.O. Box 25625, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys","family":"Maestre","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5777-2608","authenticated-orcid":false,"given":"Jose E.","family":"Cavazos","sequence":"additional","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer\u2019s & Neurodegenerative Diseases, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA"},{"name":"Department of Neurology, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer\u2019s & Neurodegenerative Diseases, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA"},{"name":"Department of Neurology, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA"},{"name":"Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent S.","family":"Etoundi Ngoa","sequence":"additional","affiliation":[{"name":"Neuroscience Lab, Faculty of Medicine and Biomedical Sciences, The University of Yaound\u00e9 I, Yaound\u00e9 P.O. Box 1364, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Th\u00e9r\u00e8se","family":"Obama Abena Ondoa","sequence":"additional","affiliation":[{"name":"Brain Research Africa Initiative (BRAIN), Yaound\u00e9 P.O. Box 25625, Cameroon"},{"name":"Neuroscience Lab, Faculty of Medicine and Biomedical Sciences, The University of Yaound\u00e9 I, Yaound\u00e9 P.O. Box 1364, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-1553","authenticated-orcid":false,"given":"Bernard","family":"Fongang","sequence":"additional","affiliation":[{"name":"Brain Research Africa Initiative (BRAIN), Yaound\u00e9 P.O. Box 25625, Cameroon"},{"name":"Glenn Biggs Institute for Alzheimer\u2019s & Neurodegenerative Diseases, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA"},{"name":"Department of Population Health Sciences, University of Texas Health Science Center, San Antonio, TX 77030, USA"},{"name":"Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-C\u00e9cile","family":"Zoung-Kanyi Bissek","sequence":"additional","affiliation":[{"name":"Brain Research Africa Initiative (BRAIN), Yaound\u00e9 P.O. Box 25625, Cameroon"},{"name":"Neuroscience Lab, Faculty of Medicine and Biomedical Sciences, The University of Yaound\u00e9 I, Yaound\u00e9 P.O. Box 1364, Cameroon"},{"name":"Division of Health Operations Research, Ministry of Public Health, Yaound\u00e9 P.O. Box 1937, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-1511","authenticated-orcid":false,"given":"Alfred K.","family":"Njamnshi","sequence":"additional","affiliation":[{"name":"Brain Research Africa Initiative (BRAIN), Yaound\u00e9 P.O. Box 25625, Cameroon"},{"name":"Neuroscience Lab, Faculty of Medicine and Biomedical Sciences, The University of Yaound\u00e9 I, Yaound\u00e9 P.O. Box 1364, Cameroon"},{"name":"Department of Neurology, Central Hospital Yaound\u00e9, Yaound\u00e9 P.O. Box 25625, Cameroon"},{"name":"Brain Research Africa Initiative (BRAIN), 1226 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,6]]},"reference":[{"key":"ref_1","unstructured":"World Bank (2023, April 15). World Bank Open Data. Available online: https:\/\/data.worldbank.org\/country\/ZG."},{"key":"ref_2","unstructured":"(2023, January 25). Ageing and Health. 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