{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T18:43:48Z","timestamp":1772045028262,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>From 2011 to 2012, Northern Vietnam suffered its first large-scale hand, foot, and mouth disease (HFMD) epidemic. Two sets of official guidelines were issued during the outbreak to handle the HFMD crisis. The city of Hai Phong was used as a model to analyze the impact of the released guidelines. A total of 9621 HFMD cases were reported in Hai Phong city from April 2011 to December 2012. Three distinct waves of HFMD occurred. Enterovirus A71 and Coxsackievirus A16 were successively associated with the epidemics. Two periods, before and after the guidelines\u2019 release, could be distinguished and characterized by different patient patterns. The time to admission and severity changed notably. Guideline publications help the health system refocus on the 0.5\u20133 years age group with the highest incidence of the disease. The three waves showed different special distribution, but the main routes of infection were rivers and local secondary roads, most likely through local trade and occupational movements of people.<\/jats:p>","DOI":"10.3390\/pathogens13090777","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T10:42:22Z","timestamp":1725878542000},"page":"777","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Monitoring the Influence of Hand, Foot, and Mouth Disease: New Guidelines on Patient Care during the 2011\u20132012 Multiwaves and Multivariant Outbreak in Hai Phong City, Vietnam"],"prefix":"10.3390","volume":"13","author":[{"given":"Nghia Ngu","family":"Duy","sequence":"first","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, 1 Yersin Street, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Thi Thanh","family":"Huong","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, 1 Yersin Street, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-7343","authenticated-orcid":false,"given":"Patrice","family":"Ravel","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Canc\u00e9rologie de Montpellier (U1194), IRCM, Universit\u00e9 de Montpellier, Campus Val d\u2019Aurelle, CEDEX 5, 34298 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Thi Song","family":"Huong","sequence":"additional","affiliation":[{"name":"Hai Phong Preventive Medicine Center, Hai Phong City 180000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7294-1975","authenticated-orcid":false,"given":"Ankit","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Canc\u00e9rologie de Montpellier (U1194), IRCM, Universit\u00e9 de Montpellier, Campus Val d\u2019Aurelle, CEDEX 5, 34298 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilhem","family":"Kister","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Montpellier, 15 av Charles Flahault, BP14491, CEDEX 5, 34093 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Gavotte","sequence":"additional","affiliation":[{"name":"Espace-DEV, Universit\u00e9 de Montpellier, 500 Rue Jean Fran\u00e7ois Breton, 34090 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian A.","family":"Devaux","sequence":"additional","affiliation":[{"name":"IHU M\u00e9diterran\u00e9e-Infection, 19-21 Bd Jean Moulin, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6168-4555","authenticated-orcid":false,"given":"Vu Dinh","family":"Thiem","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, 1 Yersin Street, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Hien","family":"Thanh","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, 1 Yersin Street, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Nhu","family":"Duong","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, 1 Yersin Street, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Tran","family":"Hien","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, 1 Yersin Street, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-1162","authenticated-orcid":false,"given":"Emmanuel","family":"Cornillot","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Canc\u00e9rologie de Montpellier (U1194), IRCM, Universit\u00e9 de Montpellier, Campus Val d\u2019Aurelle, CEDEX 5, 34298 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8926-3119","authenticated-orcid":false,"given":"Roger","family":"Frutos","sequence":"additional","affiliation":[{"name":"CIRAD, UMR 17, Intertryp, TA-A17\/G, Campus International de Baillarguet, CEDEX 5, 34398 Montpellier, France"},{"name":"Faculty of Medicine-Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"ref_1","unstructured":"WHO (2011). 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