{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:53:02Z","timestamp":1788691982289,"version":"build-2803163510"},"reference-count":56,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"US NIH","award":["R01AR081125"],"award-info":[{"award-number":["R01AR081125"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Identifying spatial clusters of rabies in animals aids policymakers in allocating resources for rabies prevention and control. This study aimed to investigate spatial patterns and hotspots of rabies in different animal species at the county level in New Jersey. Data on animal rabies cases from January 1989 to December 2023 were obtained from the New Jersey Department of Health and aggregated by county. Global Moran\u2019s index (I) statistics were computed for each species to detect global spatial clustering (GeoDa version 1.22). Local Moran\u2019s indicators of spatial association (LISA) were computed to identify local clusters of rabies. The results from the LISA analysis were mapped using ArcGIS Pro to pinpoint cluster locations. A total of 9637 rabies cases were analyzed among raccoons (n = 6308), skunks (n = 1225), bats (n = 1072), cats (n = 597), foxes (n = 225), and groundhogs (n = 210). A global Moran\u2019s test indicated significant global spatial clustering in raccoons (I = 0.32, p = 0.012), foxes (I = 0.29, p = 0.011), and groundhogs (I = 0.37, p = 0.005). The LISA results revealed significant spatial clustering of rabies in raccoons and foxes in southeastern New Jersey and in groundhogs in northern New Jersey. These findings could guide the development of targeted oral rabies vaccination programs in high-risk New Jersey counties, reducing rabies exposure among domestic animals and humans.<\/jats:p>","DOI":"10.3390\/pathogens13090742","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T07:45:47Z","timestamp":1725003947000},"page":"742","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Spatial Clustering of Rabies by Animal Species in New Jersey, United States, from 1989 to 2023"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-5676","authenticated-orcid":false,"given":"Shamim","family":"Sarkar","sequence":"first","affiliation":[{"name":"Program in Public Health, Department of Family, Population, and Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6408-8596","authenticated-orcid":false,"given":"Jaymie R.","family":"Meliker","sequence":"additional","affiliation":[{"name":"Program in Public Health, Department of Family, Population, and Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"ref_1","unstructured":"CDC (2024, May 10). Rabies in the United States: Protecting Public Health, Available online: https:\/\/www.cdc.gov\/rabies\/php\/protecting-public-health\/index.html#:~:text=Testing%3A%20More%20than%20130%20labs%20test%20nearly%20100%2C000,year%2C%20over%204%2C000%20animals%20test%20positive%20for%20rabies."},{"key":"ref_2","unstructured":"CDC (2024, April 20). About Rabies, Available online: https:\/\/www.cdc.gov\/rabies\/about\/index.html."},{"key":"ref_3","unstructured":"CDC (2024, May 10). Clinical Overview of Rabies, Available online: https:\/\/www.cdc.gov\/rabies\/hcp\/clinical-overview\/index.html."},{"key":"ref_4","unstructured":"NJDOH (2024, April 02). Rabies Background and Technical Information, Available online: https:\/\/www.nj.gov\/health\/cd\/documents\/topics\/rabies\/rabies_background.pdf."},{"key":"ref_5","first-page":"1","article-title":"Rabies surveillance in the United States during 2022","volume":"1","author":"Ma","year":"2024","journal-title":"J. Am. Veter. Med. Assoc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.2460\/javma.1992.201.12.1873","article-title":"Benefits and costs of using an orally absorbed vaccine to control rabies in raccoons","volume":"201","author":"Uhaa","year":"1992","journal-title":"J. Am. Veter. Med. Assoc."},{"key":"ref_7","unstructured":"Reilly, S.J. (2014). Distribution of Wildlife Rabies in Central Appalachia and Analysis of Factors Influencing Human Exposure. [Master\u2019s Thesis, University of Kentucky College of Public Health]."