{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:44:34Z","timestamp":1781199874209,"version":"3.54.1"},"reference-count":17,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Shiga toxin-producing Escherichia coli (STEC) can cause severe clinical disease in humans, particularly in young children. Recent advances have led to greater availability of sequencing technologies. We sought to use whole genome sequencing data to identify the presence or absence of known virulence factors in all clinical isolates submitted to our laboratory from Southern Alberta dated 2020\u20132022 and correlate these virulence factors with clinical outcomes obtained through chart review. Overall, the majority of HUS and hospitalizations were seen in patients with O157:H7 serotypes, and HUS cases were primarily in young children. The frequency of virulence factors differed between O157:H7 and non-O157 serotypes. Within the O157:H7 cases, certain virulence factors, including espP, espX1, and katP, were more frequent in HUS cases. The number of samples was too low to determine statistical significance.<\/jats:p>","DOI":"10.3390\/pathogens13100822","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T10:41:47Z","timestamp":1727174507000},"page":"822","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Outcomes and Virulence Factors of Shiga Toxin-Producing Escherichia coli (STEC) from Southern Alberta, Canada, from 2020 to 2022"],"prefix":"10.3390","volume":"13","author":[{"given":"Heather","family":"Glassman","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Suttorp","sequence":"additional","affiliation":[{"name":"Medical Officer of Health, Alberta Health Services, Lethbridge, AB T1J 4E1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theron","family":"White","sequence":"additional","affiliation":[{"name":"Environmental Public Health, South Zone, Alberta Health Services, Taber, AB T1G 1N9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Ziebell","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory at Guelph, Public Health Agency of Canada, Guelph, ON N1G 3W4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Kearney","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3C 4W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyrylo","family":"Bessonov","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory at Guelph, Public Health Agency of Canada, Guelph, ON N1G 3W4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Li","sequence":"additional","affiliation":[{"name":"Alberta Precision Laboratories-Public Health Laboratory, Edmonton, AB T6G 2J2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0851-9803","authenticated-orcid":false,"given":"Linda","family":"Chui","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada"},{"name":"Alberta Precision Laboratories-Public Health Laboratory, Edmonton, AB T6G 2J2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.medmal.2017.09.012","article-title":"Hemolytic uremic syndrome due to Shiga toxin-producing Escherichia coli infection","volume":"48","author":"Bruyand","year":"2018","journal-title":"Med. 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