{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:33:53Z","timestamp":1770975233021,"version":"3.50.1"},"reference-count":96,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Minas Gerais Research Foundation (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais\u2014FAPEMIG)","doi-asserted-by":"publisher","award":["RED-00008-14"],"award-info":[{"award-number":["RED-00008-14"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>This study investigated the occurrence and dynamics of oral Staphylococcus species in patients with orofacial clefts undergoing surgical rehabilitation treatment. Patients (n = 59) were statistically stratified and analyzed (age, gender, types of orofacial clefts, surgical history, and types of previous surgical rehabilitation). Salivary samples were obtained between hospitalization and the return to the specialized medical center. Microbiological diagnosis was performed by classical methods, and MALDI-TOF MS. MRSA strains (SCCmec type II, III, and IV) were characterized by the Decision Tree method. A total of 33 (55.9%) patients showed oral staphylococcal colonization in one, two, or three sampling steps. A high prevalence has been reported for S. aureus (including HA-, MRSA and CA-MRSA), followed by S. saprophyticus, S. epidermidis, S. sciuri, S. haemolyticus, S. lentus, S. arlettae, and S. warneri. The dynamics of oral colonization throughout surgical treatment and medical follow-up may be influenced by (i) imbalances in staphylococcal maintenance, (ii) efficiency of surgical asepsis or break of the aseptic chain, (iii) staphylococcal neocolonization in newly rehabilitated anatomical oral sites, and (iv) total or partial maintenance of staphylococcal species. The highly frequent clinical periodicity in specialized medical and dental centers may contribute to the acquisition of MRSA in these patients.<\/jats:p>","DOI":"10.3390\/pathogens13090763","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T02:34:06Z","timestamp":1725503646000},"page":"763","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral Staphylococcus Species and MRSA Strains in Patients with Orofacial Clefts Undergoing Surgical Rehabilitation Diagnosed by MALDI-TOF MS"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1128-3427","authenticated-orcid":false,"given":"Mateus Cardoso","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (FOP\/UNICAMP), 901 Limeira Ave, Piracicaba 13414-903, SP, Brazil"},{"name":"Center for Nursing and Health, State University of Southwest Bahia (UESB), Jos\u00e9 Moreira Sobrinho Avenue, Jequi\u00e9 45205-490, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Fabiano Gomes","family":"Boriollo","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (FOP\/UNICAMP), 901 Limeira Ave, Piracicaba 13414-903, SP, Brazil"},{"name":"Department of Morphology and Pathology & Biotechnology Graduate Program (PPGBiotec), Center for Biological and Health Sciences (CCBS), Federal University of S\u00e3o Carlos (UFSCar), Km 235 Washington Lu\u00eds Road, S\u00e3o Carlos 13565-905, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica Cristina de","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Biology, Federal University of Lavras (UFLA), s\/n Edmir S\u00e1 Santos Rotary Interchange, Lavras 37203-202, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00edsla Andrielle da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (FOP\/UNICAMP), 901 Limeira Ave, Piracicaba 13414-903, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1370-4544","authenticated-orcid":false,"given":"Jeferson J\u00fanior da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (FOP\/UNICAMP), 901 Limeira Ave, Piracicaba 13414-903, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-9331","authenticated-orcid":false,"given":"Karina Teixeira","family":"Magalh\u00e3es-Guedes","sequence":"additional","affiliation":[{"name":"Department of Bromatological Analysis, Pharmacy Faculty, Federal University of Bahia (UFBA), 147 Bar\u00e3o de Jeremoabo Street, Salvador 40170-115, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1015-1761","authenticated-orcid":false,"given":"Carlos Tadeu dos Santos","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Exact Sciences, College of Agriculture, University of S\u00e3o Paulo (ESALQ\/USP), 11 P\u00e1dua Dias Ave, Piracicaba 13418-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner Lu\u00eds de Carvalho","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (FOP\/UNICAMP), 901 Limeira Ave, Piracicaba 13414-903, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Francisco","family":"H\u00f6fling","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (FOP\/UNICAMP), 901 Limeira Ave, Piracicaba 13414-903, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7151-5085","authenticated-orcid":false,"given":"Cristina Paiva de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Morphology and Pathology & Biotechnology Graduate Program (PPGBiotec), Center for Biological and Health Sciences (CCBS), Federal University of S\u00e3o Carlos (UFSCar), Km 235 Washington Lu\u00eds Road, S\u00e3o Carlos 13565-905, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.arcped.2018.08.001","article-title":"SPINA classification of cleft lip and palate: A suggestion for a complement","volume":"25","author":"Rodrigues","year":"2018","journal-title":"Arch. 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