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1089\/vbz.2016.2061","article-title":"Geographical Clusters and Predictors of Rabies in Three Southeastern States","volume":"17","author":"Reilly","year":"2017","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"869","DOI":"10.7589\/0090-3558-39.4.869","article-title":"Environmental and Human Demographic Features Associated with Epizootic Raccoon Rabies in Maryland, Pennsylvania, and Virginia","volume":"39","author":"Jones","year":"2003","journal-title":"J. Wildl. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1139\/z98-042","article-title":"Population density, survival, and rabies in raccoons in an urban national park","volume":"76","author":"Riley","year":"1998","journal-title":"Can. J. Zool."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1476-072X-6-14","article-title":"Spatial and temporal patterns of enzootic raccoon rabies adjusted for multiple covariates","volume":"6","author":"Recuenco","year":"2007","journal-title":"Int. J. Health Geogr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.7589\/0090-3558-26.2.170","article-title":"Land use associations and changes in population indices of urban raccoons during a rabies epizootic","volume":"26","author":"Anthony","year":"1990","journal-title":"J. Wildl. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1089\/153036602321131878","article-title":"Spatiotemporal Analysis of Epizootic Raccoon Rabies Propagation in Connecticut, 1991\u20131995","volume":"2","author":"Lucey","year":"2002","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_14","first-page":"89","article-title":"Spatiotemporal Analysis and Predictive Modeling of Rabies in Tennessee","volume":"10","author":"Hunt","year":"2018","journal-title":"J. Geogr. Inf. Syst."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1198\/108571108X383483","article-title":"Mountains, valleys, and rivers: The transmission of raccoon rabies over a heterogeneous landscape","volume":"13","author":"Wheeler","year":"2008","journal-title":"J. Agric. Biol. Environ. Stat."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3201\/eid0909.020608","article-title":"Skunk and Raccoon Rabies in the Eastern United States: Temporal and Spatial Analysis","volume":"9","author":"Guerra","year":"2003","journal-title":"Emerg. Infect. Dis."},{"key":"ref_17","unstructured":"Lawson, A.B. (2013). Statistical Methods in Spatial Epidemiology, John Wiley & Sons."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.7589\/JWD-D-23-00078","article-title":"A global perspective on oral vaccination of wildlife against rabies","volume":"60","author":"Rupprecht","year":"2024","journal-title":"J. Wildl. Dis."},{"key":"ref_19","unstructured":"Willsey, A., Laniewicz, B.R., Eidson, M., Trimarchi, C.V., Rudd, R., and Safford, M. (2001, January 12\u201316). Oral rabies vaccination of wildlife in the eastern Adirondack region of New York State. Proceedings of the Conference Program and Abstracts of the 12th Annual Rabies in the Americas, Peterborough, ON, Canada."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2460\/javma.2005.227.785","article-title":"Evaluation of oral rabies vaccination programs for control of rabies epizootics in coyotes and gray foxes: 1995\u20132003","volume":"227","author":"Sidwa","year":"2005","journal-title":"J. Am. Veter. Med. Assoc."},{"key":"ref_21","unstructured":"USDA (2024, August 25). Oral Rabies Vaccination, Available online: https:\/\/www.aphis.usda.gov\/national-wildlife-programs\/rabies\/vaccine."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"National Association of State Public Health Veterinarians, Compendium of Animal Rabies Prevention and Control Committee, Brown, C.M., Slavinski, S., Ettestad, P., Sidwa, T.J., Sorhage, F.E., and Prevention, C.O.A.R. (2016). Compendium of Animal Rabies Prevention and Control, 2016. J. Am. Veter. Med. Assoc., 248, 505\u2013517.","DOI":"10.2460\/javma.248.5.505"},{"key":"ref_23","unstructured":"USDA (2024, August 25). U.S. National Plan for Wildlife Rabies Management 2023\u20132027, Available online: https:\/\/www.aphis.usda.gov\/sites\/default\/files\/national-plan-wildlife-rabies-management-23-27.pdf."