{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T11:21:55Z","timestamp":1770549715376,"version":"3.49.0"},"reference-count":135,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u2018VICTOR BABES\u2019 UNIVERSITY OF MEDICINE AND PHARMACY TIMISOARA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Purpose: Cytomegalovirus (CMV) retinitis is a sight-threatening condition predominantly affecting immunocompromised individuals, such as those with Human Immunodeficiency Virus (HIV)\/Acquired Immunodeficiency Syndrome (AIDS). We aimed to present an observational case report on CMV retinitis following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and to review the literature on the molecular and cellular changes in CMV and SARS-CoV-2 infections and how they may influence each other. Case Description: A 32-year-old man with a history of AIDS presented with decreased vision and ocular pain exacerbated by movement, beginning a day prior. Ocular examination revealed anterior uveitis, corneal endothelial edema, and retinal necrosis in the left eye. CMV retinitis was diagnosed based on positive serologic testing and a low cluster of differentiation 4 (CD4) count, with concurrent SARS-CoV-2 infection detected. Treatment included valganciclovir and topical agents, with a focus on managing CMV complications. This case highlights the potential role of SARS-CoV-2 in reactivating dormant CMV in severely immunocompromised individuals. We also discuss the implications of this interaction for immunocompromised patients, emphasizing the need for vigilant monitoring and personalized treatment strategies. Conclusions: Our case suggests that SARS-CoV-2 may trigger reactivation of CMV infection, leading to bilateral involvement in patients with low CD4 lymphocyte counts, which can result in severe visual impairment. The review discusses the molecular and cellular interactions between CMV and SARS-CoV-2, as well as risk factors, pathophysiology, and diagnostic methods for CMV retinitis, providing recommendations based on the literature findings.<\/jats:p>","DOI":"10.3390\/pathogens13110938","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T06:29:57Z","timestamp":1730183397000},"page":"938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["CMV Retinitis in the Context of SARS-CoV-2 Infection: A Case Study and Comprehensive Review of Viral Interactions"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-3340","authenticated-orcid":false,"given":"Emil Robert","family":"Stoicescu","sequence":"first","affiliation":[{"name":"Radiology and Medical Imaging University Clinic, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Research Center for Medical Communication, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Field of Applied Engineering Sciences, Specialization Statistical Methods and Techniques in Health and Clinical Research, Faculty of Mechanics, \u2018Politehnica\u2019 University Timisoara, Mihai Viteazul Boulevard No. 1, 300222 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-5438","authenticated-orcid":false,"given":"Laura Andreea","family":"Ghenciu","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Center for Translational Research and Systems Medicine, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-712X","authenticated-orcid":false,"given":"Roxana","family":"Iacob","sequence":"additional","affiliation":[{"name":"Research Center for Medical Communication, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Field of Applied Engineering Sciences, Specialization Statistical Methods and Techniques in Health and Clinical Research, Faculty of Mechanics, \u2018Politehnica\u2019 University Timisoara, Mihai Viteazul Boulevard No. 1, 300222 Timisoara, Romania"},{"name":"Department of Anatomy and Embriology, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adina Iuliana","family":"Ardelean","sequence":"additional","affiliation":[{"name":"Discipline of Ophtalmology, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ecaterina","family":"D\u0103escu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embriology, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidiu Alin","family":"Ha\u021began","sequence":"additional","affiliation":[{"name":"Discipline of Anatomy and Embriology, Medicine Faculty, \u201cVasile Goldis\u201d Western University of Arad, Revolution Boulevard 94, 310025 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Manolescu","sequence":"additional","affiliation":[{"name":"Radiology and Medical Imaging University Clinic, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Center for Research and Innovation in Precision Medicine of Respiratory Diseases (CRIPMRD), \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-3185","authenticated-orcid":false,"given":"Emanuela","family":"Tudorache","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Precision Medicine of Respiratory Diseases (CRIPMRD), \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casiana","family":"Boru","sequence":"additional","affiliation":[{"name":"Discipline of Anatomy and Embriology, Medicine Faculty, \u201cVasile Goldis\u201d Western University of Arad, Revolution Boulevard 94, 310025 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirabela","family":"Dima","sequence":"additional","affiliation":[{"name":"Department of Neonatology, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.21037\/aes-21-18","article-title":"Cytomegalovirus retinitis in the highly active anti-retroviral therapy era","volume":"7","author":"Ude","year":"2022","journal-title":"Ann. 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