},{"key":"ref_24","unstructured":"USDA (2024, August 26). ORV Information by State, Available online: https:\/\/www.aphis.usda.gov\/national-wildlife-programs\/rabies\/orv-state."},{"key":"ref_25","unstructured":"MapsOfWorld (2024, March 14). New Jersey Counties. Available online: https:\/\/www.mapsofworld.com\/usa\/states\/new-jersey\/counties\/#:~:text=The%20US%20state%20of%20New%20Jersey%20is%20divided,cities%2C%20244%20townships%2C%2015%20towns%2C%20and%20four%20villages."},{"key":"ref_26","unstructured":"NJGOV (2024, March 15). State of New Jersey Profile, Available online: https:\/\/www.nj.gov\/njoem\/mitigation\/pdf\/2019\/mit2019_section4_State_Profile.pdf#:~:text=New%20Jersey%20is%20located%20in%20the%20Mid-Atlantic%20region,a%20population%20of%208%2C904%2C413%20%28ACS%205yr%20Estimates%2C%202015%29."},{"key":"ref_27","unstructured":"University, R. (2024, March 21). Population Density and New Jersey\u2019s Two Largest Racial\/Ethnic Minority Groups in 2020. Available online: https:\/\/policylab.rutgers.edu\/population-density-and-new-jerseys-two-largest-racial-ethnic-minority-groups-in-2020\/."},{"key":"ref_28","unstructured":"Worldpopulationreview (2024, March 15). New Jersey Population 2024. Available online: https:\/\/worldpopulationreview.com\/states\/new-jersey-population."},{"key":"ref_29","unstructured":"NJDOH (2024, May 20). Rabies Testing, Available online: https:\/\/www.nj.gov\/health\/phel\/public-health-lab-testing\/rabies\/."},{"key":"ref_30","unstructured":"NJDOH (2024, March 13). Animal Rabies Statistics 2024, Available online: https:\/\/www.nj.gov\/health\/cd\/statistics\/rabies-stats\/."},{"key":"ref_31","unstructured":"NJOGIS (2024, March 15). County Boundaries of New Jersey. Available online: https:\/\/njogis-newjersey.opendata.arcgis.com\/datasets\/newjersey::county-boundaries-of-nj\/explore\/."},{"key":"ref_32","first-page":"186","article-title":"The data model concept in statistical mapping","volume":"7","author":"Jenks","year":"1967","journal-title":"Int. Yearb. Cartogr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-publhealth-031811-124655","article-title":"A Review of Spatial Methods in Epidemiology, 2000\u20132010","volume":"33","author":"Auchincloss","year":"2012","journal-title":"Annu. Rev. Public Health"},{"key":"ref_34","unstructured":"Mitchell, A. (1999). The ESRI Guide to GIS Analysis: Geographic Patterns & Relationships, ESRI, Inc."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Anselin, L., Syabri, I., and Kho, Y. (2009). GeoDa: An introduction to spatial data analysis. Handbook of Applied Spatial Analysis: Software tools, Methods and Applications, Springer.","DOI":"10.1007\/978-3-642-03647-7_5"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/sim.4780140809","article-title":"Spatial disease clusters: Detection and inference","volume":"14","author":"Kulldorff","year":"1995","journal-title":"Stat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1538-4632.1995.tb00338.x","article-title":"Local indicators of spatial association\u2014LISA","volume":"27","author":"Anselin","year":"1995","journal-title":"Geogr. Anal."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/0022-4146.00224","article-title":"Testing for Local Spatial Autocorrelation in the Presence of Global Autocorrelation","volume":"41","author":"Ord","year":"2001","journal-title":"J. Reg. Sci."},{"key":"ref_39","first-page":"157","article-title":"Exploring spatial data with GeoDaTM: A workbook","volume":"1963","author":"Anselin","year":"2005","journal-title":"Cent. Spatially Integr. Soc. Sci."},{"key":"ref_40","unstructured":"Desktop, E.A. (2019). ArcGIS Pro, Environmental Systems Research Institute."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.prevetmed.2008.03.001","article-title":"Factors associated with endemic raccoon (Procyon lotor) rabies in terrestrial mammals in New York State, USA","volume":"86","author":"Recuenco","year":"2008","journal-title":"Prev. Veter. Med."},{"key":"ref_42","unstructured":"Recuenco, S.E. (2006). Use of Raccoon Rabies Spatial Patterns to Optimize Efficiency of Oral Rabies Vaccine Interventions. [Ph.D. Thesis, State University of New York at Albany]."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.prevetmed.2005.07.009","article-title":"Assessing the role of long-distance translocation and spatial heterogeneity in the raccoon rabies epidemic in Connecticut","volume":"71","author":"Smith","year":"2005","journal-title":"Prev. Veter. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2460\/javma.245.3.333","article-title":"Rabies in rodents and lagomorphs in the United States, 1995\u20132010","volume":"245","author":"Fitzpatrick","year":"2014","journal-title":"J. Am. Veter. Med. Assoc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/oxfordjournals.aje.a114674","article-title":"Descriptive epidemiology from an epizootic of raccoon rabies in the middle atlantic states, 1982\u20131983","volume":"126","author":"Jenkins","year":"1987","journal-title":"Am. J. Epidemiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.2460\/javma.1994.205.12.1695","article-title":"Rabies surveillance in the United States during 1993","volume":"205","author":"Krebs","year":"1994","journal-title":"J. Am. Veter. Med. Assoc."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1073\/pnas.042400799","article-title":"Predicting the spatial dynamics of rabies epidemics on heterogeneous landscapes","volume":"99","author":"Smith","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"752","DOI":"10.7589\/0090-3558-34.4.752","article-title":"Efficacy of an oral vaccinia-rabies glycoprotein recombinant vaccine in controlling epidemic raccoon rabies in New Jersey","volume":"34","author":"Roscoe","year":"1998","journal-title":"J. Wildl. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1089\/vbz.2009.0089","article-title":"Time Series Analysis of the Impact of Oral Vaccination on Raccoon Rabies in West Virginia, 1990\u20132007","volume":"10","author":"Ma","year":"2010","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.3201\/eid1508.081061","article-title":"Tactics and Economics of Wildlife Oral Rabies Vaccination, Canada and the United States","volume":"15","author":"Sterner","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Buzzelli, M. (2020). Modifiable areal unit problem. Int. Encycl. Hum. Geogr., 169\u2013173.","DOI":"10.1016\/B978-0-08-102295-5.10406-8"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Elmore, S.A., Chipman, R.B., Slate, D., Huyvaert, K.P., VerCauteren, K.C., and Gilbert, A.T. (2017). Management and modeling approaches for controlling raccoon rabies: The road to elimination. PLoS Neglected Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005249"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1017\/S003118201200090X","article-title":"Integrating the landscape epidemiology and genetics of RNA viruses: Rabies in domestic dogs as a model","volume":"139","author":"Brunker","year":"2012","journal-title":"Parasitology"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Elser, J.L., Bigler, L.L., Anderson, A.M., Maki, J.L., Lein, D.H., and Shwiff, S.A. (2016). The Economics of a Successful Raccoon Rabies Elimination Program on Long Island, New York. PLoS Neglected Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0005062"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.2460\/javma.23.02.0081","article-title":"Rabies surveillance in the United States during 2021","volume":"261","author":"Ma","year":"2023","journal-title":"J. Am. Veter. Med. Assoc."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Johnston, D.H., and Tinline, R.R. (2003). Rabies control in wildlife. Rabies, Elsevier.","DOI":"10.1016\/B978-012379077-4\/50016-X"}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/13\/9\/742\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:45:37Z","timestamp":1760111137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/13\/9\/742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":56,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["pathogens13090742"],"URL":"https:\/\/doi.org\/10.3390\/pathogens13090742","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]}}}